Results 61 to 70 of about 3,813 (143)

The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback

Cell Communication and Signaling, 2023
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various inflammatory endotypes. Recent epidemiological findings showed a T helper 2 (Th2)-skewed dominance in CRSwNP patients.
Lei Yu, Yi Wei, Tong Lu, Zhengqi Li, Shimin Lai, Yan Yan, Changhui Chen, Weiping Wen   +7 more
doaj   +1 more source

The new mechanism of cognitive decline induced by hypertension: High homocysteine-mediated aberrant DNA methylation

Frontiers in Cardiovascular Medicine, 2022
The prevalence and severity of hypertension-induced cognitive impairment increase with the prolonging of hypertension. The mechanisms of cognitive impairment induced by hypertension primarily include cerebral blood flow perfusion imbalance, white and ...
Chong Wan, Chong Wan, Rui-Yi Zong, Rui-Yi Zong, Xing-Shu Chen   +4 more
doaj   +1 more source

Impaired liver regeneration in mice lacking methionine adenosyltransferase 1A [PDF]

The FASEB Journal, 2004
ABSTRACT Methionine adenosyltransferase (MAT) is an essential enzyme because it catalyzes the formation of S‐adenosylmethionine (SAMe), the principal biological methyl donor. Of the two genes that encode MAT, MAT1A is mainly expressed in adult liver and ...
Corrales, F.J. (Fernando José), Lu, S.C. (Shelly C.), Avila, M.A. (Matías Antonio), Chen, L. (Lixin), Ruiz Garcia-Trevijano, E. (Elena), Lee, T.D. (Taunia D.), Zeng, Y. (Ying), Yang, H. (Heping), Mato, J.M. (José María), French, S.W. (Samuel W.)   +9 more
openaire   +3 more sources

Evolutionary Divergence of an Ethylene‐Responsive Transcriptional Cascade Governs a Dose‐Dependent Balance between Cotton Fiber Length and Strength

Advanced Science, Volume 13, Issue 5, 27 January 2026.
A tunable, ethylene‐responsive cascade governing the dose‐dependent balance between fiber length and strength is unveiled. Elevated ethylene strengthens modern tetraploid cotton (G. hirsutum) fibers but elongates those of its diploid ancestor (G. arboreum). This phenotypic switch is traced to an evolutionary functional inversion of a conserved EIN3‐ERF‐
Jie Zhang, Mengli Yu, Yuling Guo, Jie Li, Gailing Gu, Ghulam Hussain, Shuya Ma, Fuguang Li, Hongwei Xue, Zhaoen Yang, Zuoren Yang   +10 more
wiley   +1 more source

Organophosphorus S-adenosyl-L-methionine mimetics: synthesis, stability, and substrate properties

Frontiers in Chemistry
S-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their function and regulates numerous vital intracellular processes. Analogs of SAM with a reporter group in place of the S-methyl group are widely used to study these processes.
Alexander Yu Rudenko, Alexander Yu Rudenko, Sofia S. Mariasina, Sofia S. Mariasina, Sofia S. Mariasina, Sofia S. Mariasina, Anastasiia K. Bolikhova, Anastasiia K. Bolikhova, Maxim V. Nikulin, Ratislav M. Ozhiganov, Ratislav M. Ozhiganov, Vasiliy G. Vasil’ev, Yuri A. Ikhalaynen, Anastasia L. Khandazhinskaya, Maxim A. Khomutov, Peter V. Sergiev, Peter V. Sergiev, Alex R. Khomutov, Vladimir I. Polshakov   +18 more
doaj   +1 more source

Characterization of Rat Liver-specific Methionine Adenosyltransferase Gene Promoter [PDF]

Journal of Biological Chemistry, 1997
Methionine adenosyltransferase is a ubiquitous enzyme that catalyzes the only known route of biosynthesis of S-adenosylmethionine, the major methyl group donor in cell metabolism. In mammals, two different methionine adenosyltransferases exist: one is confined to the liver, and the other one is distributed in extrahepatic tissues. In the present study,
Álvarez, Luis, Sánchez-Góngora, Estrella, Mingorance, Jesús, Pajares, María Ángeles, Mato, José M.   +4 more
openaire   +2 more sources

Mechanistic Insights and Therapeutic Potential of Small Nucleolar RNA Host Genes in the Carcinogenesis of Hepatocellular Carcinoma

Cancer Medicine, Volume 15, Issue 1, January 2026.
ABSTRACT Background Hepatocellular carcinoma (HCC) is one of the major factors endangering human health due to its poor prognosis, resulting from difficulties in early diagnosis and lack of effective treatment measures. Long non‐coding RNAs (lncRNAs), which are RNA molecules that do not translate into proteins, play essential roles in various tumor ...
Jiajia Luo, Zhangxiu Liao, Shuangxia Zhang   +2 more
wiley   +1 more source

Methionine adenosyltransferase (s-adenosylmethionine synthetase).

Advances in enzymology and related areas of molecular biology, 2012
El pdf es la versión post-print.
Pajares, María Ángeles, Markham, George D.   +1 more
openaire   +2 more sources

The 5′ Cap Epitranscriptome and Beyond: Natural and Engineered 5′ Cap Modifications for Optimizing mRNA Therapeutics and Functional Studies

ChemMedChem, Volume 21, Issue 2, January 2026.
5′ Cap modifications can be introduced via enzymes or chemical synthesis. Natural and non‐natural 5′ cap structures affect mRNA properties, including translation (T), stability (S), and/or immunogenicity (I). Eukaryotic mRNAs made by in vitro transcription have emerged as medical modalities for vaccination and protein replacement therapy. The 5′ cap is
Greta Charlotte Dahm, Melissa Pieper, Helena Schepers, Andrea Rentmeister   +3 more
wiley   +1 more source

Synthetic lethality in cancer therapy: Mechanisms, models and clinical translation for overcoming therapeutic resistance

Clinical and Translational Medicine, Volume 16, Issue 1, January 2026.
Application of synthetic lethality screening in drug resistance models. Abstract Background and Rationale Synthetic lethality (SL)‐based strategies hold significant promise for overcoming therapeutic resistance, a critical bottleneck in cancer treatment where cancer cells evade anticancer therapies, leading to diminished efficacy or treatment failure ...
Junyan Li, Liyuan Zhang, Yan Shang, Juan Liu, Hailong Zhao   +4 more
wiley   +1 more source