Results 21 to 30 of about 137,213 (265)

Methotrexate mediates the integrity of intestinal stem cells partly through nitric oxide-dependent Wnt/β-catenin signaling in methotrexate-induced rat ileal mucositis

Journal of Pharmacological Sciences, 2022
This study aimed to elucidate the role of nitric oxide (NO) in intestinal stem cells in methotrexate-induced ileal mucositis in rats. Methotrexate induced the mRNA expressions of the Wnt/β-catenin target genes Wnt3a, Sox9, and Lgr5 and the Wnt-antagonist
Maiko Machida, Takuji Machida, Masaki Kikuchi, Ayaka Shimizu, Syunsuke Ida, Yoshiki Tawaraya, Risa Kato, Keisuke Haramaki, Kaori Yama, Saki Shiga, Masahiko Hirafuji, Kenji Iizuka   +11 more
doaj   +1 more source

Methotrexate-induced nausea in the treatment of juvenile idiopathic arthritis

Pediatric Rheumatology Online Journal, 2017
Background Methotrexate is the most commonly used disease modifying antirheumatic drug in the treatment of juvenile idiopathic arthritis and can be effective in controlling disease in many patients.
Sonja Falvey, Lauren Shipman, Norman Ilowite, Timothy Beukelman   +3 more
doaj   +1 more source

The role of nitric oxide in small intestine differs between a single and a consecutive administration of methotrexate to rats

Journal of Pharmacological Sciences, 2020
The role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as
Saki Shiga, Takuji Machida, Takumi Yanada, Maiko Machida, Masahiko Hirafuji, Kenji Iizuka   +5 more
doaj   +1 more source

Effects of intraventricular methotrexate administration on Cuprizone-induced demyelination in mice

Frontiers in Molecular Neuroscience, 2013
We previously showed that intrathecal administration of methotrexate slowed disability progression in multiple sclerosis patients with progressive disease. In general MS patients with progressive disease respond poorly to anti-inflammatory therapies.
Andre Michael Mueller, Adam eNassery, Hana eConlon, Xinhe eLiu, Massimiliano eCristofanilli, Esther eJun, Bo Hyung eYoon, Saud Ahmed Sadiq   +7 more
doaj   +1 more source

Rational Use of Herbal Products in Pediatric Patients Treated With Anticancer Drugs in the European Union

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction The use of herbal medical preparation (HMP) is rising among pediatric oncology patients, often to manage treatment‐related symptoms. Their effectiveness remains uncertain, and the risk of herb–drug interactions is underestimated.
Orianne Mahot, Mathieu Corvaisier, Laurence Spiesser‐Robelet, Mylène Duplan, Isabelle Pellier, Delphine Bourneau‐Martin, Séverine Derbré   +6 more
wiley   +1 more source

Childhood Acute Lymphoblastic Leukemia Survival in Western Kenya: Reduction in Early Deaths and Treatment Abandonment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background An earlier study on children diagnosed with acute lymphoblastic leukemia (ALL) at Moi Teaching and Referral Hospital (MTRH) in Kenya reported a low event‐free survival (EFS), excess treatment abandonment, and high induction mortality.
Gilbert Olbara, George Bogonko, Festus Njuguna, Sandra Langat, Martha Kipngetich, Dennis Njenga, Gertjan Johannes Kaspers, Terry Allen Vik   +7 more
wiley   +1 more source

Impact of Bosentan in Ameliorating Methotrexate-Induced Tongue Toxicity in Rats [PDF]

المجلة العراقية للصيدلة
Background and objective: Although methotrexate has been utilized over many years, adverse effects are frequent throughout therapy, especially among cancer patients.
Rana Khairi Attarbashee
doaj   +1 more source

Polyglutamation of methotrexate. Is methotrexate a prodrug? [PDF]

Journal of Clinical Investigation, 1985
La polyglutamation est assuree par la folyl polyglutamyl synthetase.
B A, Chabner, C J, Allegra, G A, Curt, N J, Clendeninn, J, Baram, S, Koizumi, J C, Drake, J, Jolivet   +7 more
openaire   +2 more sources

Tracking Health Related Quality of Life From Diagnosis to Follow‐Up Among Australian Children With Acute Lymphoblastic Leukaemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Acute lymphoblastic leukaemia (ALL) is one of the most treatable forms of paediatric cancer; however, there is a substantial burden of treatment‐related toxicities (TRTs). In addition, the long‐term changes in children's health‐related quality of life (HRQoL) due to toxic treatments are not well understood.
Clare Ghows, Clarissa E. Schilstra, Karen McCleary, Nancy E. Briggs, Rishi S. Kotecha, Richard De Abreu Lourenco, Shanti Ramachandran, Ruelleyn Cockcroft, Rachel Conyers, Siobhan Cross, Luciano Dalla‐Pozza, Peter Downie, Tamas Revesz, Michael Osborn, Frank Alvaro, Claire E. Wakefield, Glenn M. Marshall, Toby Trahair, Marion K. Mateos, Joanna E. Fardell   +19 more
wiley   +1 more source

Methotrexate-induced acute neurotoxicity in patients with osteosarcoma: a case report

Journal of Medical Case Reports
Background Methotrexate is commonly used to treat osteosarcoma and acute lymphoblastic leukemia. Methotrexate can rarely cause neurotoxicity with a wide range of presentations including seizure, hemiparesis, dysarthria, dysphagia, and more.
Olivia L. Makos, Nicole A. Shonka, Kealy M. Marth, Shawna L. Stricker, Mark Keiper, Makayla E. Schissel   +5 more
doaj   +1 more source