Results 41 to 50 of about 4,135 (162)

Methionine adenosyltransferase (MAT) as a biomarker of oxidative stress in hemodialysis patients: assessment before and after dialysis and the effect of repeated treatment [PDF]

مجلة جامعة الانبار للعلوم الصرفة
Chronic kidney disease (CKD) is commonly associated with elevated oxidative stress due to impaired renal clearance of reactive oxygen and nitrogen species. Hemodialysis (HD) may further exacerbate this imbalance.
Rana Atiyah, Faiz AL-abady, Luay Al-Helaly   +2 more
doaj   +1 more source

Dysregulated Hepatic Methionine Metabolism Drives Homocysteine Elevation in Diet-Induced Nonalcoholic Fatty Liver Disease. [PDF]

PLoS ONE, 2015
Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The mechanisms by which these are affected in NAFLD are not fully understood.
Tommy Pacana, Sophie Cazanave, Aurora Verdianelli, Vaishali Patel, Hae-Ki Min, Faridoddin Mirshahi, Eoin Quinlivan, Arun J Sanyal   +7 more
doaj   +1 more source

Changes in the Levels of Methionine Adenosyltransferase, Methionine Sulfoxide Reductase A, and Thioredoxin are Associated with Oxidative Stress in Patients with Hyperthyroidism

Diyala Journal of Medicine
Background: Hyperthyroidism is associated with increased oxidative stress and alterations in enzymatic and non-enzymatic antioxidant systems. Methionine adenosyltransferase (MAT) plays a key role in cellular metabolism and may be involved in redox ...
Marwa A. Al-Badrany, Luay A. Al-Helaly
doaj   +1 more source

Confirmation that MAT1A p.Ala259Val mutation causes autosomal dominant hypermethioninemia

Molecular Genetics and Metabolism Reports, 2017
Methionine adenosyltransferase (MAT) I/III deficiency is an inborn error of metabolism caused by mutations in MAT1A, encoding the catalytic subunit of MAT responsible for the synthesis of S-adenosylmethionine, and is characterized by persistent ...
Michael J. Muriello, Sarah Viall, Teodoro Bottiglieri, Kristina Cusmano-Ozog, Carlos R. Ferreira   +4 more
doaj   +1 more source

First genome sequence of a European Alternaria brassicae isolate and genes involved in early development of alternaria leaf spot on Brassica juncea

Pest Management Science, EarlyView.
This article reports the first genome sequence of a UK Alternaria brassicae isolate. Dual RNA‐sequencing profiling of A. brassicae‐infected Brassica juncea leaves identified differentially expressed genes involved in pathogenicity and host response pathways in moderately resistant Sej‐2 (2) and moderately susceptible Pusa Jaikisan cultivars.
Kevin M. King, Graham McLaughlin, Chinthani S. Karandeni Dewage, Zedi Gao, David J. Hughes, Jonathan S. West, Henrik U. Stotz   +6 more
wiley   +1 more source

Methionine intervention induces PD-L1 expression to enhance the immune checkpoint therapy response in MTAP-deleted osteosarcoma

Cell Reports Medicine
Summary: Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we identify a subgroup of OS with methylthioadenosine ...
Haoran Mu, Qi Zhang, Dongqing Zuo, Jinzeng Wang, Yining Tao, Zhen Li, Xin He, Huanliang Meng, Hongsheng Wang, Jiakang Shen, Mengxiong Sun, Yafei Jiang, Weisong Zhao, Jing Han, Mengkai Yang, Zhuoying Wang, Yu Lv, Yuqin Yang, Jing Xu, Tao Zhang, Liu Yang, Jun Lin, Feng Tang, Renhong Tang, Haiyan Hu, Zhengdong Cai, Wei Sun, Yingqi Hua   +27 more
doaj   +1 more source

S‐Adenosylmethionine (SAM) hydrolases counter increased SAM epimerisation in thermophilic archaea

The FEBS Journal, EarlyView.
S‐Adenosyl‐l‐methionine (SAM) is a vital enzyme cofactor. Epimerisation at the sulfonium centre of biologically active (SS,SCα)‐SAM is driven by heat, yielding biologically inactive (RS,SCα)‐SAM. Here, two novel archaeal SAM hydrolases from the thermophilic Sulfolobus acidocaldarius and the halophilic Haloferax volcanii are shown to cleave (RS,SCα)‐SAM.
Agnes Bartels, Michael K. F. Mohr, Phillip Nußbaum, Marie Joest, Bianca Wassmer, Laurent Rasquin, Sonja‐Verena Albers, Jennifer N. Andexer   +7 more
wiley   +1 more source

S-adenosylmethionine addiction confers sensitivity to methionine restriction in KMT2A-rearranged acute lymphoblastic leukemia

Haematologica
Current intensive chemotherapy regimens have improved overall survival in pediatric acute lymphoblastic leukemia (ALL) but fail to cure some high-risk patient subgroups.
Trisha Tee, Titine J.J. Ruiter, Shuiyan Wu, Weiya Zhang, Dorette van Ingen Schenau, Maria Rodionova, Danique Wajon, Britt M.T. Vervoort, Kari J.T. Grunewald, Marjolein Bosma, Rico Hagelaar, John Baker-Hernandez, Ahmed Dahaoui, Pauline Schneider, Nanda M. Verhoeven-Duif, Laurens T. van der Meer, Frank N. van Leeuwen   +16 more
doaj   +1 more source

Methionine Regulates Antitumour Function of CD8+ T Cells Through Polyamine Synthesis

Immunology, EarlyView.
Methionine restriction in vitro enhances CD8+ T cell effector function by suppressing polyamine synthesis and progressively induces the co‐expression of PD‐1 and TIM‐3. Consistently, sustained dietary methionine restriction diminishes the efficacy of adoptive T cell therapy (ACT) and promotes the expression of terminal exhaustion‐associated markers ...
Tian Zhao, Gillian A. Carleton, Sam Preshaw, Sarah MacPherson, Madison Shiyuk, Joseph Monaghan, Jun Han, Oro Uchenunu, Robert Rottapel, Ralph J. DeBerardinis, Kelly M. Stewart, Bo‐Hyun Kim, Juan Ausió, David R. Goodlett, Helena Pětrošová, Kyle D. Duncan, Julian J. Lum   +16 more
wiley   +1 more source

MAT2A promotes atherosclerotic plaque vulnerability by mediating epigenetic reprogramming of macrophages

Nature Communications
Atherosclerosis is mediated by circulating monocytes and lesional macrophages through chronic inflammation accompanied by metabolic reprogramming. Although methionine metabolism enhances the proinflammatory capacity of monocytes/macrophages, its role in ...
Zhuo Du, Pingping Wan, Manyu Du, Song Li, Qiuying Yan, Sibo Sun, Caiying Tang, Ziquan Jiang, Shuang Li, Guoxia Shi, Baixue Miao, Xiaoyu Du, Shilong Li, Shaohong Fang, Chao Wang, Chao Fang, Bo Yu, Jiannan Dai, Ping Sun   +18 more
doaj   +1 more source