Results 31 to 40 of about 185,590 (309)

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

Effects of intraventricular methotrexate administration on Cuprizone-induced demyelination in mice

Frontiers in Molecular Neuroscience, 2013
We previously showed that intrathecal administration of methotrexate slowed disability progression in multiple sclerosis patients with progressive disease. In general MS patients with progressive disease respond poorly to anti-inflammatory therapies.
Andre Michael Mueller, Adam eNassery, Hana eConlon, Xinhe eLiu, Massimiliano eCristofanilli, Esther eJun, Bo Hyung eYoon, Saud Ahmed Sadiq   +7 more
doaj   +1 more source

Abatacept for Prophylaxis of Acute and Chronic Graft‐Versus‐Host‐Disease in Children Undergoing Allogeneic Hematopoietic Stem Cell Transplantation—A Systematic Review and Meta‐Analysis of Cohort Studies

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Graft‐versus‐host disease (GvHD) remains one of the most significant complications of hematopoietic stem cell transplantation (HSCT). Abatacept, a selective T‐cell costimulation modulator, is a relatively novel prophylactic agent, though pediatric data remain limited.
Matthijs D. Kruizinga, Anne B. Verbeek, Caroline A. Lindemans, Emilie P. Buddingh   +3 more
wiley   +1 more source

Methotrexate-Induced Pulmonary Toxicity [PDF]

, 2013
Methotrexate is a widely used medication with an array of recognized side effects. The present report describes a case of methotrexate-induced pneumonitis in a patient with psoriasis, and demonstrates the hallmark clinical and investigational findings ...
Baruch D Jakubovic, Peter M Webster, Andrea Donovan, Neil H Shear, Shear, Neil H, Webster, Peter M, Jakubovic, Baruch D, Donovan, Andrea   +7 more
core   +3 more sources

Methotrexate-induced acute neurotoxicity in patients with osteosarcoma: a case report

Journal of Medical Case Reports
Background Methotrexate is commonly used to treat osteosarcoma and acute lymphoblastic leukemia. Methotrexate can rarely cause neurotoxicity with a wide range of presentations including seizure, hemiparesis, dysarthria, dysphagia, and more.
Olivia L. Makos, Nicole A. Shonka, Kealy M. Marth, Shawna L. Stricker, Mark Keiper, Makayla E. Schissel   +5 more
doaj   +1 more source

The role of nitric oxide in small intestine differs between a single and a consecutive administration of methotrexate to rats

Journal of Pharmacological Sciences, 2020
The role of nitric oxide (NO) on intestinal mucosal injury induced by single or consecutive administration of methotrexate was investigated in a rodent model. Rats received methotrexate intraperitoneally either as a single administration (50 mg/kg) or as
Saki Shiga, Takuji Machida, Takumi Yanada, Maiko Machida, Masahiko Hirafuji, Kenji Iizuka   +5 more
doaj   +1 more source

The role of ultrasonography in methotrexate therapy for ectopic pregnancy

, 2018
Medical management of ectopic pregnancy with methotrexate, an antimetabolite of folic acid, is an important alternative to surgical treatment, as it ensures a similar outcome whilst being far less invasive.
Czuczwar, Piotr, Piotr Czuczwar
core   +1 more source

Delayed Methotrexate Elimination after Administration of a Medium Dose of Methotrexate in a Patient with Genetic Variants Associated with Methotrexate Clearance [PDF]

, 2020
Polymorphisms in methotrexate transporter pathways have been associated with methotrexate toxicities and clearance. Recent genome-wide association studies have revealed that the SLCO1B1 T521C variant is associated with methotrexate elimination.
Tatebe, Yasuhisa, Kitamura, Yoshihisa, Tsukahara, Hirokazu, Fujiwara, Kaori, Shimada, Akira, Kanzaki, Hirotaka, Kanamitsu, Kiichiro, Ishida, Hisashi, Sendo, Toshiaki, Washio, Kana   +9 more
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Impact of Bosentan in Ameliorating Methotrexate-Induced Tongue Toxicity in Rats [PDF]

المجلة العراقية للصيدلة
Background and objective: Although methotrexate has been utilized over many years, adverse effects are frequent throughout therapy, especially among cancer patients.
Rana Khairi Attarbashee
doaj   +1 more source