Results 71 to 80 of about 94,112 (278)

Bioactivation and Metabolism of Amino Acid MDMA Prodrugs in Zebrafish Embryos, Human Liver S9, Whole Blood, and Microdosed Human Urine

Drug Testing and Analysis, EarlyView.
Bioactivation and metabolism of MDMA prodrugs: MDMA‐Trp, MDMA‐Lys, MDMA‐Gly showed unique urine screening targets only for MDMA‐Trp, while biomarkers for MDMA‐Lys and MDMA‐Gly consisted of MDMA and known MDMA metabolites. Conversion of amino acid prodrugs to MDMA in pHLS9, zebrafish embryos, and humans. ABSTRACT 3,4‐Methylenedioxymethamphetamine (MDMA)
Simon K. Wellenberg, Lea Wagmann, Matthias D. Kroesen, Philip Schippers, Matthias Grill, Jennifer Herrmann, Markus R. Meyer   +6 more
wiley   +1 more source

Ameliorative Effects of Silymarin on Methamphetamine-Induced Neurobehavioral and Histopathological Alterations in Adolescent Wistar Rats [PDF]

Caspian Journal of Neurological Sciences
Background: One of the most significant public health concerns in our local communities is the high prevalence of methamphetamine use among teenagers.
Princewill Sopuluchukwu Udodi, Kelechi Blessed Ndubuisi, Uchenna Confidence Mofunanya, Promise Chukwuebuka Onuorah, Ukamaka Peace Odunwa, Sylvia Chinaecherem Ndinojuo, Damian Nnabuihe Ezejindu, Roseline Ebube Udodi   +7 more
doaj  

Low Dopamine D2/D3 Receptor Availability is Associated with Steep Discounting of Delayed Rewards in Methamphetamine Dependence. [PDF]

, 2015
BackgroundIndividuals with substance use disorders typically exhibit a predilection toward instant gratification with apparent disregard for the future consequences of their actions.
Ballard, Michael E, Dean, Andy C, Hsu, Eustace, Ishibashi, Kenji, London, Edythe D, Mandelkern, Mark A, Monterosso, John R, Robertson, Chelsea L   +7 more
core   +3 more sources

Understanding Substance Use and Suicide Risk Among LGBTQ+ College Students Post‐COVID‐19

Journal of Addictions &Offender Counseling, EarlyView.
ABSTRACT This study examines the reported frequency of substance use, levels of suicide risk, and their relationships among LGBTQ+ college students (N = 192) following the COVID‐19 pandemic. Participants most commonly reported alcohol and marijuana use, and least commonly reported unprescribed prescription opioid or heroin use.
Afroze N. Shaikh, Jordan B. Westcott, Brittney N. R. Irion, Jackie Yang, Illiana R. Navarra‐Bueno, Hannah Martinson, Noah Diaz   +6 more
wiley   +1 more source

Differences in patterns of attention deficit/hyperactivity disorder medication use in US children

JCPP Advances, EarlyView.
Abstract Background Understanding attention deficit/hyperactivity disorder (ADHD) medication patterns is crucial for optimizing treatment outcomes. There are limited data on racial, ethnic, gender and socioeconomic treatment differences across longitudinal national samples.
Jennie E. Ryan, Alexander Weigard, Sean Esteban McCabe, Timothy E. Wilens, Philip T. Veliz   +4 more
wiley   +1 more source

Antimicrobial Cyclic Peptidomimetics

Macromolecular Rapid Communications, EarlyView.
Singular macromolecular cationic, amphipathic cyclic peptidomimetics with poly(2‐oxazoline)s‐esque backbone structure that undergo self‐assembly in water to form uniform nanoparticles were developed. The cyclic peptidomimetics, which act on bacterial cell membranes, exhibit hydrophobic‐dependent antimicrobial activity and toxicity.
Hao Luo, Edgar H. H. Wong
wiley   +1 more source

Methamphetamine‐Associated Cardiomyopathy

Clinical Cardiology, 2013
AbstractMethamphetamine and related compounds are now the second most commonly used illicit substance worldwide, after cannabis. Reports of methamphetamine‐associated cardiomyopathy (MAC) are increasing, butMAChas not been well reviewed. This analysis ofMACwill provide an overview of the pharmacology of methamphetamine, historical perspective and ...
Sekon, Won, Robert A, Hong, Ralph V, Shohet, Todd B, Seto, Nisha I, Parikh   +4 more
openaire   +3 more sources

Community context and individual factors associated with arrests among young men in a South African township. [PDF]

, 2019
BackgroundIn high-income countries, individual- and community-level factors are associated with increased contact with the criminal justice system. However, little is known about how these factors contribute to the risk of arrest in South Africa, which ...
Bantjes, Jason, Christodoulou, Joan, Gordon, Sarah, Mayekiso, Andile, Rabie, Stephan, Rotheram-Borus, Mary Jane, Stewart, Jackie, Stokes, Lynissa R, Tomlinson, Mark   +8 more
core   +3 more sources

Modulation of Non‐Rhythmic Temporal Prediction by Subthalamic Nucleus Deep Brain Stimulation (STN‐DBS) in Parkinson's Disease

Movement Disorders, EarlyView.
Background Accurate temporal prediction, essential for adaptive motor behavior, relies on corticobasal ganglia circuits. In Parkinson's disease (PD), both motor and non‐motor functions are impaired. Deep brain stimulation (DBS) of the subthalamic nucleus (STN) effectively alleviates motor symptoms, but its effects on non‐motor domains, like temporal ...
Rebecca Burke, Marleen J. Schoenfeld, Christian K.E. Moll, Alessandro Gulberti, Monika Pötter‐Nerger, Andreas K. Engel   +5 more
wiley   +1 more source

A PLP‐SEC Investigation of Di(Ethylene Glycol) Methyl Ether Methacrylate Radical Polymerization Propagation Kinetics in Solution

Macromolecular Reaction Engineering, EarlyView.
The propagation rate coefficient of di(ethylene glycol) methyl ether methacrylate exhibits the same temperature dependency but is a factor of 12 higher in aqueous solution compared to bulk. Smaller increases are observed in ethanol and ethanol/water mixtures, with the value of the rate coefficient decreasing as the monomer concentration in solution is ...
Fatemeh Salarhosseini, Robin A. Hutchinson   +1 more
wiley   +1 more source