Results 101 to 110 of about 1,892,546 (315)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
A rapid spectrophotometric method for determination of thiobarbituric acid reactive substances in rainbow trout feed [PDF]
Food and Feed Research, 2020 Oxidative changes in fish feed during storage are a major problem in aquaculture nutrition. The current study aims to present fast and simple spectrometric method to measure thiobarbituric acid reactive substances (TBARS) in the commercial rainbow trout ...
Rakita Slađana M. +6 more
doaj
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
A new adaptive response surface method for reliability analysis [PDF]
, 2013 Response surface method is a convenient tool to assess reliability for a wide range of structural mechanical problems. More specifically, adaptive schemes which consist in iteratively refine the experimental design close to the limit state have received ...
Salaün, Michel +2 more
core +1 more source
On the Empirical Validity of the Bayesian Method
Journal of the Royal Statistical Society Series B: Statistical Methodology, 1993 SUMMARY The ideas in Kolmogorov's programme for algorithmic substantiation of applications of probability make it possible to define a measure of disagreement between the probability distribution representing the attitude of a coherent individual towards a random experiment and the outcome of the experiment.
Vovk, V. G., V'yugin, V. V.
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Molecules, 2019 The intracellular drug concentration is needed for determination of target exposure at the site of action regarding its pharmacological action and adverse effects.
Tarapong Srisongkram +1 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Towards the validation of adaptive educational hypermedia using CAVIAr [PDF]
, 2008 Migrating from static courseware to Adaptive Educational Hypermedia presents significant risk to the course creator. In this paper we alleviate some of this risk by outlining how the CAVIAr courseware validation framework can be used to validate some ...
Mark Melia +5 more
core +1 more source