Results 71 to 80 of about 3,813 (143)

Reversing Acute Cardiomyopathy With Coenzyme Q10 Supplementation in Cobalamin B Disease: A Case Report and Literature Review

JIMD Reports, Volume 67, Issue 1, January 2026.
ABSTRACT Methylmalonic acidemia (MMA) is a rare metabolic disorder with various subtypes, including Cobalamin B (cblB) disease. While cardiac complications are well‐documented in propionic acidemia, their occurrence in MMA is less understood. Here, we report a 12‐year‐old child with cblB disorder who developed acute cardiomyopathy (CM).
Dalia Said, Aisha Al Shamsi
wiley   +1 more source

MicroRNAs regulate methionine adenosyltransferase 1A expression in hepatocellular carcinoma [PDF]

Journal of Clinical Investigation, 2012
MicroRNAs (miRNAs) and methionine adenosyltransferase 1A (MAT1A) are dysregulated in hepatocellular carcinoma (HCC), and reduced MAT1A expression correlates with worse HCC prognosis. Expression of miR-664, miR-485-3p, and miR-495, potential regulatory miRNAs of MAT1A, is increased in HCC.
Heping, Yang, Michele E, Cho, Tony W H, Li, Hui, Peng, Kwang Suk, Ko, Jose M, Mato, Shelly C, Lu   +6 more
openaire   +2 more sources

Homocysteine Exacerbates Pulmonary Fibrosis via Orchestrating Syntaxin 17 Homocysteinylation of Alveolar Type II Cells

Advanced Science, Volume 12, Issue 46, December 11, 2025.
The study identifies elevated homocysteine (Hcy) levels in idiopathic pulmonary fibrosis patients' samples, with alveolar type 2 cells as the primary site of Hcy metabolism. Methionine synthase reductase downregulation in these cells exacerbates fibrosis, while folate administration reduces Hcy levels and alleviates fibrosis.
Jiefeng Huang, Ke Fang, Wuyan Lu, Rongrong Wu, Yuanyuan Chen, Linxiao Li, Zihao Hu, Zixin Cai, Yu Jiang, Xinli Fan, Jinyi Deng, Guangpeng Liu, Zhuang Luo, Lei Cui, Shuaijun Li   +14 more
wiley   +1 more source

NADP+ binding to the regulatory subunit of methionine adenosyltransferase II increases intersubunit binding affinity in the hetero-trimer.

PLoS ONE, 2012
Mammalian methionine adenosyltransferase II (MAT II) is the only hetero-oligomer in this family of enzymes that synthesize S-adenosylmethionine using methionine and ATP as substrates.
Beatriz González, Francisco Garrido, Rebeca Ortega, Marta Martínez-Júlvez, Ainhoa Revilla-Guarinos, Yolanda Pérez-Pertejo, Adrián Velázquez-Campoy, Julia Sanz-Aparicio, María A Pajares   +8 more
doaj   +1 more source

Short-chain ceramide regulates hepatic methionine adenosyltransferase expression

Journal of Hepatology, 2001
The metabolism of methionine plays an important role in regulating hepatic cellular function. Methionine adenosyltransferase (MAT) is the enzyme that catalyses the biosynthesis of S-adenosylmethionine (AdoMet) from ATP and methionine. Liver-specific MAT I/III levels are down-regulated in the regenerating rat liver after partial hepatectomy.
Frago, Laura M., Pañeda, Covadonga, Fabregat, Isabel, Varela-Nieto, Isabel   +3 more
openaire   +3 more sources

Localization of the PE methylation pathway and SR-BI to the canalicular membrane

Journal of Lipid Research, 2003
To better understand the regulation of biliary phospholipid and cholesterol excretion, canalicular membranes were isolated from the livers of C57BL/6J mice and abundant proteins separated by SDS-PAGE and identified by matrix-assisted laser desorption ...
Ephraim Sehayek, Rong Wang, Jennie G. Ono, Vadim S. Zinchuk, Elizabeth M. Duncan, Sarah Shefer, Dennis E. Vance, Meenakshisundaram Ananthanarayanan, Brian T. Chait, Jan L. Breslow   +9 more
doaj   +1 more source

Rewriting the MASLD‐associated hepatocellular carcinoma script: Targeting epigenetics and metabolism

International Journal of Cancer, Volume 157, Issue 10, Page 1991-2003, 15 November 2025.
Abstract Abnormal epigenetic patterns are crucial for the progression of metabolic‐associated steatotic liver disease (MASLD) and hepatocellular carcinoma (HCC) development. Recent research focused on the interplay between epigenetics and altered metabolic pathways in HCC from MASLD, suggesting that the reversibility of epigenetic changes offers ...
Chiara Aiello, Eric Felli, Teresa Musarra, Lorenzo Nevi, Annamaria Altomare, Jordi Gracia‐Sancho, Andrea Baiocchini, Simone Carotti   +7 more
wiley   +1 more source

MTAP Deletions in Cancer Create Vulnerability to Targeting of the MAT2A/PRMT5/RIOK1 Axis

Cell Reports, 2016
Homozygous deletions of p16/CDKN2A are prevalent in cancer, and these mutations commonly involve co-deletion of adjacent genes, including methylthioadenosine phosphorylase (MTAP).
Katya Marjon, Michael J. Cameron, Phong Quang, Michelle F. Clasquin, Everton Mandley, Kaiko Kunii, Michael McVay, Sung Choe, Andrew Kernytsky, Stefan Gross, Zenon Konteatis, Joshua Murtie, Michelle L. Blake, Jeremy Travins, Marion Dorsch, Scott A. Biller, Kevin M. Marks   +16 more
doaj   +1 more source

Anaerobic Limonene Metabolism in a Methanogenic Enrichment Involves a Glycine Radical Enzyme

Environmental Microbiology, Volume 27, Issue 11, November 2025.
A methanogenic enrichment culture on the natural monoterpene limonene is characterised by a novel glycine radical enzyme for anaerobic hydrocarbon activation, the presence of a microbial loop for necromass utilisation and the presence of a predator of Bacteria and Archaea. ABSTRACT Limonene is a natural monoterpene omnipresent in human environments. It
Almud Lonsing, Gerrit Alexander Martens, Anastasia Resteu, Jana Kizina, Isabella Wilkie, Alexandra Bahr, Jens Harder   +6 more
wiley   +1 more source

Altered Arginine Metabolism in Children Undergoing Fontan Palliation: A Prospective Cohort Study

Pulmonary Circulation, Volume 15, Issue 4, October 2025.
ABSTRACT Children with single ventricle heart disease (SVHD) demonstrate decreased arginine/NO metabolism following Stage 2 (Glenn) palliation, associated with poor postoperative outcomes. It is unknown if arginine dysregulation persists at Stage 3 (Fontan).
Benjamin S. Frank, Sierra Niemiec, Ludmila Khailova, Christopher A. Mancuso, Tanner Lehmann, Gareth J. Morgan, Michael V. DiMaria, Carmen C. Sucharov, Jelena Klawitter, Jesse A. Davidson   +9 more
wiley   +1 more source