Results 151 to 160 of about 764,898 (194)

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
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Cysteine and methionine oxidation in thrombotic disorders

Current Opinion in Chemical Biology, 2023
Thrombosis is the leading cause of death in many diseased conditions. Oxidative stress is characteristic of these conditions. Yet, the mechanisms through which oxidants become prothrombotic are unclear. Recent evidence suggests protein cysteine and methionine oxidation as prothrombotic regulators.
Moua Yang, Brian C. Smith
openaire   +2 more sources

Methionine oxidation and aging

Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 2005
It is well established that many amino acid residues of proteins are susceptible to oxidation by various forms of reactive oxygen species (ROS), and that oxidatively modified proteins accumulate during aging, oxidative stress, and in a number of age-related diseases.
Earl R, Stadtman, Holly, Van Remmen, Arlan, Richardson, Nancy B, Wehr, Rodney L, Levine   +4 more
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The Quantitative Oxidation of Methionine to Methionine Sulfoxide by Peroxynitrite

Archives of Biochemistry and Biophysics, 2000
Both peroxynitrous acid and peroxynitrite react with methionine, k(acid) = (1.7 +/- 0.1) x 10(3) M(-1) s(-1) and k(anion) = 8.6 +/- 0.2 M(-1) s(-1), respectively, and with N-acetylmethionine k(acid) = (2.8 +/- 0.1) x 10(3) M(-1) s(-1) and k(anion) = 10.0 +/- 0.1 M(-1) s(-1), respectively, to form sulfoxides.
Perrin D, Koppenol WH
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Periodate oxidation of methionine in proteins

Analytical Biochemistry, 1982
Abstract Treatment of free methionine with an equimolar amount of periodate gave nearly quantitative formation of the sulfoxide; treatment of free methionine sulfoxide with equimolar periodate gave nearly equal amounts of the original sulfoxide and the sulfone.
R B, Yamasaki, D T, Osuga, R E, Feeney
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Identification of Oxidized Methionine in Peptides

Rapid Communications in Mass Spectrometry, 1996
The positive- and negative-ion collision-induced dissociation spectra of peptides containing methionine, methionine sulphoxide and methionine sulphone have been studied. Characteristic fragmentations were identified and evaluated as possible indicators for the presence of oxidized methionine residues in peptides.
F M, Lagerwerf, M, van de Weert, W, Heerma, J, Haverkamp   +3 more
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Oxidation of methionine residues in lutropin

Canadian Journal of Biochemistry, 1980
Bovine lutropin and its subunits were submitted to oxidation by sodium periodate or chloramine T. Methionine residues were easily oxidized but partial destruction of fucose was observed. After oxidation treatment most of the lutropin exhibits the same elution volume in gel filtration as the native hormone.
P, De la Llosa, A, El Abed, M, Roy
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Spontaneous Oxidation of Methionine: Effect on the Quantification of Plasma Methionine Levels

Analytical Biochemistry, 1997
Plasma methionine (Met), methionine sulfoxide (MSO), and total Met concentrations were determined by reversed-phase chromatography and fluorescence detection after automated precolumn derivatization with an o-phthalic aldehyde mercaptoethanol reagent.
H C, Potgieter, J B, Ubbink, S, Bissbort, M J, Bester, J H, Spies, W J, Vermaak   +5 more
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Role of Individual Methionines in the Fibrillation of Methionine-Oxidized α-Synuclein

Biochemistry, 2004
The aggregation of normally soluble alpha-synuclein in the dopaminergic neurons of the substantia nigra is a crucial step in the pathogenesis of Parkinson's disease. Oxidative stress is believed to be a contributing factor in this disorder. We have previously established that oxidation of all four methionine residues in alpha-synuclein (to the ...
Hokenson, Mark J., Uversky, Vladimir N., Goers, John, Yamin, Ghiam, Munishkina, Larissa A., Fink, Anthony L.   +5 more
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Selective oxidation of methionine residues in proteins

Biochemistry, 1975
Methionine residues in peptides and proteins were oxidized to methionine sulfoxides by mild oxidizing reagents such as chloramine-T and N-chlorosuccinimide at neutral and slightly alkaline pH. With chloramine-T cysteine was also oxidized to cystine but no other amino acid was modified; with N-chlorosuccinimide tryptophans were oxidized as well.
Y, Shechter, Y, Burstein, A, Patchornik
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