Results 101 to 110 of about 7,283,036 (268)

In silico prediction of novel effective combinational treatment of chronic pain in individual patients: A joint white paper of the H2020 QSPainRelief consortium

British Journal of Pharmacology, EarlyView.
Abstract Opioids are prescribed widely for chronic pain despite well‐recognised risks and variable long‐term benefit, reflecting the lack of effective alternatives for many patients. Combination therapies offer a promising strategy to enhance efficacy whilst reducing side effects.
André Mouraux, Solenn Gousset, Beltrán Alvarez, Monica Baiula, Wouter Bakker, Andrea Bedini, Monir Bertayli, Divakar Budda, Robert Carr, Elisabetta Cuna, Óscar Díaz, Nina Donner, Jesús Giraldo, Geert‐Jan Groeneveld, Berfin Gülave, David Guydan, Hemme Hijma, Rafael Maldonado, Pedro Renault, Carlos Rinaudo, Jeroen Elaissaiss‐Schaap, Athan Spiros, Sara Stoeber, Petri Takkala, Daan van Valkengoed, Coen van Hasselt, Elizabeth (Liesbeth) C.M. de Lange   +26 more
wiley   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

Surgical management of congenital extrahepatic portosystemic shunt in a pony foal

Equine Veterinary Education, EarlyView.
Summary A five‐month‐old Welsh pony filly was admitted to the Veterinary Teaching Hospital of the University of Helsinki due to neurological signs. Clinicopathological findings showed elevated ammonium and bile acid levels. Computed tomography revealed an aberrant vessel originating from an enlarged splenic vein, leading to the right azygos vein ...
N. Hakonen, K. Niinistö, M. Laitinen, S. Mölsä, H. Tapio   +4 more
wiley   +1 more source

TREATMENT OF HEROIN ADDICTION WITH METHADONE IN THE CENTREFOR PREVENTION AND TREATMENT OF ADDICTION OF ILLICIT DRUGSLOGATEC

Zdravniški Vestnik, 2008
BACKGROUND The attitude of lay and medical public towards methadone treatment still stays charged byprejudices because of the lack of knowledge and misunderstanding of such treatment.
Jasna Čuk Rupnik
doaj  

ABCB1 and cytochrome P450 genotypes and phenotypes: influence on methadone plasma levels and response to treatment

, 2006
BACKGROUND AND OBJECTIVE: The in vivo implication of various cytochrome P450 (CYP) isoforms and of P-glycoprotein on methadone kinetics is unclear.
Hämmig, Robert, Déglon, Jean-Jacques, Monnat, Martine, Hämmig, R., Croquette-Krokar, Marina, Monnat, M., Croquette-Krokar, M., Déglon, J.J., Eap, C.B., Crettol, Séverine, Gothuey, Isabelle, Gothuey, I., Besson, J., Eap, Chin B, Crettol, S., Besson, Jacques, Eap CB, Besson J, Crettol S, Déglon JJ, Monnat M, Hämmig R, Gothuey I, Croquette-Krokar M   +23 more
core   +1 more source

Use of thoracic computed tomography in the diagnosis of a pulmonary myxoma in a horse

Equine Veterinary Education, EarlyView.
Summary This case describes the first reported antemortem computed tomographic (CT) examination of the thorax in an adult horse. A 13‐year‐old Australian Stock Horse gelding presented for a severe cough, epistaxis and haemoptysis after a 1‐year history of suspected equine asthma.
E. Hodgson, F. Pauwels, L. Woolford, O. Jones, L. Silvera, D. Feary   +5 more
wiley   +1 more source

‘A Noose Around the Neck’: Financial Penalties, Extended Enforcement, and Barriers to Rehabilitation

The Howard Journal of Crime and Justice, EarlyView.
ABSTRACT Fines are commonly assumed to be non‐disruptive sanctions, creating no barriers to rehabilitation or reintegration. In this paper, which draws on interviews with nine community justice practitioners in Scotland, I show how fines enforcement is a neglected aspect of contemporary punishment, one which often obstructs prospects for rehabilitation
Amy Cullen
wiley   +1 more source

Matrix Model for Methamphetamine Dependence Among Iranian Female Methadone Patients: The First Report From the Most Populated Persian Gulf Country

Iranian Rehabilitation Journal, 2017
Objectives: Methamphetamine (MA) dependence is a new health problem among Iranian female methadone patients. In recent years, the Matrix Model (a sixteen-week psychosocial treatment) has been provided for treating MA dependence.
Omid Massah, Mohammad Effatpanah, Sara Shishehgar   +2 more
doaj  

Methadone treatment: Methadone treatment is not the only option [PDF]

BMJ, 1996
openaire   +1 more source

Trends in Dispensing of Opioids and Benzodiazepines Among Older Adults Admitted for an Acute Hip Fracture Between 2008 and 2024 in Ontario, Canada

Journal of the American Geriatrics Society, EarlyView.
ABSTRACT Introduction Opioids and benzodiazepines (BZDs) are commonly prescribed for managing pain, anxiety, and sleep‐related problems following a hip fracture. Both opioids and BZDs carry risks of persistent dependence, falls, and mortality with long‐term use. Despite these risks, Canada lacks standardized prescribing guidelines for older adults with
Anum Ali, Mina Tadrous, Chizaram Eje, Laleh Rashidian, Arrani Senthinathan, Cherry Chu, Kerry Kuluski, Sara J. T. Guilcher   +7 more
wiley   +1 more source