Results 31 to 40 of about 369,868 (397)

Reply: Methotrexate neurotoxicity due to drug interactions: an inadequate folinic acid effect [PDF]

, 2017
No abstract ...
Baird, Susan F., Forster, Victoria J., Halsey, Christina, Mair, Shona, Skinner, Roderick, van Delft, Frederik W.   +5 more
core   +1 more source

Methotrexate and rheumatoid arthritis associated interstitial lung disease

European Respiratory Journal, 2020
Question addressed by the study Methotrexate (MTX) is a key anchor drug for rheumatoid arthritis (RA) management. Fibrotic interstitial lung disease (ILD) is a common complication of RA.
P. Juge, Joyce S. Lee, J. Lau, Letícia Kawano-Dourado, J. Serrano, M. Sebastiani, G. Koduri, E. Matteson, K. Bonfiglioli, M. Sawamura, R. Kairalla, L. Cavagna, E. B. Cassione, A. Manfredi, M. Mejía, P. Rodríguez-Henríquez, M. González-Pérez, R. Falfán-Valencia, I. Buendía-Roldán, G. Pérez-Rubio, E. Ebstein, S. Gazal, S. Gazal, R. Borie, S. Ottaviani, C. Kannengiesser, B. Wallaert, Y. Uzunhan, H. Nunes, D. Valeyre, N. Saidenberg-Kermanac’h, M. Boissier, L. Wémeau-Stervinou, R. Flipo, S. Marchand-Adam, P. Richette, P. Richette, Y. Allanore, Y. Allanore, C. Dromer, M. Truchetet, C. Richez, T. Schaeverbeke, H. Lioté, G. Thabut, K. Deane, J. Solomon, T. Doyle, J. Ryu, I. Rosas, V. Holers, C. Boileau, M. Debray, R. Porcher, D. Schwartz, R. Vassallo, B. Crestani, P. Dieudé   +57 more
semanticscholar   +1 more source

Ethanolic Extract of Capparis decidua Fruit Ameliorates Methotrexate-Induced Hepatotoxicity by Activating Nrf2/HO-1 and PPARγ Mediated Pathways

, 2021
Introduction: Methotrexate, a folate antimetabolite, immunosuppressant and cytotoxic chemotherapeutic agents employed for malignant conditions. Continuous exposure of methotrexate produces adverse side effects especially liver toxicity.
Preetha Santhakumar, A. Roy, K. Mohanraj, Selvaraj Jayaraman, R. Durairaj   +4 more
semanticscholar   +1 more source

Hepatic methotrexate-associated lymphoproliferative disorders identified by multiple liver tumors: a case report and review of the literature

Journal of Medical Case Reports, 2019
Background Methotrexate, an immunosuppressant, is widely used as the standard therapeutic drug for rheumatoid arthritis. With the increasing frequency of use of methotrexate, adverse effects of methotrexate have been reported, one of which is known as ...
Ryohei Ono, Tomohiro Kumagae, Haruki Uojima, Shinichi Teshima, Madoka Kudo, Izumi Kitagawa, Masaki Yoshizawa   +6 more
doaj   +1 more source

The pharmacogenetics of methotrexate [PDF]

Rheumatology, 2007
Methotrexate (MTX) is a cornerstone of therapy for rheumatoid arthritis. However, it is not universally effective and up to one-third of patients fail to respond to treatment, either because of inefficacy or adverse events, although at present it is not possible to predict therapy response accurately.
S L, Hider, I N, Bruce, W, Thomson
openaire   +2 more sources

Efficacy and Safety of Upadacitinib Monotherapy in Methotrexate‐Naive Patients With Moderately‐to‐Severely Active Rheumatoid Arthritis (SELECT‐EARLY): A Multicenter, Multi‐Country, Randomized, Double‐Blind, Active Comparator–Controlled Trial

Arthritis & Rheumatology, 2020
The SELECT‐EARLY trial was undertaken to study the effect of upadacitinib, an oral, reversible Janus kinase 1–selective inhibitor, as monotherapy in patients with predominantly early rheumatoid arthritis who were naive for or had limited exposure to ...
R. Vollenhoven, T. Takeuchi, A. Pangan, A. Friedman, M. Mohamed, Su Chen, M. Rischmueller, R. Blanco, R. Xavier, V. Strand   +9 more
semanticscholar   +1 more source

Medical system error causing methotrexate poisoning and delay in diagnosis: report of two cases

Journal of Emergency Practice and Trauma, 2021
Objective: We are going to alert the emergency physicians to be aware of drugs side effects. Some drugs like methotrexate are not routine drugs, and the symptoms may be miss diagnosed if not completely notified.
Hamidreza Reihani
doaj   +1 more source

Polyglutamation of methotrexate. Is methotrexate a prodrug? [PDF]

Journal of Clinical Investigation, 1985
La polyglutamation est assuree par la folyl polyglutamyl synthetase.
B A, Chabner, C J, Allegra, G A, Curt, N J, Clendeninn, J, Baram, S, Koizumi, J C, Drake, J, Jolivet   +7 more
openaire   +2 more sources

Methotrexate an Old Drug with New Tricks

International Journal of Molecular Sciences, 2019
Methotrexate (MTX) is the first line drug for the treatment of a number of rheumatic and non-rheumatic disorders. It is currently used as an anchor disease, modifying anti-rheumatic drug in the treatment of rheumatoid arthritis (RA).
Y. Bedoui, X. Guillot, Jimmy Selambarom, P. Guiraud, C. Giry, M. Jaffar-Bandjee, S. Ralandison, P. Gasque   +7 more
semanticscholar   +1 more source

Adverse Effects of Low-Dose Methotrexate

Annals of Internal Medicine, 2020
Background Low-dose methotrexate (LD-MTX) is the most commonly used drug for systemic rheumatic diseases worldwide and is the recommended first-line agent for rheumatoid arthritis.
D. Solomon, R. Glynn, E. Karlson, Fengxin Lu, Cassandra Corrigan, J. Colls, Chang Xu, Jean G Macfadyen, M. Barbhaiya, N. Berliner, P. Dellaripa, Brendan M. Everett, A. Pradhan, S. Hammond, M. Murray, Deepak A. Rao, S. Ritter, Anna E. Rutherford, J. Sparks, J. Stratton, Dong-Hyun Suh, S. Tedeschi, K. Vanni, N. Paynter, P. Ridker   +24 more
semanticscholar   +1 more source