Results 101 to 110 of about 607,306 (389)

Plasma and Whole Blood Taurine Concentrations in Dogs May Not Be Sensitive Indicators of Taurine Deficiency When Dietary Sulfur Amino Acid Content Is Reduced

Frontiers in Veterinary Science, 2022
BackgroundTaurine status is impacted by dietary supply of methionine and cysteine (SAA) and possibly intestinal microbial activity, where plasma and whole blood taurine concentrations are currently used to evaluate taurine status.ObjectiveWe determined ...
Cristina L. Tôrres, Vincent C. Biourge, Robert C. Backus   +2 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

An infant with an extremely rare cobalamin disorder: Methionine synthase deficiency and importance of early diagnosis and treatment

The Turkish Journal of Pediatrics, 2019
Functional methionine synthase deficiency can be separated into two classes, cobalamin (Cbl) deficiency type E (CblE) and type G (CblG), which are the result of mutations that affect methionine synthase reductase or methionine synthase, respectively ...
Çiğdem Seher Kasapkara, Ebru Yılmaz-Keskin, Ferda Özbay-Hoşnut, Meltem Akçaboy, Emine Polat, Asburçe Olgaç, Pelin Zorlu   +6 more
doaj   +1 more source

Cysteine and Methionine Biosynthetic Enzymes Have Distinct Effects on Seed Nutritional Quality and on Molecular Phenotypes Associated With Accumulation of a Methionine-Rich Seed Storage Protein in Rice

Frontiers in Plant Science, 2020
Staple crops in human and livestock diets suffer from deficiencies in certain “essential” amino acids including methionine. With the goal of increasing methionine in rice seed, we generated a pair of “Push × Pull” double transgenic lines, each containing
Sarah J. Whitcomb, Apidet Rakpenthai, Franziska Brückner, Axel Fischer, Saroj Parmar, Alexander Erban, Joachim Kopka, Malcolm J. Hawkesford, Rainer Hoefgen   +8 more
doaj   +1 more source

The Formation of Methionine by a Methionine-Requiring Mutant of Neurospora crassa [PDF]

Journal of General Microbiology, 1959
SUMMARY: A methionine-requiring mutant of Neurospora crassa incorporated 35SO4 into methionine. This incorporation represents net synthesis of methionine by the mutant. It is quite likely that methionine synthesis proceeds by the normal pathway in the mutant.
B. S. Strauss, T. Minagawa
openaire   +3 more sources

The influence of ROS1 fusion partners and resistance mechanisms in ROS1‐TKI‐treated non‐small cell lung cancer patients

Molecular Oncology, EarlyView.
This real‐world study of ROS1+ NSCLC highlights fusion diversity, treatment outcomes with crizotinib and lorlatinib, and in vitro experiments with resistance mechanisms. G2032R drives strong resistance to ROS1‐targeted TKIs, especially lorlatinib. Fusion partner location does not affect overall survival to crizotinib or lorlatinib. Findings support the
Fenneke Zwierenga, Christa Dijkhuizen, Patrick Korthuis, Wim Timens, Harry Groen, Jeroen Hiltermann, Anke van den Berg, Lyndsay Drayer, Anthonie van der Wekken   +8 more
wiley   +1 more source

Intra-tumor L-methionine level highly correlates with tumor size in both pancreatic cancer and melanoma patient-derived orthotopic xenograft (PDOX) nude-mouse models. [PDF]

, 2018
An excessive requirement for methionine (MET) for growth, termed MET dependence, appears to be a general metabolic defect in cancer. We have previously shown that cancer-cell growth can be selectively arrested by MET restriction such as with recombinant ...
Chemielwski, Bartosz, Dry, Sarah M, Eckardt, Mark A, Eilber, Fritz C, Han, Qinghong, Hoffman, Robert M, Igarashi, Kentaro, Kawaguchi, Kei, Kiyuna, Tasuku, Li, Shukuan, Li, Yunfeng, Miyake, Kentaro, Miyake, Masuyo, Nelson, Scott D, Russell, Tara A, Singh, Arun S, Tan, Yuying, Unno, Michiaki   +17 more
core   +1 more source

Clustering of Aromatic Amino Acid Residues around Methionine in Proteins

Biomolecules, 2021
Short-range, non-covalent interactions between amino acid residues determine protein structures and contribute to protein functions in diverse ways. The interactions of the thioether of methionine with the aromatic rings of tyrosine, tryptophan, and/or ...
Curtis A. Gibbs, David S. Weber, Jeffrey J. Warren   +2 more
doaj   +1 more source

Oxidation Resistance of the Sulfur Amino Acids: Methionine and Cysteine

BioMed Research International, 2017
Sulfur amino acids are a kind of amino acids which contain sulfhydryl, and they play a crucial role in protein structure, metabolism, immunity, and oxidation.
Peng Bin, Ruilin Huang, Xihong Zhou
semanticscholar   +1 more source

Protein O‐glycosylation in the Bacteroidota phylum

FEBS Open Bio, EarlyView.
Species of the Bacteroidota phylum exhibit a unique O‐glycosylation system. It modifies noncytoplasmic proteins on a specific amino acid motif with a shared glycan core but a species‐specific outer glycan. A locus of multiple glycosyltransferases responsible for the synthesis of the outer glycan has been identified.
Lonneke Hoffmanns, Dennis Svedberg, André Mateus   +2 more
wiley   +1 more source