Results 191 to 200 of about 166,279 (314)

Precision Chemistry for Protein Lysine Modification

Chemistry – A European Journal, EarlyView.
Selective modification of lysine residues is challenging due to their similar intrinsic reactivity. Inspired by enzymatic recognition, ligand‐guided electrophiles enable site‐selective labeling and functionalization, while ligand‐guided catalyses achieve regioselective installation of bio‐relevant post‐translational modifications.
Mayu Onoda, Motomu Kanai
wiley   +1 more source

Atypical Location of Noninfectious Esophageal Ulceration in a Chronically Immunosuppressed Patient. [PDF]

ACG Case Rep J
Rivera Hernández TN, Sundi SH, Singh R, Habashi S.   +3 more
europepmc   +1 more source

Methotrexate pharmacogenomics [PDF]

Annals of the Rheumatic Diseases, 2006
openaire   +2 more sources

The Visual Predictive Check and Real‐World Data

Clinical Pharmacology &Therapeutics, EarlyView.
The visual predictive check (VPC) is a standard tool for assessing pharmacometric model suitability, producing visualizations that compare observed data with simulated data such that both model structure and model variability terms can be assessed. However, real‐world data commonly reflect clinical decision‐making that adapts therapy in response to ...
Jasmine H. Hughes, Martin Bergstrand, Ron J. Keizer   +2 more
wiley   +1 more source

Clinical Model‐Informed Precision Dosing Consult Service for Accelerating Personalized Medication in Pediatric Patients

Clinical Pharmacology &Therapeutics, EarlyView.
Traditional dosing strategies often rely on a “one‐size‐fits‐all” paradigm, assuming an “average” patient with typical demographic and pharmacological characteristics. In reality, this often overlooks existing between‐patient variability and can lead to suboptimal drug exposure or toxicity. This issue is especially pronounced in pediatric patients, who
Zachary L. Taylor, Takanobu Nadai, Kei Irie, Wen Rui Tan, Sanjana Parikh, Anhar Hosawi, Matthijs W. van Hoogdalem, Ronaldo Morales Junior, Sonya Tang Girdwood, Abbie D. Leino, Kana Mizuno, Alexander A. Vinks, Tomoyuki Mizuno   +12 more
wiley   +1 more source

Efficacy and Safety of Adalimumab as Monotherapy Versus Adalimumab With Methotrexate for Psoriasis: A Systematic Review. [PDF]

Cureus
Alanazi AF, Almahdi MA, Alqurashi SO, Alassaf S, Almohanna A, Alayed ST, Alshehri M, Alsubaie KS, Hakami S.   +8 more
europepmc   +1 more source

Novel Organelle‐Based Intracellular Immunity With Mechanistic and Therapeutic Implications

Barrier Immunity, EarlyView.
A conceptual framework illustrating how PAMPs/DAMPs initiate barrier, innate, adaptive, and intracellular immune responses, with organelle‐based intracellular immunity serving as a central integrator linking metabolism, inflammatory signaling, and therapeutic interventions to restore immune homeostasis.
Keman Xu, Shih‐Yu Hung, Fatma Saaoud, Ying Shao, Yifan Lu, Juanjuan Liu, Bo Yuan, Haiyan Xiang, Hong Wang, Xiaofeng Yang   +9 more
wiley   +1 more source

When Methotrexate Is Not Enough: Hysteroscopic Management of an Angular Pregnancy With Discordant Beta-Human Chorionic Gonadotropin (b-hCG) and Ultrasound Findings. [PDF]

Cureus
Toscano FP, Gargano V, Cipullo L, Gallo R, Del Papato R, Laurelli G.   +5 more
europepmc   +1 more source

Photothermal bubble: Dynamics, manipulation, and applications

Droplet, EarlyView.
As a versatile platform for bubble manipulation, photothermal techniques empower diverse operations: planar translation by scanning the laser spot, sustained periodic bouncing from competing thermal and hydrodynamic flows, and even guided 3D trajectories achieved by tailoring the heating configuration.
Man Hu, Feng Wang, Daosheng Deng
wiley   +1 more source

The synergistic ototoxicity of adalimumab combined with methotrexate in the treatment of ankylosing spondylitis. [PDF]

Front Neurol
Wei H, Xu C.
europepmc   +1 more source