Results 31 to 40 of about 3,918,910 (289)

Research on detection methods of related substances and degradation products of the antitumor drug selpercatinib

Frontiers in Chemistry
BackgroundSelpercatinib, a selective RET kinase inhibitor, is approved for treating various cancers with RET gene mutations such as RET-rearranged thyroid cancer and non-small cell lung cancer.
Jingjing Xiang, Liangliang Cai, Qin Wang, Yonghong Zhu, Yong Han   +4 more
doaj   +1 more source

Complete intra-laboratory validation of a LAL assay for bacterial endotoxin determination in EBV-specific cytotoxic T lymphocytes

Molecular Therapy: Methods & Clinical Development, 2021
Endotoxin content is a critical factor that affects the safety of biological pharmaceutical products. International pharmacopoeias describe several reference methods to determine endotoxin levels in advanced therapy medicinal product (ATMP) preparations.
Salvatore Pasqua, Maria Concetta Niotta, Giuseppina Di Martino, Davide Sottile, Bruno Douradinha, Monica Miele, Francesca Timoneri, Mariangela Di Bella, Nicola Cuscino, Chiara Di Bartolo, Pier Giulio Conaldi, Danilo D’Apolito   +11 more
doaj   +1 more source

Development and validation of a PMA-qPCR method for accurate quantification of viable Lacticaseibacillus paracasei in probiotics

Frontiers in Microbiology
The effectiveness of probiotic products hinges on the viability and precise quantification of probiotic strains. This study addresses this crucial requirement by developing and validating a precise propidium monoazide combination with quantitative ...
Lizheng Guo, Xiaolei Ze, Yingxin Jiao, Chengyu Song, Xi Zhao, Zhiquan Song, Shuaicheng Mu, Yiru Liu, Yuanyuan Ge, Yu Jing, Su Yao   +10 more
doaj   +1 more source

Toolbox for the Extraction and Quantification of Ochratoxin A and Ochratoxin Alpha Applicable for Different Pig and Poultry Matrices

Toxins, 2022
Ochratoxin A (OTA) is one of the major mycotoxins causing severe effects on the health of humans and animals. Ochratoxin alpha (OTα) is a metabolite of OTA, which is produced through microbial or enzymatic hydrolysis, and one of the preferred routes of ...
Barbara Streit, Tibor Czabany, Georg Weingart, Martina Marchetti-Deschmann, Shreenath Prasad   +4 more
doaj   +1 more source

Leveraging Semantic Web Service Descriptions for Validation by Automated Functional Testing [PDF]

, 2009
Recent years have seen the utilisation of Semantic Web Service descriptions for automating a wide range of service-related activities, with a primary focus on service discovery, composition, execution and mediation.
A. Bertolino, C. Keum, D. Dranidis, D. Kourtesis, D. Martin, D. Martin, F. Ipate, G.D. Plotkin, M. Holcombe, R. Heckel, S. Eilenberg, T.S. Chow   +11 more
core   +2 more sources

Face Validation Method Alternatives for Shiphandling Fuzzy Logic Difficulty Model [PDF]

, 2014
The development of shiphandling difficulty model for ferry is based on the empirical experience through the Master of Ro-Ro ferries. The SHDMF is consisted from two parts which are the Analytic Hierarchy Process (AHP) and Fuzzy Inference System.
Benabdelhafid, A. (Abdellatif), Priadi, A. A. (Antoni), Tjahjono, T. (Tri)   +2 more
core  

Carcinomas and Carcinoid Tumors of the Lungs and Bronchi in Children and Adolescents: The EXPeRT Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Primary lung carcinomas and bronchial carcinoid tumors (BC) are very rare malignancies in childhood. While typical BC and mucoepidermoid carcinomas are mostly low‐grade, localized tumors with a more favorable prognosis than in adults, necessitating avoidance of overtreatment, adenocarcinomas of the lung are often diagnosed at advanced disease ...
Michael Abele, Calogero Virgone, Michaela Kuhlen, Sabine Irtan, Yves Reguerre, Malgorzata Krawczyk, Ewa Bien, Tal Ben‐Ami, Maja Cesen, Ricardo Lopez‐Almaraz, Andrea Ferrari, Gianni Bisogno, Dominik T. Schneider, Abbas Agaimy, Constantin Lapa, Hubert Ducou le Pointe, Rainer Claus, Catherine Daniel, Ines B. Brecht, Daniel Orbach   +19 more
wiley   +1 more source

Optimization, Validation, and Application of Cleanup-Coupled Liquid Chromatography–Tandem Mass Spectrometry for the Simultaneous Analyses of 35 Mycotoxins and Their Derivatives in Cereals

Foods
Mycotoxins occur singly or as co-contaminants and are primarily present in carbohydrate-rich foods such as cereals and cereal-based products. To effectively monitor mycotoxin co-contamination in cereals and cereal-based products, the simultaneous ...
Dan-Bi Kim, Miso Nam, Yong-Suk Kim, Min-Sun Kim   +3 more
doaj   +1 more source

Fast Cross-Validation via Sequential Testing [PDF]

, 2015
With the increasing size of today's data sets, finding the right parameter configuration in model selection via cross-validation can be an extremely time-consuming task.
Braun, Mikio, Krueger, Tammo, Panknin, Danny   +2 more
core  

Parent Quality of Life at Two Years Following Their Child's Completion of Acute Lymphoblastic Leukemia Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Parents of children treated for acute lymphoblastic leukemia (ALL) often experience significant caregiver burden and disruption to their well‐being. While parent quality of life (QoL) during treatment is well characterized, little is known about outcomes during early survivorship.
Sara Dal Pra, Maria McCarthy, Michael Takagi, Cinzia De Luca   +3 more
wiley   +1 more source