Results 191 to 200 of about 94,112 (278)

3,4‐Methylenedioxymethamphetamine (MDMA) does not induce robust psychomotor activation and 50‐kHz ultrasonic vocalisations in tryptophan hydroxylase 2 (Tph2)‐deficient rats lacking serotonin in the central nervous system

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 7, Page 1539-1556, April 2026.
Background and Purpose 3,4‐Methylenedioxymethamphetamine (MDMA), commonly known as ecstasy, is a psychostimulant with entactogenic properties and known to induce arousal and euphoria. As an amphetamine derivate, MDMA acts on the monoamine systems in the brain and stimulates release of dopamine (DA), noradrenaline (NA) and serotonin (5‐HT), yet their ...
Tianhua Wang   +2 more
wiley   +1 more source

Evaluation of preclinical antipsychotic models used to support first‐in‐human clinical trials

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 7, Page 1364-1389, April 2026.
Abstract Schizophrenia is regarded as a complex and heterogeneous psychiatric disorder, characterised by diverse symptoms and comorbidities, which complicate both clinical management and drug development. Current pharmacological treatment, primarily based on dopamine D2 receptor antagonism or partial agonism, which has not markedly progressed since the
Thi Viet Ha Nguyen   +2 more
wiley   +1 more source

Trends in Injecting Methamphetamine and Opioids Among People Who Inject Drugs in the US. [PDF]

open access: yesJAMA
D'Adamo A   +6 more
europepmc   +1 more source

Examining the Effectiveness of Typologies of Violence Used in Predicting and Responding to Workplace Violence Against Nurses: A Rapid Review

open access: yesInternational Journal of Nursing Practice, Volume 32, Issue 2, April 2026.
ABSTRACT Background The rate of violence against nurses far exceeds what should be reasonably accepted and suggests this is an issue that requires targeted intervention. Typologies have been used to predict violence, but there is a gap in the literature on antecedent and precipitating factors that lead to violence against nurses.
Joel Robert McGregor   +3 more
wiley   +1 more source

Game Changers in the Treatment of and Engagement With Persons Living With Mental Health and Substance Use Disorders: The Role of the Nurse

open access: yesInternational Journal of Mental Health Nursing, Volume 35, Issue 2, April 2026.
ABSTRACT The game changers in mental health and substance use disorder treatment have been shaped by historical sea changes marked by transformative advancements that have significantly enhanced patient care. Breakthroughs in psychotherapy, psychosurgery and psychopharmacology have each contributed to reshaping clinical practices, especially the ...
Arlene Kent‐Wilkinson   +2 more
wiley   +1 more source

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