Results 71 to 80 of about 107,753 (225)
arXiv, 2013 Present day data allow significant reconsideration of ideas on mechanisms underlying the degeneracy in the genetic code. Here a hypothesis is presented which links the degeneracy to possible conformational alterations in the codon-anticodon duplex. This enables explanation of Rumer symmetry in the table of the genetic code, coding of methionine and ...
arxiv
Mechanism of action of pseudopteroxazole and pseudopterosin G: Diterpenes from marine origin
PROTEOMICS, Volume 24, Issue 10, May 2024.Abstract Pseudopteroxazole (Ptx) and the pseudopterosins are marine natural products with promising antibacterial potential. While Ptx has attracted interest for its antimycobacterial activity, pseudopterosins are active against several clinically relevant pathogens. Both compound classes exhibit low cytotoxicity and accessibility to targeted synthesis,
Niklas B. M. Janzing +6 more
wiley +1 more source
Journal of Extracellular Biology, Volume 3, Issue 4, April 2024.Abstract Isolation of extracellular vesicles (EV) has been developing rapidly in parallel with the interest in EVs. However, commonly utilized protocols may not suit more challenging sample matrixes and could potentially yield suboptimal results. Knowing and assessing the pitfalls of isolation procedure to be used, should be involved to some extent for
Santeri Kankaanpää +11 more
wiley +1 more source
Food Frontiers, Volume 5, Issue 2, Page 820-832, March 2024.Highlights: 1. The optimal conditions for the production of ACEIPs using Lactobacillus Pentosis were optimized. 2. MALDI–TOF–MS and LC–MS/MS were used to identify ACEIPs. 3. Molecular docking techniques were used to predict interactions between ACE and ACEIPs.
Wenjun Li +9 more
wiley +1 more source
Multi-Overlap Simulations for Transitions between Reference Configurations [PDF]
, 2003 We introduce a new procedure to construct weight factors, which flatten the probability density of the overlap with respect to some pre-defined reference configuration. This allows one to overcome free energy barriers in the overlap variable. Subsequently, we generalize the approach to deal with the overlaps with respect to two reference configurations
arxiv +1 more source
Advanced Science, Volume 11, Issue 8, February 23, 2024.This review gives an overview of the latest research on how the sympathetic nervous system impacts key metabolic organs like the pancreas, liver, intestine, and adipose tissues. It highlights the sympathetic innervation and its interactions with the immune components, offering insights into metabolic regulation and potential therapies.
Wenran Ren +3 more
wiley +1 more source
Mechanisms and treatment of opioid‐induced pruritus: Peripheral and central pathways
European Journal of Pain, Volume 28, Issue 2, Page 214-230, February 2024.Abstract Background and Objective Pruritus (also known as itch) is defined as an unpleasant and irritating sensation of the skin that provokes an urge to scratch or rub. It is well known that opioid administration can cause pruritus, which is paradoxical as itch and pain share overlapping sensory pathways.
Hiroai Okutani +2 more
wiley +1 more source
Learning Protein Dynamics with Metastable Switching Systems [PDF]
arXiv, 2016 We introduce a machine learning approach for extracting fine-grained representations of protein evolution from molecular dynamics datasets. Metastable switching linear dynamical systems extend standard switching models with a physically-inspired stability constraint.
arxiv
Effect of D-alanine methionine enkephalin amide on ion transport in rabbit ileum.
Journal of Clinical Investigation, 1980 The presence of enkephalins in the intestine and the use of opiates to treat diarrheal diseases suggests that enkephalins may affect intestinal ion transport.
J. Dobbins, L. Racusen, H. Binder
semanticscholar +1 more source
Prediction of Peptide Conformation by the Multicanonical Algorithm [PDF]
arXiv, 1993 We test the effectiveness of the multicanonical algorithm for the tertiary structure prediction of peptides and proteins. As a simple example we study Met-enkephalin. The lowest-energy conformation obtained agrees with that determined by other methods such as Monte Carlo simulated annealing.
arxiv