Results 11 to 20 of about 166,279 (314)

Has increased clinical experience with methotrexate reduced the direct costs of medical management of ectopic pregnancy compared to surgery? [PDF]

, 2012
Background - There is a debate about the cost-efficiency of methotrexate for the management of ectopic pregnancy (EP), especially for patients presenting with serum human chorionic gonadotrophin levels of >1500 IU/L.
Wu Olivia, Tong, Stephen, Duncan, W., Olivia Wu, Critchley, HOD, Andrew W Horne, Wu, O., Westaby, Daniel T, Horne, AW, Westaby, D.T., Horne Andrew W, Tong Stephen, Critchley Hilary OD, Duncan W, Duncan, W Colin, Westaby Daniel T, W Colin Duncan, Wu, Olivia, Westaby, DT, Wu, O, Tong, S., Critchley, Hilary Od, Duncan, WC, Horne, A.W., Horne, Andrew W, Critchley, H.O.D., Daniel T Westaby, Hilary OD Critchley, Tong, S, Stephen Tong   +29 more
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Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated

, 2023
Background & AimsThe risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated at around 5%, prompting intensive monitoring strategies. However, the evidence is derived from retrospective studies that under-reported
Crooks, Colin, Ala, Aftab, Ruth Murphy, Abhishek, Abhishek, Jane I. Grove, Aftab Ala, Richard J. Aspinall, David Hutchinson, Murphy, Ruth, Esther Burden-Teh, Aspinall, Richard J., Edmond Atallah, Guruprasad P. Aithal, Atallah, Edmond, Moreea, Sulleman, Abhishek Abhishek, Kelsey M. Jordan, Aithal, Guruprasad, Grove, Jane, Jordan, Kelsey, Sulleman Moreea, Burden-Teh, Esther, Hutchinson, David, Colin Crooks   +23 more
core   +1 more source

Anti-inflammatory effects of intravenous methotrexate associated with lipid nanoemulsions on antigen-induced arthritis

Clinics, 2016
OBJECTIVE: To test the hypothesis that intravenous use of methotrexate associated with lipid nanoemulsions can achieve superior anti-inflammatory effects in the joints of rabbits with antigen-induced arthritis compared with commercial methotrexate ...
Suzana B.V. Mello, Elaine R. Tavares, Maria Carolina Guido, Eloisa Bonfá, Raul C. Maranhão   +4 more
doaj   +1 more source

The Possible Ameliorative effect of Zafirlukast on Renal Toxicity Induced by Methotrexate in Experimental Animals [PDF]

Ain Shams Journal of Forensic Medicine and Clinical Toxicology, 2016
Methotrexate is a chemotherapeutic agent. Nephrotoxicity is an important side effect of treatment with methotrexate. Zafirlukast is a cystenyl leukotriene antagonist that acts as an anti-inflammatory and antioxidant agent.
Rasha Ahmed, Mohammed Abbas, Shereen El-sherbeney   +2 more
doaj   +1 more source

The potential use of methotrexate in the treatment of falciparum malaria: in vitro assays against sensitive and multidrug-resistant falciparum strains. [PDF]

, 2008
The anti-malarial activity of the anti-cancer drug methotrexate against chloroquine-sensitive T9-96 and the multidrug-resistant K1 strains of Plasmodium falciparum was assessed in vitro.
Dar, O, Adagu, I, Khan, MS
core   +1 more source

Hepatic methotrexate-associated lymphoproliferative disorders identified by multiple liver tumors: a case report and review of the literature

Journal of Medical Case Reports, 2019
Background Methotrexate, an immunosuppressant, is widely used as the standard therapeutic drug for rheumatoid arthritis. With the increasing frequency of use of methotrexate, adverse effects of methotrexate have been reported, one of which is known as ...
Ryohei Ono, Tomohiro Kumagae, Haruki Uojima, Shinichi Teshima, Madoka Kudo, Izumi Kitagawa, Masaki Yoshizawa   +6 more
doaj   +1 more source

In vitro antitumor activity of methotrexate via pH-sensitive chitosan nanoparticles [PDF]

, 2013
Nanoparticles with pH-sensitive behavior may enhance the success of chemotherapy in many cancers by efficient intracellular drug delivery. Here, we investigated the effect of a bioactive surfactant with pH-sensitive properties on the antitumor activity ...
Vinardell, M. Pilar, Vinardell Martínez-Hidalgo, Ma. Pilar, Mitjans, Montserrat, Mitjans Arnal, Montserrat, Infante, María Rosa, Pérez, Lourdes, Infante Martínez-Pardo, Ma. Rosa, Tavano, Lorena, Nogueira, Daniele R., Nogueira, Daniele Rubert, Pérez Muñoz, Lourdes   +10 more
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A comparison of vitamin A and leucovorin for the prevention of methotrexate-induced micronuclei production in rat bone marrow

Clinics, 2008
INTRODUCTION: Methotrexate, a folate antagonist, is a mainstay treatment for childhood acute lymphoblastic leukemia. It is also widely used in a low dose formulation to treat patients with rheumatoid arthritis.
Sampath Madhyastha, Latha V Prabhu, V Saralaya, Rajalakshmi Rai   +3 more
doaj   +1 more source

Medical system error causing methotrexate poisoning and delay in diagnosis: report of two cases

Journal of Emergency Practice and Trauma, 2021
Objective: We are going to alert the emergency physicians to be aware of drugs side effects. Some drugs like methotrexate are not routine drugs, and the symptoms may be miss diagnosed if not completely notified.
Hamidreza Reihani
doaj   +1 more source

EXACERBATION OF ANKYLOSING SPONDYLITIS AFTER LOW-DOSE METHOTREXATE THERAPY

Alʹmanah Kliničeskoj Mediciny, 2016
Background: Efficacy of methotrexate in ankylosing spondylitis (AS) is disputable. Nevertheless, methotrexate is still used for disease-modifying therapy of AS. Aim: To assess efficacy and safety of methotrexate in AS patients.
A. V. Orlov-Morozov
doaj   +1 more source