Results 21 to 30 of about 4,135 (162)
Determination of Autosomal Dominant or Recessive Methionine Adenosyltransferase I/III Deficiencies Based on Clinical and Molecular Studies [PDF]
Molecular Medicine, 2016 Methionine adenosyltransferase (MAT) I/III deficiency can be Inherited as autosomal dominant (AD) or as recessive (AR) traits in which mono- or biallelic MAT1A mutations have been identified, respectively.
Yoo-Mi Kim +11 more
doaj +2 more sources
Crystallography captures catalytic steps in human methionine adenosyltransferase enzymes [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 2016 Alberto Marina +2 more
exaly +2 more sources
Methionine adenosyltransferases in liver cancer [PDF]
World Journal of Gastroenterology, 2019 Methionine adenosyltransferases (MATs) are essential enzymes for life as they produce S-adenosylmethionine (SAMe), the biological methyl donor required for a plethora of reactions within the cell. Mammalian systems express two genes, MAT1A and MAT2A, which encode for MATα1 and MATα2, the catalytic subunits of the MAT isoenzymes, respectively.
Murray, Ben +4 more
openaire +3 more sources
Activation of MAT2A-RIP1 signaling axis reprograms monocytes in gastric cancer
Journal for ImmunoTherapy of Cancer, 2021 Background The activation of tumor-associated macrophages (TAMs) facilitates the progression of gastric cancer (GC). Cell metabolism reprogramming has been shown to play a vital role in the polarization of TAMs. However, the role of methionine metabolism
Xi Yang +7 more
doaj +1 more source
Regulation of Mammalian Liver Methionine Adenosyltransferase [PDF]
The Journal of Nutrition, 2002 S-adenosylmethionine (SAM) is an essential metabolite in all cells. SAM is the most important biological methyl group donor and is a precursor in the synthesis of polyamines. Methionine adenosyltransferase (MAT; EC 2.5.1.6) catalyzes the only known SAM biosynthetic reaction from methionine and ATP.
Latasa, M.U. (María Ujué) +10 more
openaire +3 more sources
iScience, 2023 Summary: Methionine adenosyltransferase 1a (MAT1A) is responsible for hepatic S-adenosyl-L-methionine (SAMe) biosynthesis. Mat1a−/− mice have hepatic SAMe depletion, develop nonalcoholic steatohepatitis (NASH) which is reversed with SAMe administration ...
Aaron E. Robinson +16 more
doaj +1 more source
Structure-function relationships in methionine adenosyltransferases [PDF]
Cellular and Molecular Life Sciences, 2008 Methionine adenosyltransferases (MATs) are the family of enzymes that synthesize the main biological methyl donor, S-adenosylmethionine. The high sequence conservation among catalytic subunits from bacteria and eukarya preserves key residues that control activity and oligomerization, which is reflected in the protein structure.
G D, Markham, M A, Pajares
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Characterisation of methionine adenosyltransferase from
BMC Microbiology, 2003 Background Tuberculosis remains a serious world-wide health threat which requires the characterisation of novel drug targets for the development of future antimycobacterials.
Knodel Marvin H, Berger Bradley J
doaj +1 more source
Consequences of the divergence of Methionine AdenosylTransferase [PDF]
, 2020 Abstract Methionine adenosyltransferase (MAT), which catalyzes the biosynthesis of S-adenosylmethionine from L-methionine and ATP, is an ancient, highly conserved enzyme present in all three domains of life. Although the MAT enzymes of each domain are believed to share a common ancestor, the sequences of archaeal MATs show a high degree
Bhanupratap Singh Chouhan +4 more
openaire +1 more source
Knockdown of METTL16 disrupts learning and memory by reducing the stability of MAT2A mRNA
Cell Death Discovery, 2022 N6-methyladenosine (m6A) is abundant in the mammalian brain and is considered to have a wide range of effects on learning and memory. Here, we found that the upregulated methyltransferase-like protein 16 (METTL16) in the hippocampal tissues of Morris ...
Runjiao Zhang +10 more
doaj +1 more source