Results 181 to 190 of about 163,856 (309)

SYNTHESIS OF METHOTREXATE POLYGLUTAMATES IN CULTURED HUMAN CELLS [PDF]

, 1977
David S. Rosenblatt, V H Whitehead, Matthias Dupont, MJ Vuchich, N Vera, C. R. Scriver   +5 more
openalex   +1 more source

Recent Advances in Isatin–Thiazole Hybrids: Synthesis, Structural Design, and Biological Application

Chemistry &Biodiversity, EarlyView.
ABSTRACT Isatin–thiazole hybrids are considered privileged chemical scaffolds due to their broad spectrum of pharmacological properties, making them attractive candidates for drug development. As a result, isatin–thiazole derivatives have emerged as a prominent class of hybrid heterocycles and have been the focus of extensive research in recent years ...
Isadora M. G. Andrade, Edson de O. Lima Filho, Caio F. Valadão, Luana da S. M. Forezi, Fernando de C. da Silva   +4 more
wiley   +1 more source

Erythrocyte Methotrexate-Polyglutamate Concentrations in Pediatric Inflammatory Bowel Disease. [PDF]

Inflamm Bowel Dis
Vermeer E, Struys EA, Lin M, van Limbergen JE, de Boer NKH, Bulatović-Ćalasan M, de Meij TGJ, de Jonge R.   +7 more
europepmc   +1 more source

Comparison of 5-fluorouracil with 5-fluorouracil, cyclophosphamide, and methotrexate in metastatic colorectal carcinoma [PDF]

, 1975
Frederick Richards, Thomas Pajak, M. Robert Cooper, Charles L. Spurr   +3 more
openalex   +1 more source

Nanogel‐Mediated Immunotherapy to Tackle Cancer and Inflammatory Diseases

ChemistryEurope, EarlyView.
Nanogels formed through self‐assembly, microemulsion, or precipitation polymerization method enable precise delivery of immunotherapeutic factors and immune cell targeting, thus effectively modulating immune responses. This review highlights recent advances in stimuli‐responsive nanogel design, underlying mechanisms, and their potentials to tackle ...
Ziwen Zhang, Jinxia Wang, Guang‐Zhi Jin, István Bányai, Dzmitry Shcharbin, Ivan Stoikov, Mingwu Shen, Xiangyang Shi   +7 more
wiley   +1 more source

Key Drivers and Mitigation Strategies of Oncology Drug Shortages 2023 to 2025. [PDF]

Cancer J
Socal MP, Acha J, Yang CY, Sun Y, Dada M, Dai T, Anderson G, Ballreich J.   +7 more
europepmc   +1 more source

Conjugation of methotrexate to poly(L-lysine) increases drug transport and overcomes drug resistance in cultured cells

, 1978
Hugues J.‐P. Ryser, Wei‐Chiang Shen
openalex   +1 more source

Evolving Real‐World Data and Evidence Use for New Drugs and Regenerative Medical Products Approvals in Japan—An Analysis of the 6‐Year Trend

Clinical Pharmacology &Therapeutics, EarlyView.
Several regulatory initiatives have been made to clarify the acceptability and requirements of real‐world data and real‐world evidence (RWD/E) for the benefit/risk assessment of new medical products in Japan. The objectives of this review were to characterize the use of RWD/E in regulatory applications of new medical products and to describe the ...
Suguru Okami, Kako Shimotsumagari, Yasunari Sadatsuki   +2 more
wiley   +1 more source

Factors influencing the choice of non-biologic versus biologic immunosuppressive therapy in systemic lupus erythematosus. [PDF]

Sci Rep
Bortoluzzi A, Marangoni A, Silvagni E, Rozza D, Bartoloni E, Blagojevic J, Pallavicini FB, Bozzolo E, Canti V, Cavagna L, Cavazzana I, Coladonato L, Conigliaro P, Crisafulli F, Ditto MC, Emmi G, Ferrigno S, Franceschini F, Frassi M, Garaffoni C, Gerosa M, Govoni M, Guiducci S, Iaccarino L, Manfredi A, Mancuso S, Mosca M, Naclerio C, Orefice V, Parisi S, Pazzola G, Pettiti G, Prevete I, Ramirez GA, Scirocco C, Spinelli FR, Zen M, Carrara G, Scirè CA, Conti F, Doria A, Sebastiani GD.   +41 more
europepmc   +1 more source

Regulation of folate reductase synthesis in sensitive and methotrexate-resistant sarcoma 180 cells. In vitro translation and characterization of folate reductase mRNA.

, 1976
Rodney E. Kellems, F W Alt, Robert Schimke   +2 more
openalex   +1 more source