Results 11 to 20 of about 185,590 (309)

Leflunomide and methotrexate

Current Opinion in Rheumatology, 2001
Methotrexate and leflunomide are both effective drugs in the treatment of patients with rheumatoid arthritis. Methotrexate has been available for many years, whereas leflunomide is a relatively new drug. Several large trials describing its efficacy and safety in comparison with both sulfasalazine and methotrexate and with placebo have been published ...
Laan, R.F.J.M., Riel, P.L.C.M. van, Putte, L.B.A. van de   +2 more
openaire   +4 more sources

Methotrexate-induced nausea in the treatment of juvenile idiopathic arthritis

Pediatric Rheumatology Online Journal, 2017
Background Methotrexate is the most commonly used disease modifying antirheumatic drug in the treatment of juvenile idiopathic arthritis and can be effective in controlling disease in many patients.
Sonja Falvey, Lauren Shipman, Norman Ilowite, Timothy Beukelman   +3 more
doaj   +2 more sources

Has increased clinical experience with methotrexate reduced the direct costs of medical management of ectopic pregnancy compared to surgery? [PDF]

, 2012
Background - There is a debate about the cost-efficiency of methotrexate for the management of ectopic pregnancy (EP), especially for patients presenting with serum human chorionic gonadotrophin levels of >1500 IU/L.
Wu Olivia, Tong, Stephen, Duncan, W., Olivia Wu, Critchley, HOD, Andrew W Horne, Wu, O., Westaby, Daniel T, Horne, AW, Westaby, D.T., Horne Andrew W, Tong Stephen, Critchley Hilary OD, Duncan W, Duncan, W Colin, Westaby Daniel T, W Colin Duncan, Wu, Olivia, Westaby, DT, Wu, O, Tong, S., Critchley, Hilary Od, Duncan, WC, Horne, A.W., Horne, Andrew W, Critchley, H.O.D., Daniel T Westaby, Hilary OD Critchley, Tong, S, Stephen Tong   +29 more
core   +2 more sources

Methotrexate in the urine [PDF]

Kidney International, 2011
A 62-year-old man with a recent diagnosis of primary central nervous system lymphoma developed acute kidney injury (AKI) after administration of high-dose methotrexate. AKI developed within 48 h of therapy despite prior infusion of intravenous bicarbonate solution. Serum methotrexate level was 2.61 μmol/l at 24 h and 0.25 μmol/l 72 h after methotrexate
Mallipattu, Sandeep K., Ross, Michael J.
openaire   +2 more sources

The potential use of methotrexate in the treatment of falciparum malaria: in vitro assays against sensitive and multidrug-resistant falciparum strains. [PDF]

, 2008
The anti-malarial activity of the anti-cancer drug methotrexate against chloroquine-sensitive T9-96 and the multidrug-resistant K1 strains of Plasmodium falciparum was assessed in vitro.
Dar, O, Adagu, I, Khan, MS, O. Dar, M. S. Khan, I. Adagu   +5 more
core   +1 more source

EFFICACY OF FUROSEMIDE IN METHOTREXATE CLEARANCE IN PATIENTS TREATED WITH HIGH DOSE METHOTREXATE

Hematology, Transfusion and Cell Therapy, 2022
Objective: Methotrexate was first used in 1947 as a chemotherapeutic drug in the treatment of acute lymphoblastic leukemia (ALL). Methotrexate has been extensively explored as an anticancer drug since that time.
Saqib Khan, Tariq Muhammad, Yasmin Abdul Rashid   +2 more
doaj   +1 more source

Hepatic methotrexate-associated lymphoproliferative disorders identified by multiple liver tumors: a case report and review of the literature

Journal of Medical Case Reports, 2019
Background Methotrexate, an immunosuppressant, is widely used as the standard therapeutic drug for rheumatoid arthritis. With the increasing frequency of use of methotrexate, adverse effects of methotrexate have been reported, one of which is known as ...
Ryohei Ono, Tomohiro Kumagae, Haruki Uojima, Shinichi Teshima, Madoka Kudo, Izumi Kitagawa, Masaki Yoshizawa   +6 more
doaj   +1 more source

In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles [PDF]

, 2013
Nanoparticles with pH-sensitive behavior may enhance the success of chemotherapy in many cancers by efficient intracellular drug delivery. Here, we investigated the effect of a bioactive surfactant with pH-sensitive properties on the antitumor activity ...
Vinardell, M. Pilar, Vinardell Martínez-Hidalgo, Ma. Pilar, Mitjans, Montserrat, Mitjans Arnal, Montserrat, Infante, María Rosa, Pérez, Lourdes, Infante Martínez-Pardo, Ma. Rosa, Tavano, Lorena, Nogueira, Daniele R., Nogueira, Daniele Rubert, Pérez Muñoz, Lourdes   +10 more
core   +1 more source

A comparison of vitamin A and leucovorin for the prevention of methotrexate-induced micronuclei production in rat bone marrow

Clinics, 2008
INTRODUCTION: Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis.
Sampath Madhyastha, Latha V Prabhu, V Saralaya, Rajalakshmi Rai   +3 more
doaj   +1 more source

METHOTREXATE USE IS SAFE IN CHILDREN WITH ACUTE LYMPHOBLASTIC LEUKEMIA

Folia Medica Indonesiana, 2017
Monitoring level of methotrexate is not only aimed at monitoring effectiveness, but also safety aspects of the administration of high-dose methotrexate because the use of high-dose methotrexate is one of the problems associated with toxicity in various ...
Febriansyah Nur Utomo, Yulistiani Yulistiani, Nun Zairina, Bambang Permono   +3 more
doaj   +1 more source