Results 41 to 50 of about 547,138 (218)

Immune imbalance in the pre-ovulatory follicular microenvironment of overweight and obese women during IVF

Journal of Ovarian Research
Background Overweight and obesity can induce an inflammatory milieu in the oocyte microenvironment and are closely associated with reduced assisted reproductive outcomes.
Yang Liu, Yiran Zhao, Chengliang Zhou, Hong Zhu, Jiexue Pan, Jing Fu, Hefeng Huang, Hui Lin, Li Jin   +8 more
doaj   +1 more source

Rapid deployment valve system shortens operative times for aortic valve replacement through right anterior minithoracotomy

Journal of Cardiothoracic Surgery, 2017
Background There is growing evidence from the literature that right anterior minithoracotomy aortic valve replacement (RAT-AVR) improves clinical outcome.
Constanze Bening, Khaled Hamouda, Mehmet Oezkur, Christoph Schimmer, Ina Schade, Armin Gorski, Ivan Aleksic, Rainer Leyh   +7 more
doaj   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Development of detection method for the generating state of maximun friction force on CVT belt

Nihon Kikai Gakkai ronbunshu, 2019
Vehicles with a metal belt-type continuously variable transmission(CVT) that can run under optimal engine fuel consumption conditions have been popular. However, the CVT unit itself can improve in terms of the efficiency. This is possible as the clamping
Hiroyuki YAMAGUCHI, Hiroyuki NISHIZAWA, Masataka OSAWA, Keisuke NINOMIYA   +3 more
doaj   +1 more source

Boosting of fruit choices using machine learning-based pomological recommendation system

SN Applied Sciences, 2023
Pomology, also known as fruticulture, is a significant contributor to the economies of many nations worldwide. While vertical farming methods are not well-suited for fruit cultivation, substrate-based cultivation is commonly practiced.
Monica Dutta, Deepali Gupta, Sapna Juneja, Asadullah Shah, Asadullah Shaikh, Varun Shukla, Mukesh Kumar   +6 more
doaj   +1 more source

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Crack inhibition and crystallographic texture control in an additively manufactured IN738LC Ni-based superalloy

Journal of Materials Research and Technology
The additive manufacturing of directionally solidified Ni-based superalloys remains a significant challenge due to the formation of stray equiaxed grains and their high susceptibility to cracking, particularly for high-volume γ´-type Ni-based superalloys.
Fangxian Zhang, Liping Zhou, Xinliang Xie, Zhenbo Zhang, Qi Chao, Guohua Fan   +5 more
doaj   +1 more source

Dynamics of variable-viscosity nanofluid flow with heat transfer in a flexible vertical tube under propagating waves

Results in Physics, 2017
Background and objectives: The present investigation addresses nanofluid flow and heat transfer in a vertical tube with temperature-dependent viscosity. A Tiwari-Das type formulation is employed for the nanofluid with a viscosity modification.
A. Bintul Huda, Noreen Sher Akbar, O. Anwar Beg, M. Yaqub Khan   +3 more
doaj   +1 more source