Results 31 to 40 of about 154,899 (297)
Arthritis Care &Research, EarlyView.Objective This work aimed to evaluate the pharmacokinetics, efficacy, and safety of upadacitinib, an oral selective JAK inhibitor, in pediatric patients with polyarticular‐course juvenile idiopathic arthritis (pcJIA). Methods In an open‐label, phase 1 study (SELECT‐YOUTH), enrolled patients, aged 2 to <18 years with pcJIA, received body weight–based ...
Hermine I. Brunner +12 more
wiley +1 more source
Histopathological effects of Methotrexate in mice livers [PDF]
Kirkuk Journal of Science, 2014 Background:Methotrexate is a folic acid antagonists that inhibits dihydrofolate reductase, resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis. Methotrexate has been used for the treatment of malignancy, rheumatic disorders,
Asal A. Tawfeeq Sundus M. Taifoor
doaj +1 more source
Arthritis Care &Research, EarlyView.Objective Osteoporosis, a known complication of rheumatoid arthritis (RA), increases the risk of hip fracture, which is associated with high morbidity and mortality. Fracture risk estimates in patients with RA treated with contemporary treatment strategies are lacking.
C. Allyson Jones +5 more
wiley +1 more source
EFFICACY OF FUROSEMIDE IN METHOTREXATE CLEARANCE IN PATIENTS TREATED WITH HIGH DOSE METHOTREXATE
Hematology, Transfusion and Cell Therapy, 2022 Objective: Methotrexate was first used in 1947 as a chemotherapeutic drug in the treatment of acute lymphoblastic leukemia (ALL). Methotrexate has been extensively explored as an anticancer drug since that time.
Saqib Khan +2 more
doaj
PLoS ONE, 2013 BackgroundMethotrexate is a chemotherapeutic agent used to treat a variety of cancers. However, the occurrence of resistance limits its effectiveness. Cytochrome c in its reduced state is less capable of triggering the apoptotic cascade.
Susana Barros +6 more
doaj +1 more source
Induction of Erythrocyte Membrane Blebbing by Methotrexate-Induced Oxidative Stress
Dose-Response, 2022 Methotrexate (MTX) is a common chemotherapeutical agent and folate antagonist with reported apoptotic activity in nucleated cells. The presented research work was planned to investigate the eryptotic effects of methotrexate after the exposure of ...
Tayyba Sattar +5 more
doaj +1 more source
Immunosuppressive Drugs in Early Systemic Sclerosis and Prevention of Damage Accrual
Arthritis Care &Research, EarlyView.Objective Organ damage in patients with systemic sclerosis (SSc) in individual organs such as the lungs may be prevented by receiving immunosuppressive drugs (ISs). A new measure of global organ damage, the Scleroderma Clinical Trials Consortium Damage Index (SCTC‐DI), has allowed us to investigate whether receiving ISs may reduce global organ damage ...
Murray Baron +29 more
wiley +1 more source
Arthritis Care &Research, EarlyView.Objective Targeted synthetic disease‐modifying antirheumatic drugs (tsDMARDs) have expanded the management of autoimmune diseases, including rheumatic diseases. As the use of these drugs grows, it is important to understand their effects on pregnancy.
Vienna Cheng +7 more
wiley +1 more source
Arquivos de Gastroenterologia, 2011 CONTEXT: Methotrexate and other anticancer agents can induce intestinal mucositis, which is one of the most common limiting factor that prevent further dose escalation of the methotrexate. OBJECTIVES: To evaluate the gastric emptying and gastrointestinal
Pedro M. G. Soares +5 more
doaj +1 more source
Frontiers in Pharmacology, 2020 High-dose methotrexate is a cornerstone agent in the chemotherapeutic treatment of patients with osteosarcoma. However, patients often develop methotrexate-induced toxicities.
Evelien G. E. Hurkmans +10 more
doaj +1 more source