Results 11 to 20 of about 4,135 (162)

Methionine adenosyltransferase I/III deficiency: beyond the central nervous system manifestations [PDF]

Therapeutics and Clinical Risk Management, 2018
Marwan Nashabat,1 Sultan Al-Khenaizan,2 Majid Alfadhel1 1King Abdullah International Medical Research Centre, King Saud bin Abdulaziz University for Health Sciences, Division of Genetics, Department of Pediatrics, King Abdulaziz Medical City, Ministry ...
Nashabat M, Al-Khenaizan S, Alfadhel M
doaj   +2 more sources

Impact of glutathione supplementation of parenteral nutrition on hepatic methionine adenosyltransferase activity [PDF]

Redox Biology, 2016
Background: The oxidation of the methionine adenosyltransferase (MAT) by the combined impact of peroxides contaminating parenteral nutrition (PN) and oxidized redox potential of glutathione is suspected to explain its inhibition observed in animals.
Wesam Elremaly, Ibrahim Mohamed, Thérèse Rouleau, Jean-Claude Lavoie   +3 more
doaj   +2 more sources

Methionine Adenosyltransferase Inhibitors for the Treatment of Cancer. [PDF]

ACS Med Chem Lett, 2021
Kargbo RB.
europepmc   +4 more sources

Role of methionine adenosyltransferase 2A in bovine preimplantation development and its associated genomic regions [PDF]

Scientific Reports, 2017
Methionine adenosyltransferase (MAT) is involved in folate-mediated one-carbon metabolism, which is essential for preimplantation embryos in terms of both short-term periconceptional development and long-term phenotypic programming beyond the ...
Shuntaro Ikeda, Ryouka Kawahara-Miki, Hisataka Iwata, Miki Sugimoto, Shinichi Kume   +4 more
doaj   +2 more sources

MTAP Deficiency as a Metabolic Vulnerability in Cancer: Implications for Synthetic Lethal Therapy. [PDF]

Cancer Sci
MTAP deletion creates a therapeutically actionable metabolic vulnerability through MTA accumulation and PRMT5 dependency. This review summarizes the biochemical basis of MTAP‐directed synthetic lethality, emerging PRMT5/MAT2A inhibitors, clinicogenomic features of MTAP‐deleted tumors, and future strategies for precision oncology.
Ikushima H, Kage H.
europepmc   +2 more sources

The role of forkhead box M1-methionine adenosyltransferase 2 A/2B axis in liver inflammation and fibrosis [PDF]

Nature Communications
Methionine adenosyltransferase 2 A (MAT2A) and MAT2B are essential for hepatic stellate cells (HSCs) activation. Forkhead box M1 (FOXM1) transgenic mice develop liver inflammation and fibrosis. Here we examine if they crosstalk in male mice.
Bing Yang, Liqing Lu, Ting Xiong, Wei Fan, Jiaohong Wang, Lucía Barbier-Torres, Jyoti Chhimwal, Sonal Sinha, Takashi Tsuchiya, Nirmala Mavila, Maria Lauda Tomasi, DuoYao Cao, Jing Zhang, Hui Peng, José M. Mato, Ting Liu, Xi Yang, Vladimir V. Kalinichenko, Komal Ramani, Jenny Han, Ekihiro Seki, Heping Yang, Shelly C. Lu   +22 more
doaj   +2 more sources

Identification of a natural inhibitor of methionine adenosyltransferase 2A regulating one-carbon metabolism in keratinocytesResearch in context [PDF]

EBioMedicine, 2019
Background: Psoriasis is a common chronic inflammatory skin disease which lacks effective strategies for the treatment. Natural compounds with biological activities are good tools to identify new targets with therapeutic potentials.
Jing Bai, Yuanyuan Gao, Linjiao Chen, Qianqian Yin, Fangzhou Lou, Zhikai Wang, Zhenyao Xu, Hong Zhou, Qun Li, Wei Cai, Yang Sun, Liman Niu, Hong Wang, Zhenquan Wei, Shaoyong Lu, Aiwu Zhou, Jian Zhang, Honglin Wang   +17 more
doaj   +2 more sources

Biosynthesis of S-Adenosylmethionine by Magnetically Immobilized Escherichia coli Cells Highly Expressing a Methionine Adenosyltransferase Variant [PDF]

Molecules, 2017
S-Adenosylmethionine (SAM) is a natural metabolite having important uses in the treatment of various diseases. To develop a simple and effective way to produce SAM, immobilized Escherichia coli cells highly expressing an engineered variant of methionine ...
Chunli Yin, Tao Zheng, Xin Chang
doaj   +2 more sources

S-Adenosyl-d-Methionine as a Non-Physiological Substrate for a Wide Range of SAM-Dependent Enzymes. [PDF]

Chembiochem
From methylation and cyclisation to radical chemistry, diverse enzyme classes utilise the non‐canonical cofactor d‐SAM. These findings reveal an unexpected tolerance of SAM‐dependent catalysis towards inversion of the methionine Cα stereocentre. The ability of SAM‐dependent enzymes to accept S‐adenosyl‐d‐methionine [d‐SAM, (SS,RCα)‐SAM] instead of the ...
Germer P, Gericke L, Koeppl LH, Zou Z, Jockmann E, Kuge M, Zoller K, Herrmann H, Fuderer R, Mohr MKF, Bartels A, Oral G, Lukat P, Layer G, Müller M, Blankenfeldt W, Barra L, Andexer JN.   +17 more
europepmc   +2 more sources

Thoracic Aortic Dissection in a Patient With Classical Homocystinuria: Implications for Aortic Surveillance. [PDF]

JIMD Rep
ABSTRACT Classical homocystinuria (OMIM #236300), a rare inherited metabolic disorder caused by cystathionine beta‐synthase (CBS) deficiency, is characterized by markedly elevated homocysteine levels and associated multisystem complications. While the role of homocystinuria in venous thromboembolism is well recognized, there is limited evidence of ...
Chard M, Zhang JS, Turner L.
europepmc   +2 more sources