Results 111 to 120 of about 1,892,546 (315)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

CVTresh: R Package for Level-Dependent Cross-Validation Thresholding [PDF]

The core of the wavelet approach to nonparametric regression is thresholding of wavelet coefficients. This paper reviews a cross-validation method for the selection of the thresholding value in wavelet shrinkage of Oh, Kim, and Lee (2006), and introduces
Hee-Seok Oh, Donghoh Kim
core   +1 more source

Development and validation of a normal phase HPLC method for separation of anacardic acid isomers in cashew nut shell liquid [PDF]

, 2013
A simple normal phase HPLC method was developed and validated for the separation and determination of anacardic acid isomers present in cashew nut shell liquid. A Chiralpack, IA Chiral column (250 mm x 4.6 mm, packed with 5 microns) is used as stationary
Mantelingu, K., Praveen Kumar, S. N., Bhadregowda, D. G., Rangappa, K. S., Vathsala Deepu, C.   +4 more
core  

Quantification of Fecal Short Chain Fatty Acids by Liquid Chromatography Tandem Mass Spectrometry—Investigation of Pre-Analytic Stability

Biomolecules, 2019
Short chain fatty acids (SCFAs) are generated by the degradation and fermentation of complex carbohydrates, (i.e., dietary fiber) by the gut microbiota relevant for microbe–host communication.
Gerhard Liebisch, Josef Ecker, Sebastian Roth, Sabine Schweizer, Veronika Öttl, Hans-Frieder Schött, Hongsup Yoon, Dirk Haller, Ernst Holler, Ralph Burkhardt, Silke Matysik   +10 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Analytical Study of Pharmaceutical Substances: Method Development and Validation Study: Few Case Studies [PDF]

, 2011
Not ...
Kaila, Harshad O.
core  

Pre-validation methods for developing a patient reported outcome instrument [PDF]

, 2011
Background: Measures that reflect patients' assessment of their health are of increasing importance as outcome measures in randomised controlled trials.
Ramsay, Craig R, Burr, JM, Hamzah, J. C., Burr Jennifer M, Susan E Campbell, Francis, JJ, Prior, M., Che Hamzah, Jemaima, Azuara-Blanco, Augusto; id_orcid, Campbell, S. E., Castillo, MM, Prior Maria E, Maria E Prior, Castillo, Mayret M, Hamzah, Jemaima Che, Francis, Jillian J., Ramsay, CR, Prior, Maria E, Hamzah, JC, Campbell Susan E, Campbell, SE, Francis, Jillian J, Jemaima Che Hamzah, Prior, Maria E., Azuara-Blanco, A., Mayret M Castillo, Ramsay, Craig R., Ramsay, C. R., Castillo Mayret M, Francis, J., Castillo, M, Castillo, Mayret M., Burr, J. M., Prior, ME, Campbell, Susan E, Jillian J Francis, Craig R Ramsay, Burr, Jennifer M., Jennifer M Burr, Azuara-Blanco, A, Azuara-Blanco, Augusto, Burr, Jennifer M, Campbell, Susan E., Francis Jillian J, Hamzah Jemaima, Ramsay Craig R, Augusto Azuara-Blanco, Azuara-Blanco Augusto   +47 more
core   +1 more source

Qualitative and quantitative evaluation of melittin in honeybee venom and drug products containing honeybee venom

Journal of Apicultural Science, 2013
A reverse-phase high-performance liquid chromatographic (RP -HPLC ) method was developed and validated for the analysis of honeybee venom samples and drug products containing honeybee venom.
Haghi Ghasem, Hatami Alireza, Mehran Mehdi   +2 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Experimental methods of evaluating measurement uncertainty resulting from sample collection and preparation for analysis in chemical laboratories / Niepewność pomiaru wynikająca z poboru i przygotowania próbek do badań w laboratorium chemicznym oszacowana metodą doświadczalną

Environmental Protection and Natural Resources, 2014
W artykule przedstawiono metodę doświadczalną szacowania niepewności wyniku pomiaru związanej z poborem i przygotowaniem próbek do badań w laboratorium chemicznym.
Giercuszkiewicz-Bajtlik Mieczysława, Gworek Barbara   +1 more
doaj   +1 more source