Abstract Objectives Acute severe colitis (ASC) is a frequent and severe complication of ulcerative colitis (UC) with a high risk of colectomy. Effects of immunosuppressants and anti–tumor necrosis factor (anti‐TNF) agents on the risk of colectomy remain debated. We wished to study the evolution of French pediatric‐onset UC patients after ASC.
Manon Cochet +18 more
wiley +1 more source
Correction: Pourroy et al. High-Dose Methotrexate at All Ages: Safety, Efficacy, and Outcomes from the HDMTX European Registry. <i>Cancers</i> 2026, <i>18</i>, 124. [PDF]
Pourroy B +22 more
europepmc +1 more source
A case report of Peutz–Jeghers syndrome in a child with Crohn's disease
Abstract Peutz–Jeghers syndrome (PJS) is a rare genetic disorder characterized by hamartomatous polyps and mucocutaneous hyperpigmented freckles, whereas Crohn's disease (CD) is a condition characterized by chronic intestinal inflammation. Here, we present a rare case report of an 11‐year‐old male who presented with both CD and PJS.
Hasala Rannulu +5 more
wiley +1 more source
Surgical Reconstruction in Pyoderma Gangrenosum, a Retrospective Study of Five Patients
ABSTRACT Pyoderma Gangrenosum (PG) is a neutrophilic dermatosis characterized by chronic painful ulcerations most commonly on the lower extremities. Current treatment options for PG are largely nonsurgical and include the use of systemic and topical immunomodulators and wound care.
Max E. Oscherwitz +8 more
wiley +1 more source
Low-Dose Methotrexate and Bone Health: Pathophysiological and Clinical Perspectives. [PDF]
Sokhan A +4 more
europepmc +1 more source
Effect of Systemic Immunomodulators on Incidence of Alopecia Areata: A Retrospective Cohort Study
ABSTRACT Background Alopecia areata (AA) is a chronic autoimmune hair loss disorder. Patients with primary autoimmune diseases commonly use systemic immunomodulators to manage disease and have an increased risk of developing AA. Systemic immunomodulators have diverse immunologic effects, but their impact on AA risk is not well understood. Objectives We
Angela Rose Liu +2 more
wiley +1 more source
Methotrexate and triamcinolone as a nonsurgical management for polymethyl methacrylate-induced granulomatous reaction: A case report. [PDF]
Silva RDC +4 more
europepmc +1 more source
ABSTRACT Immune‐checkpoint inhibitors (ICIs) have revolutionised melanoma treatment but can often cause severe and long‐standing cutaneous immune‐related adverse events (cirAEs). We report a case of refractory pembrolizumab‐induced pityriasis lichenoides (PL)‐like eruption successfully treated with dupilumab, leading to rapid and sustained remission ...
Evangelos Christou +2 more
wiley +1 more source
Utilization and Outcomes of High-Dose Methotrexate in CNS Lymphoma Patients on Hemodialysis: A Report of 2 Cases. [PDF]
Zafar A +6 more
europepmc +1 more source
Clinical Features and Therapeutic Outcomes in Pyoderma Gangrenosum: A Prospective Cohort Study
ABSTRACT Background Pyoderma gangrenosum (PG) is a rare neutrophilic dermatosis highly associated with systemic comorbidities. Accurate diagnosis and treatment remain challenging due to its rarity and clinical mimickers. Objectives To evaluate demographic, clinical features and treatment outcomes in patients referred with suspected PG at a tertiary ...
David Croitoru +13 more
wiley +1 more source

