Results 41 to 50 of about 185,590 (309)

Potential contributors to low dose methotrexate toxicity in a patient with rheumatoid arthritis and pernicious anemia: case report

BMC Rheumatology, 2021
Background Low dose methotrexate toxicity rarely occurs, but may present with severe complications, such as pancytopenia, hepatotoxicity, mucositis, and pneumonitis.
Miguel A. Jara-Palacios, William Chun, Nomi L. Traub   +2 more
doaj   +1 more source

Methotrexate

, 2016
Methotrexate is an analogue of folates (Fig. 1) and is a cytotoxic drug used in the treatment of several malignancies. At low doses, methotrexate is a member of the drug group slow-acting antirheumatic drugs (SAARDs).
Pile, Kevin (R17082), Garry G. Graham, Kevin D. Pile, Graham, Garry G.   +3 more
core   +1 more source

pneumonia prevention in patients undergoing methotrexate therapy for hematological malignancies: A review of the literature

, 2020
Methotrexate is a cytotoxic agent that is commonly used to treat autoimmune diseases, and both solid and hematological malignancies. Drug interactions are of particular concern during methotrexate therapy, as they have the potential to alter the ...
King, LD, Anoopkumar-Dukie, S, Sia, H, Liam D. King, Hanlon Sia, Shailendra Anoopkumar‐Dukie   +5 more
core   +1 more source

Accidental Chronic Poisoning with Methotrexate; Report of Two Cases [PDF]

, 2017
Methotrexate has been used widely in dermatology, oncology and rheumatology fields. However, methotrexate-induced mucocutaneous lesions may occur in rare cases.
Owliaey, Hamid, Mojtaba Babaei Zarch, Bidaki, Reza, Hamid Owliaey, Mojgan Kian, Babaei Zarch, Mojtaba, Kian, Mojgan, Masoud Feysal, Feysal, Masoud, Reza Bidaki   +9 more
core   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

The redox state of cytochrome c modulates resistance to methotrexate in human MCF7 breast cancer cells.

PLoS ONE, 2013
BackgroundMethotrexate is a chemotherapeutic agent used to treat a variety of cancers. However, the occurrence of resistance limits its effectiveness. Cytochrome c in its reduced state is less capable of triggering the apoptotic cascade.
Susana Barros, Núria Mencia, Laura Rodríguez, Carlota Oleaga, Conceição Santos, Verónique Noé, Carlos J Ciudad   +6 more
doaj   +1 more source

Methotrexate Revisited—in Recurrent Head and Neck Cancer

, 2011
Aims Response of single agent chemotherapy in improving quality of life in patients with recurrent head and neck cancers. Methods and material This is a study of the 18 patients with advanced cancers of head and neck, who had failed earlier attempts of ...
R.P.S. Banipal, M.K. Mahajan
core   +1 more source

Dactolisib outperforms Rapamycin in potentiating apoptosis induced by XPO1, Bcl‐2 and Mcl‐1 blockade in preclinical glioblastoma models

FEBS Open Bio, EarlyView.
The PAM pathway and its impact on cellular metabolism. Color‐coded key symbols represent Rapamycin (R, orange, targeting mTOR) and Dactolisib (D, green, targeting PI3K/mTOR), indicating their sites of action. Created with BioRenders.com. Glioblastoma resists therapy through interconnected survival programs.
Kai Zhao, Leonie Meyer, Madita Braun, Katharina Otte, Celine Bitter, Maite Pawlik, Hartmann Raifer, Frederik Helmprobst, Axel Pagenstecher, Hans Urban, Michael C. Burger, Michael W. Ronellenfitsch, Joachim P. Steinbach, Jarmila Jedelská, Shamim Bagheri, Behrooz H. Yousefi, Pietro Di Fazio, Markus Luster, Andreas H. Mahnken, Andreas Neubauer, Andreas Burchert, Christopher Nimsky, Jörg W. Bartsch, Tillmann Rusch   +23 more
wiley   +1 more source

Factors related to dosing frequency and route of administration in methotrexate intolerance among patients with rheumatoid arthritis: a cross-sectional study

Therapeutic Advances in Drug Safety
Background: Methotrexate is central to the management of rheumatoid arthritis (RA). However, its use is often limited by methotrexate intolerance. Objectives: This study aims to explore the association between alternative methotrexate dosing methods and ...
Haya M. Almalag, Jawza F. Alsabhan, Abdurhman S. Alarfaj, Eman Alfi, Shorouq Albalawi, Asma A. Al-Shadaawi, Sahar A. Alshehri, Ghadah Asaad Assiri, Ibrahim Almaghlouth, Mohammed A. Omair   +9 more
doaj   +1 more source

Nitric oxide plays a critical role in methotrexate-induced hyperplasia of enterochromaffin cells containing 5-hydroxytryptamine in rat small intestine

Journal of Pharmacological Sciences, 2019
The role of nitric oxide (NO) in the changes in enterochromaffin cells and ileal 5-hydroxytryptamine (5-HT) content induced by a single i.p. administration of methotrexate was investigated in rats.
Yuho Takano, Megumi Hirano, Takuji Machida, Yusuke Obara, Naoya Hamaue, Kana Fujita, Masafumi Taniguchi, Tomoko Endo, Saki Shiga, Maiko Machida, Kenji Iizuka, Masahiko Hirafuji   +11 more
doaj   +1 more source