Results 181 to 190 of about 578,219 (312)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Transparency and Methodological Quality of Clinical Practice Guidelines in Palliative Care. Scoping Review. [PDF]

J Eval Clin Pract
Torres-Cuellar JC, Pérez-Muñoz DA, Florez ID, Ahmedzai SH, de Vries E, Calvache JA.   +5 more
europepmc   +1 more source

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Patient-reported outcomes in randomized controlled trials of spinal disorders: a methodological quality assessment and recommendations for future research. [PDF]

EFORT Open Rev
He W, Liu R, Ma J, Hou W, Li Z, Du L.
europepmc   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Methodological quality of cardiac CT and MRI radiomics studies assessed using METRICS and RQS by human readers and ChatGPT 5.1 Thinking. [PDF]

Eur Radiol Exp
Garello LF, Giannini V, Gatti M, Defeudis A, Cafaro D, Nicoletti G, Culasso NC, Faletti R, Veltri A, Cuocolo R, Balbi M.   +10 more
europepmc   +1 more source

Evaluation of protein quality: Methodological Considerations [PDF]

Proceedings of the Nutrition Society, 1982
openaire   +2 more sources

Methodological Guidance for a Quality Review Article [PDF]

The Gerontologist, 2019
Patricia C, Heyn, Suzanne, Meeks, Rachel, Pruchno   +2 more
openaire   +2 more sources

Pathways and pitfalls: a qualitative study of student experiences in biomedical science education

FEBS Open Bio, EarlyView.
Biomedical science students from underrepresented backgrounds face barriers including financial strain, disrupted laboratory access and cultural exclusion. Peer networks provide vital support when institutional systems are difficult to navigate. To create inclusive learning environments and achieve academic success, educators should blend active, hands‐
Olivia J. Russell, Cassy Ross, Panagiota S. Filippou, Bruno Silvester Lopes, Dominic Gilchrist, Paul Dean, Kamar Ameen‐Ali, Tora K. Smulders‐Srinivasan, Ahmad A. Khundakar   +8 more
wiley   +1 more source

Twenty Years of Dispersive Liquid-Liquid Microextraction: An Umbrella Review of Methodological Quality, Thematic Evolution, and Roadmap for Evidence Integration in Analytical Chemistry. [PDF]

Molecules
Faraji H, Conde Díaz A, Santana Mayor Á, Socas-Rodríguez B, Herrera Herrera AV.   +4 more
europepmc   +1 more source