Results 11 to 20 of about 3,512 (157)

Ni/Cu Dual-Catalyzed Propargylation for the Stereodivergent Synthesis of Methohexital. [PDF]

Adv Sci (Weinh)
A highly efficient Ni/Cu dual‐catalyzed stereodivergent propargylation reaction is successfully devised, offering a novel approach for the asymmetric synthesis with significant diastereo‐ and enantioselectivities (up to >20:1 dr, >99% ee). This efficient process offers a novel pathway for the stereodivergent total synthesis of Methohexital.
Chang X, Zhang J, Cheng X, Lv X, Guo C.
europepmc   +2 more sources

Inactivation of the Phosphatase Activity of Soluble Epoxide Hydrolase Modulates SIRT3 and Attenuates Experimental Pulmonary Hypertension. [PDF]

Compr Physiol
Genetic inactivation of the phosphatase activity of soluble epoxide hydrolase prevents the development of pulmonary hypertension in rats, partly through upregulation of SIRT3 expression and decreased cell proliferation and apoptosis‐related proteins. Targeting sEH‐P emerges as a promising therapeutic strategy for pulmonary hypertension.
Leuillier M, Chelgham M, Messaoudi H, Tu L, Ménoret S, Thuillet R, Groussard D, Lillich FF, Ottaviani M, Nicol L, Mulder P, Humbert M, Richard V, Anegon I, Morisseau C, Proschak E, Guignabert C, Bellien J.   +17 more
europepmc   +2 more sources

The human photosensitive epilepsy model for clinical proof-of-principle trials of novel antiseizure medications: 2. Analysis of drug trials and predictive value of the model. [PDF]

Epilepsia
Abstract Clinical development of novel antiseizure medications (ASMs) would benefit from an early proof of principle (POP) model. The photosensitivity model, which uses the photoparoxysmal electroencephalographic response (PPR) as a surrogate of seizures, is currently the only human model that allows POP trials of investigational compounds after a ...
Löscher W, Trenité DK.
europepmc   +2 more sources

Direct Current Auditory Evoked Potentials During Wakefulness, Anesthesia, and Emergence from Anesthesia [PDF]

, 2001
Direct current auditory evoked potentials (DC-AEPs) are a sensitive indicator of depth of anesthesia in ani-mals. However, they have never been investigated in humans. To assess the potential usefulness of DC-AEPs as an indicator of anesthesia in humans,
Bauer, Herbert, Fitzgerald, Robert, Lamm, Claus, Oczenski, Wolfgang, Stimpfl, Thomas, Vycudilik, Walter   +5 more
core   +1 more source

Repurposing ketamine to treat cocaine use disorder: integration of artificial intelligence‐based prediction, expert evaluation, clinical corroboration and mechanism of action analyses

Addiction, Volume 118, Issue 7, Page 1307-1319, July 2023., 2023
Abstract Background and aims Cocaine use disorder (CUD) is a significant public health issue for which there is no Food and Drug Administration (FDA) approved medication. Drug repurposing looks for new cost‐effective uses of approved drugs. This study presents an integrated strategy to identify repurposed FDA‐approved drugs for CUD treatment.
Zhenxiang Gao, T. John Winhusen, Maria Gorenflo, Udi E. Ghitza, Pamela B. Davis, David C. Kaelber, Rong Xu   +6 more
wiley   +1 more source

A systematic review of modified electroconvulsive therapy (ECT) to treat delirium

Acta Psychiatrica Scandinavica, Volume 147, Issue 5, Page 403-419, May 2023., 2023
Abstract Background Delirium is costly for patients, carers, and healthcare systems. In addition, non‐pharmacological and pharmacological management of delirium is challenging. Electroconvulsive therapy (ECT) has been proposed and used as an anecdotal treatment of delirium in clinical practice.
Katie Lupke, Nicola Warren, Andrew Teodorczuk, Sarah Steele, Uday Kolur, Anne Wand, Gail Robinson, Stephen Parker   +7 more
wiley   +1 more source

Recuperação pós-eletroconvulsoterapia: comparação entre propofol, etomidato e tiopental [PDF]

, 2008
OBJECTIVES: To compare post anesthetic time for patient recovery after electroconvulsive therapy, as measured by the post anesthetic Recovery Score of Aldrete and Kroulik, using three different types of hypnotic drugs (propofol, etomidate and thiopental).
BELEGARDE, Iara M T, BUENO, Celso R, FREGNI, Felipe, ROSA, Marina O, ROSA, Moacyr A   +4 more
core   +1 more source

Sedation in Children: Current Concepts [PDF]

, 1998
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/90049/1/j.1875-9114.1998.tb03900.x ...
Bhatt‐mehta, Varsha, Rosen, David A.
core   +1 more source

Diaspirin cross-linked hemoglobin fails to improve left ventricular diastolic function after fluid resuscitation from hemorrhagic shock [PDF]

, 2001
In severe hemorrhagic shock, left ventricular (LV) diastolic dysfunction is an early sign of cardiac failure due to compromised myocardial oxygenation.
Habler, Oliver, Kemming, Gregor, Kleen, Martin, Meisner, F., Pape, Andreas   +4 more
core   +1 more source

Effect of Intravenous Phenobarbital on Left Ventricular Myocardial Contractility Determined by Echocardiography in Children [PDF]

, 2019
Introduction. Animal studies and rare human studies have suggesteda negative effect of barbiturates on cardiac function. Althoughintravenous (IV) phenobarbital is used routinely in children in theclinical setting, studies in children are lacking.
Amre, Devendra, Balaguru, Duraisamy, Doshi, Arpan R., Erikson, Christain, Malhotra, Monesha Gupta   +4 more
core   +2 more sources