Results 161 to 170 of about 107,753 (225)

The paradoxical role of methionine enkephalin in tumor responses

European Journal of Pharmacology, 2020
Methionine enkephalin (MENK) is an opioid peptide composed of five amino acids with multiple biological activities. Since its discovery, MENK has become prominent in neuroregulation and immunoregulation. Tumors have increasingly been a spotlight because of their terrible trends and refractory characteristic.
Cheng Tian, Ming Xiang, Yali Tuo, Lili Lu   +3 more
openaire   +4 more sources

Methionine‐enkephalin peptides in human teeth

International Journal of Peptide and Protein Research, 1988
The presence of the free opioid pentapeptide methionine enkephalin (ME) and of ME‐containing peptide(s) was established firmly in decalcified, depulped human teeth by using a combination of methods including RP‐HPLC, radioimmunoassay, radioreceptorassay, trypsin, carboxypeptidase B, fast atom bombardment mass spectrometry, and MS/MS methodology ...
Dominic M. Desiderio, Peter W. Tinsley, Francis S. Tanzer, Genevieve H. Fridland, John T. Killmar, Chhabil Dass, Emirgul Tolun   +6 more
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METHIONINE ENKEPHALIN AND ISOSTERIC ANALOGUES

International Journal of Peptide and Protein Research, 1980
Biological activities are reported for two different types of analogues of methionine enkephalin. Cyclic analogues, bridged between the amino‐ and carboxy‐ terminals of the parent peptide, are inactive. In contrast, significant levels of activity are displayed by linear isosterically modified analogues in which the Tyr1 ‐Gly2 peptide bond is replaced ...
Robert Sharpe, Derek Hudson, Michael Szelke   +2 more
openaire   +3 more sources

Methionine enkephalin regulates microglia polarization and function

International Immunopharmacology, 2016
Methionine enkephalin (MENK), an opioid peptide, is known to function as a regulator in the immune system. As microglia are considered the most important immune cells in the central nervous system (CNS), we aimed to assess the function of MENK on microglia polarization and tumoricidal responses.
Lulu Wen, Xuxu Xu, Juan Feng, Zhiyong Zhai, Fengping Shan, Shuo Zhang, Yan Gao   +6 more
openaire   +3 more sources

Biosynthetic origin and receptor conformation of methionine enkephalin

Nature, 1976
RECENT reports have shown that the brain contains an endogenous peptide with opiate-like activity1–3 and similar peptides have been found in the pituitary4,5,13. One of the brain peptides, known as methionine enkephalin, was identified as a pentapeptide Tyr–Gly–Gly–Phe–Met6, and evidence was presented that a minor component may have leucine in place of
C. R. Snell, Derek G. Smyth, A.F. Bradbury   +2 more
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Methionine-enkephalin, leucine-enkephalin, methionine-enkephalin-Arg6-Phe7 and methionine-enkephalin-Arg6-Gly7-Leu8 in human pheochromocytoma

Life Sciences, 1983
Methionine-enkephalin(met-enkephalin)-, leucine-enkephalin(leu-enkephalin)-, methionine-enkephalin-Arg6-Phe7(met-enkephalin-Arg-Phe)- and methionine-enkephalin-Arg6-Gly7-Leu8(met-enkephalin-Arg-Gly-Leu)-like immunoreactivities(-LI) were studied in 16 pheochromocytomas by radioimmunoassays (RIAs) for these four opioid peptides. Met-enkephalin-Arg-Phe-LI
Yoshio Ikeda, Takaaki Yoshimasa, Mitsuaki Suda, Kazuwa Nakao, Makoto Sakamoto, Hiroo Imura   +5 more
openaire   +3 more sources

Demonstration and characterization of immunoreactive methionine-enkephalin, leucine-enkephalin, methionine-enkephalin-Arg6-Gly7-Leu8 and methionine-enkephalin-Arg6-Phe7 in human phaeochromocytoma

Acta Endocrinologica, 1984
Abstract. To elucidate whether or not human phaeochromocytoma contains methionine-enkephalin-Arg6-Gly7-Leu8 (Met-enkephalin-Arg-Gly-Leu) and methionine-enkephalin-Arg6-Phe7 (Met-enkephalin-Arg-Phe) together with methionine-enkephalin (Met-enkephalin) and leucine-enkephalin (Leu-enkephalin), all of which are known to exist in the same precursor molecule
Shinichiro Shimbo, Takashi Ishihara, Satoshi Hamada, Yoshio Ikeda, Hiroo Imura, Shigeru Matsukura, Kazuwa Nakao, Mitsuaki Suda, Masataka Manno, Narito Morii, Teruya Yoshimi, Takaaki Youshimasa, Makoto Sakamoto, Toru Mori   +13 more
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Parallel distribution of methionine-enkephalin-arg6-gly7-leu8 with methionine-enkephalin, leucine-enkephalin and methionine-enkephalin-arg6-phe7 in human and bovine brains

Life Sciences, 1983
Using specific radioimmunoassays(RIAs) for methionine-enkephalin(Met-Enk), leucine-enkephalin(Leu-Enk), methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg-Gly-Leu) and methionine-enkephalin-Arg6-Phe7 (Met-Enk-Arg-Phe), we studied the regional distribution of these opioid peptides in human and bovine brains.
Takaaki Yoshimasa, Noboru Yanaihara, Yoshio Ikeda, Makoto Sakamoto, Hiroo Imura, Mitsuaki Suda, Kazuwa Nakao   +6 more
openaire   +3 more sources

Crystal structure of methionine-enkephalin

Biochemical and Biophysical Research Communications, 1986
The crystal structure of methionine-enkephalin has been determined by X-ray crystallography. There are two independent pentapeptides in the asymmetric unit and both display extended backbone conformations with their side chains arranged alternately below and above the backbone plane.
Norman Camerman, Arthur Camerman, Donald Mastropaolo   +2 more
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OCCURRENCE OF METHIONINE-ENKEPHALIN-ARG6-GLY⁷-LEU⁸WITH METHIONINE-ENKEPHALIN, LEUCINE-ENKEPHALIN AND METHIONINE-ENKEPHALIN-ARG6-PHE⁷IN HUMAN GASTRIC ANTRUM.

The Journal of Clinical Endocrinology & Metabolism, 1983
Recent studies on the nucleotide sequence of cloned DNA complementary to mRNA for preproenkephalin from bovine adrenal medulla and human pheochromocytoma have revealed that this precursor molecule contains four copies of methionine-enkephalin (Met-Enk) and one copy each of leucine-enkephalin (Leu-Enk), methionine-enkephalin-Arg6-Gly7-Leu8 (Met-Enk-Arg6-
Kosho Takasu, Yoshio Ikeda, Shinichiro Shimbo, Hiroo Imura, Kazuwa Nakao, Takaaki Yoshimasa, Noboru Yanaihara, Mitsuaki Suda, Makoto Sakamoto   +8 more
openaire   +2 more sources