Results 181 to 190 of about 8,171,446 (309)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Social care division/quality improvement division QI programme newsletter April 2017

, 2017
Programme newsletter for the social care division/quality improvement division quality improvement ...
National Quality Improvement Team
core  

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Methodological quality of nursing guidelines in China: an AGREE II and RIGHT appraisal (2023-2024). [PDF]

BMC Nurs
Xuan M, Wang D, Fan T, Zhao W, Liang W, Liu N, Li H, Hou R, Ming X.   +8 more
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Tenmile Lakes watershed water quality management plan (WQMP)

, 2007
prepared by Oregon Department of Environmental Quality ; submissions by Oregon Department of Forestry, Oregon Department of Agriculture, Oregon Department of Transportation, Tenmile Lakes Basin Partnership.Title from PDF cover (viewed on March 21, 2023 ...

core  

Systematic reviews in PRP-augmented meniscal repair have limited methodological quality: A systematic overview. [PDF]

J Exp Orthop
Hantouly AT, Agostinone P, Romandini I, Sandon A, Zannoni F, Muthu S, Alkhelaifi K, Papakostas E.   +7 more
europepmc   +1 more source

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

A systematic review of the methodological quality of randomised trials in IBD surgery. [PDF]

Colorectal Dis
Aimar K, Gaur A, Peirson M, Walshaw J, Pinkney TD, Lee MJ.   +5 more
europepmc   +1 more source

Evaluation of protein quality: Methodological Considerations [PDF]

Proceedings of the Nutrition Society, 1982
openaire   +2 more sources