Results 191 to 200 of about 107,753 (225)

Proton Magnetic Resonance Studies of Methionine Enkephalin

Biochemical and Biophysical Research Communications, 1996
In the literature there exist two conflicting pieces of data concerning the thermodynamics of the Cu(2+)-methionine enkephalin complex. One study utilized 1H nuclear magnetic resonance (NMR) to study the solution phase Cu(2+)-enkephalin binding and reported a strong interaction over a wide pH range. Another study utilized potentiometry to measure a log
Peter Tonui, S. S. Toporek, Angela Miller, Dave Powell, Thomas J. Manning   +4 more
openaire   +3 more sources

Selective protection of methionine enkephalin released from brain slices by enkephalinase inhibition.

Science, 1981
Methionine enkephalin release was evoked by depolarization of slices from rat striatum with potassium. In the presence of 0.1 microM thiorphan [(N(R,S)-3-mercapto-2-benzylpropionyl)glycine], a potent inhibitor of enkephalin dipeptidyl carboxypeptidase ...
G. Patey, S. de la Baume, J. Schwartz, C. Gros, B. Roques, M. Fournie-Zaluski, E. Soroca-Lucas   +6 more
semanticscholar   +1 more source

Self-administration of methionine enkephalin into the nucleus accumbens

Pharmacology Biochemistry and Behavior, 1984
Microinfusions of the endogenous opiate neurohumor, methionine enkephalin, into the nucleus accumbens initiated a reinforcing stimulus in a dose-related manner. The reinforcing nature of this intracranial self-administration was evaluated with intermittent schedules of reinforcement and a two-lever discrimination procedure.
John D. Lane, Nicholas E. Goeders, James E. Smith   +2 more
openaire   +2 more sources

Metkephamid, a systemically active analog of methionine enkephalin with potent opioid alpha-receptor activity.

Science, 1981
Metkephamid is an analog of methionine enkephalin that retains high affinity for the delta receptor and is a systemically active analgesic. Since it is at least 100 times more potent than morphine as an analgesic when placed directly into the lateral ...
R. Frederickson, E. L. Smithwick, R. Shuman, K. Bemis   +3 more
semanticscholar   +1 more source

Methionine-enkephalin and vasopressin in SHR: effects of dehydration

American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 1986
Enkephalins are found in the posterior pituitary, can alter vasopressin secretion, and have greater pressor effects in spontaneously hypertensive rats (SHR) than in Wistar-Kyoto (WKY) rats. Measurement of the plasma methionine-enkephalin concentration (PMet-Enk) has provided equivocal results in humans and has not been reported in rats.
Joan T. Crofton, Leonard Share, D. P. Brooks, K. Ota   +3 more
openaire   +3 more sources

Localization of methionine‐enkephalin, substance P, and somatostatin immunoreactivities in the main olfactory bulb of the hamster

The Journal of comparative neurology, 1982
Methionine‐enkephalin, substance P, and somatostatin immunoreactivities are associated with different classes of neurons in the main olfactory bulb of the hamster.
B. J. Davis, G. D. Burd, F. Macrides
semanticscholar   +1 more source

Amino-terminal extension analogs of methionine-enkephalin

Biochemical and Biophysical Research Communications, 1978
Abstract Five NH 2 -terminal extension analogs of methionine-enkephalin have been synthesized by solid phase methodology and their morphinomimetic activity determined in the guinea pig ileum-myenteric plexus preparation. Relative to methionine-enkephalin which corresponds to β-LPH-(61–65) and arbitrarily assigned a potency value of 100, β-LPH-(60–65),
Roger Guillemin, Scott Minick, Nicholas Ling   +2 more
openaire   +3 more sources

Regional Distribution of Methionine‐Enkephalin‐Arg6‐Phe7 in the Rat Brain: Comparative Study with the Distribution of Other Opioid Peptides

Journal of Neurochemistry, 1983
: The distribution of the opioid peptide methionine‐enkephalin‐arginine6‐phenylalanine7 (M‐Enk‐Arg6‐Phe7) has been investigated in various structures of the rat brain by using a highly specific radioimmunoassay (RIA).
P. Giraud, E. Castanas, G. Patey, C. Oliver, J. Rossier   +4 more
semanticscholar   +1 more source

Methionine Enkephalin, But not Leucine Enkephalin, is Excreted in Bile [PDF]

Clinical Science, 1988
M S Losowsky, Judith Thornton
openaire   +1 more source

Determination of Methionine-Enkephalin and Leucine-Enkephalin in Human Cerebrospinal Fluid

1983
Abstract Commercially available radio immunoassay kits were used to find out the concentrations of met-enkephalin and leu-enkephalin in the human concentrated CSF samples in the presence of seven proteinase inhibitors. Reference values were established for lumbar CSF. No correlation was found between total protein content and both enkephalins in CSF.
A. Singh, B. Merten, T.O. Kleine
openaire   +2 more sources