Results 71 to 80 of about 369,868 (397)
Arthritis Care &Research, EarlyView.As many patients with inflammatory arthritis (IA) have chronic pain, understanding how to best assess and manage pain in IA is a priority. Comorbid depression is prevalent in adults with IA, affecting 15% to 39% of people. Although pain and depression are thought to be associated in IA, this concept is largely based on cross‐sectional data.
Natasha Cox +3 more
wiley +1 more source
Journal of Pharmacological Sciences, 2019 The role of nitric oxide (NO) in the changes in enterochromaffin cells and ileal 5-hydroxytryptamine (5-HT) content induced by a single i.p. administration of methotrexate was investigated in rats.
Yuho Takano +11 more
doaj +1 more source
Recent advances: rheumatology [PDF]
, 2000 No abstract ...
Madhok, R., Kerr, H., Capell, H.A.
core +4 more sources
Arthritis Care &Research, EarlyView.Objective Systemic sclerosis (SSc) is a rare autoimmune disease characterized by tissue fibrosis, vasculopathy, and immune dysregulation. Our objectives were to quantify the overall and site‐specific cancer risks in patients with SSc compared to the general population, examine temporal trends in cancer incidence following SSc diagnosis, and explore ...
Jihyun Na +4 more
wiley +1 more source
SLC19A1 transports immunoreactive cyclic dinucleotides. [PDF]
, 2019 The accumulation of DNA in the cytosol serves as a key immunostimulatory signal associated with infections, cancer and genomic damage1,2. Cytosolic DNA triggers immune responses by activating the cyclic GMP-AMP synthase (cGAS)-stimulator of interferon ...
Corn, Jacob E +10 more
core
Methotrexate in the urine [PDF]
Kidney International, 2011 A 62-year-old man with a recent diagnosis of primary central nervous system lymphoma developed acute kidney injury (AKI) after administration of high-dose methotrexate. AKI developed within 48 h of therapy despite prior infusion of intravenous bicarbonate solution. Serum methotrexate level was 2.61 μmol/l at 24 h and 0.25 μmol/l 72 h after methotrexate
Mallipattu, Sandeep K., Ross, Michael J.
openaire +2 more sources
Arthritis & Rheumatology, 2017 We undertook this phase III study to evaluate baricitinib, an orally administered JAK‐1/JAK‐2 inhibitor, as monotherapy or combined with methotrexate (MTX) compared to MTX monotherapy in patients with active rheumatoid arthritis (RA) who had received no ...
R. Fleischmann +15 more
semanticscholar +1 more source
Arthritis Care &Research, EarlyView.We report the national burden of dermatopolymyositis mortality over the past quarter century using the US national vital statistics data. Age‐standardized mortality rates for dermatopolymyositis decreased at an annual rate of 3.8% each year, which was higher than the annual percent decrease for deaths from all other causes.
Elizabeth Matz, Ram R. Singh
wiley +1 more source
Therapeutic Advances in Drug SafetyBackground: Methotrexate is central to the management of rheumatoid arthritis (RA). However, its use is often limited by methotrexate intolerance. Objectives: This study aims to explore the association between alternative methotrexate dosing methods and ...
Haya M. Almalag +9 more
doaj +1 more source
Histopathological effects of Methotrexate in mice livers [PDF]
Kirkuk Journal of Science, 2014 Background:Methotrexate is a folic acid antagonists that inhibits dihydrofolate reductase, resulting in a block in the synthesis of thymidine and inhibition of DNA synthesis. Methotrexate has been used for the treatment of malignancy, rheumatic disorders,
Asal A. Tawfeeq Sundus M. Taifoor
doaj +1 more source