Results 61 to 70 of about 4,135 (162)

Vitamin‐Responsive Disorders: From Molecular Basis to Clinical Presentation and Therapy

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
ABSTRACT Vitamin‐dependent cofactors are essential for numerous metabolic reactions, and defects affecting their uptake, conversion, utilisation, or regeneration constitute a heterogeneous group of inherited metabolic disorders (IMDs). Although dietary vitamin intake is sufficient to sustain coenzyme synthesis in healthy individuals, it is insufficient
Cécile Acquaviva, Yann Nadjar, Manuel Schiff, Christine Vianey‐Saban, Alain Fouilhoux, Jean‐François Benoist   +5 more
wiley   +1 more source

Organophosphorus S-adenosyl-L-methionine mimetics: synthesis, stability, and substrate properties

Frontiers in Chemistry
S-Adenosyl-l-methionine (SAM)-mediated methylation of biomolecules controls their function and regulates numerous vital intracellular processes. Analogs of SAM with a reporter group in place of the S-methyl group are widely used to study these processes.
Alexander Yu Rudenko, Alexander Yu Rudenko, Sofia S. Mariasina, Sofia S. Mariasina, Sofia S. Mariasina, Sofia S. Mariasina, Anastasiia K. Bolikhova, Anastasiia K. Bolikhova, Maxim V. Nikulin, Ratislav M. Ozhiganov, Ratislav M. Ozhiganov, Vasiliy G. Vasil’ev, Yuri A. Ikhalaynen, Anastasia L. Khandazhinskaya, Maxim A. Khomutov, Peter V. Sergiev, Peter V. Sergiev, Alex R. Khomutov, Vladimir I. Polshakov   +18 more
doaj   +1 more source

Methionine Synthase Interacts With the Methionine Adenosyl‐Transferase MATα2 and the DNA Methyltransferase DNMT3b in the Nucleus

Journal of Inherited Metabolic Disease, Volume 49, Issue 4, July 2026.
This study shows that methionine synthase (MS) interacts with MATα2, responsible for SAM production, and the methyltransferase DNMT3b in the nucleus. These results support the idea that spatial compartmentalization of one‐carbon metabolism could play a major role in regulating the epigenome.
Manon Jeandel, Jean‐Marc Alberto, Okan Baspinar, Aurélie Robert, Natacha Dreumont, Zeinab Alsahly, David Meyre, Jean‐Louis Guéant, David Coelho   +8 more
wiley   +1 more source

The SMYD3-dependent H3K4me3 status of IGF2 intensifies local Th2 differentiation in CRSwNP via positive feedback

Cell Communication and Signaling, 2023
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous and common upper airway disease divided into various inflammatory endotypes. Recent epidemiological findings showed a T helper 2 (Th2)-skewed dominance in CRSwNP patients.
Lei Yu, Yi Wei, Tong Lu, Zhengqi Li, Shimin Lai, Yan Yan, Changhui Chen, Weiping Wen   +7 more
doaj   +1 more source

Nicotinamide N‐Methyltransferase Epigenetically Activates Fibronectin 1 Through H3K9me3 Remodeling in Clear Cell Renal Cell Carcinoma

MedComm, Volume 7, Issue 7, July 2026.
Upregulation of NNMT in ccRCC is associated with tumor stage and poor prognosis. Mechanistically, NNMT reduces SAM levels, thereby decreasing H3K9me3 modification and promoting FN1 transcription. NNMT inhibitor effectively suppresses tumor progression, providing compelling evidence for its potential as a novel target for therapeutic intervention in ...
Lingling Wang, Yueyang Wang, Qizheng Han, Xiao Zhou, Chenxia Wu, Honghe Zhang, Zhiyong Liang, Maode Lai   +7 more
wiley   +1 more source

Effect of Fasting on Methionine Adenosyltransferase Expression and the Methionine Cycle in the Mouse Liver

Journal of Nutritional Science and Vitaminology, 2005
The effect of fasting on mouse liver methionine adenosyltransferase (MAT I/ III) expression and the regulation of methionine metabolism were investigated. The mRNA level, protein level, and activity of MAT I/III were increased by fasting for 10 or 16 h.
SAKATA, Shigeko Fujimoto, OKUMURA, Sonomi, MATSUDA, Koichi, HORIKAWA, Yoko, MAEDA, Mitsuko, KAWASAKI, Koichi, CHOU, Janice Yang, TAMAKI, Nanaya   +7 more
openaire   +3 more sources

Scotty: lattice coincidences in the Protein Data Bank

Acta Crystallographica Section D, Volume 82, Issue 7, Page 824-835, July 2026.
Scotty supports crystallographic comparisons of lattice coincidences, the interpretation of oligomeric assemblies and paracrystallinity.The application Scotty, implemented within the Phasertng codebase, was used to perform a PDB‐wide analysis of lattice coincidences.
Airlie J. McCoy, Lawrence C. Andrews, Herbert J. Bernstein, Randy J. Read   +3 more
wiley   +1 more source

NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.

PLoS ONE, 2012
Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates.
Beatriz González, Francisco Garrido, Rebeca Ortega, Marta Martínez-Júlvez, Ainhoa Revilla-Guarinos, Yolanda Pérez-Pertejo, Adrián Velázquez-Campoy, Julia Sanz-Aparicio, María A Pajares   +8 more
doaj   +1 more source

Histidine Ethylation by Histidine Methyltransferases SETD3 and METTL9

ChemBioChem, Volume 27, Issue 12, 26 June 2026.
Enzyme assays and computational analyses reveal that human histidine methyltransferases SETD3 and METTL9 have a capacity to catalyze histidine ethylation in the presence of synthetic or in situ produced S‐adenosylethionine (AdoEth) and Se‐adenosylselenoethionine (AdoSeEth) cosubstrates.
Jordi C. J. Hintzen, Zhimei Yu, Sadaf Ahmad, Xin Zhang, Yuan–Yuan Zhao, Hao Deng, Leonie Schütz, Marija Ram, Julia Z. Kaminska, Jakub Drozak, Elmar Weinhold, Hong Guo, Andrea Rentmeister, Ping Qian, Jasmin Mecinović   +14 more
wiley   +1 more source

Genomic Map of Escherichia coli and Single Nucleotide Polymorphism Markers in Colorectal Cancer

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
This study identified colorectal cancer‐associated SNPs in Escherichia coli using PacBio full‐genome sequencing, establishing a highly accurate SNP‐based model for non‐invasive colorectal cancer risk prediction. ABSTRACT Gut microbial single nucleotide polymorphisms (SNPs) offer stable, specific genetic markers for disease diagnosis.
Yang Xi, Zhong Liping, Xu Yating, Xu Yang, Chu Jian, Chu Caiyun, Li Shuwen, Zhang Zian, Yu Xiaojian, Han Shuwen, Wu Wei   +10 more
wiley   +1 more source