Results 1 to 10 of about 2,022 (146)

Exploring the mechanism of Liuwei Dihuang formula for promoting melanin synthesis in juvenile zebrafish based on network pharmacology and molecular docking [PDF]

Heliyon, 2023
Background: Vitiligo stands as a challenging skin disorder with limited treatment options available. LiuWei DiHuang formula (LDF), a renowned Traditional Chinese medicine, has exhibited promising results in treating vitiligo over an extended period ...
Dandan Wang, Yan Yang, Gulijiayina Hengerjia, Yan Deng   +3 more
doaj   +2 more sources

Methoxsalen deteriorative effects on the testicular parenchyma and testosterone synthesis gene expression in male rats [PDF]

Scientific Reports
Studies show that psoralens have adverse effects on the reproductive system. This study investigated the impact of methoxsalen in combination with UVA on testicular parenchyma and the expression level of testosterone synthesis pathway genes as well as ...
Zahra Gholipour, Abbas Fazlinia, Farhad Koohpeyma, Hediye Fahandezh Saadi, Mesbah Shams, Sanaz Dastghaib   +5 more
doaj   +2 more sources

Clinical and dermoscopic assessment of the efficacy of topical trichloroacetic acid 70% versus methoxsalen 0.2% paint in stable acral vitiligo [PDF]

Scientific Reports
Loss and absence of melanocytes due to a number of factors is responsible for vitiligo; known to be the commonest disorder of pigmentation. The aim of the study was to assess clinically and dermoscopically the efficacy of topical trichloroacetic acid 70%
Ahmed R. Elshahed, Amr M. Ammar, Abdallah M. Ali, Mohamed L. Elsaie   +3 more
doaj   +2 more sources

Plant-Assisted Synthesis, Phytochemical Profiling, and Bioactivity Evaluation of Copper Nanoparticles Derived from Tordylium trachycarpum (Apiaceae) [PDF]

Biomolecules
Tordylium trachycarpum Boiss. (Apiaceae) has long been used by traditional healers in the Kurdistan Region of Iraq to alleviate gastrointestinal disorders and oral inflammation; however, its phytochemical composition and pharmacological properties remain
Venos Saeed Abdullah, Kamaran Younis M. Amin, Hawraz Ibrahim M. Amin   +2 more
doaj   +2 more sources

A randomized phase II study of SM‐88 plus methoxsalen, phenytoin, and sirolimus in patients with metastatic pancreatic cancer treated in the second line and beyond [PDF]

Cancer Medicine, 2022
Background This trial explores SM‐88 used with methoxsalen, phenytoin, and sirolimus (MPS) in pretreated metastatic pancreatic ductal adenocarcinoma (mPDAC) Methods Forty‐nine patients were randomized to daily 460 or 920 mg oral SM‐88 with MPS (SM‐88 ...
Marcus S. Noel, Semmie Kim, Marion L. Hartley, Steve Wong, Vincent J. Picozzi, Harry Staszewski, Dae Won Kim, Jan M. Van Tornout, Philip Agop Philip, Vincent Chung, Allyson J. Ocean, Andrea Wang‐Gillam   +11 more
doaj   +3 more sources

Phytochemistry and Allelopathic Properties of Invasive Heracleum sosnowskyi Aqueous Extracts Against Lettuce (Lactuca sativa L.), Perennial Ryegrass (Lolium perenne L.), Timothy (Phleum pratense L.) and White Clover (Trifolium repens L.) [PDF]

Plants
Heracleum sosnowskyi is considered to be a dangerous invasive plant species that has successfully naturalized within a variety of plant communities across numerous countries.
Asta Judžentienė, Aistė Kundrotaitė, Tatjana Charkova, Irena Nedveckytė   +3 more
doaj   +2 more sources

Group I pharmaceuticals of IARC and associated cancer risks: systematic review and meta-analysis [PDF]

Scientific Reports
We aimed to summarize the cancer risk among patients with indication of group I pharmaceuticals as stated in monographs presented by the International Agency for Research on Cancer working groups.
Woojin Lim, Sungji Moon, Na Rae Lee, Ho Gyun Shin, Su-Yeon Yu, Jung Eun Lee, Inah Kim, Kwang-Pil Ko, Sue K. Park   +8 more
doaj   +2 more sources

Senotherapeutic Potential of Araliadiol in Senescent Human Dermal Fibroblasts: An In Vitro Study Using Three Senescence Models [PDF]

Pharmaceutics
Background/Objectives: With the rapid aging of the global population, the interest in therapies for age-related diseases has increased substantially. The skin is particularly important, as aging-related changes are visible and negatively impact quality ...
Seokmuk Park, Seyeol Baek, Hee-Jae Shin, Jeong Yi Hwang, Dae Sung Yoo, Dae Bang Seo, Seunghee Bae   +6 more
doaj   +2 more sources

Methoxsalen-induced macular toxicity

Indian Journal of Ophthalmology, 2017
Psoralen compounds such as methoxsalen are photosensitizer agents used in conjunction with ultraviolet A (UVA) radiation exposure as photochemotherapy (Psoralens and ultraviolet-A therapy [PUVA therapy]) for certain epidermal skin disorders such as ...
Aditya Maitray, Pukhraj Rishi
doaj   +3 more sources

Extracorporeal photopheresis (ECP) in the treatment of chronic lung allograft dysfunction (CLAD): a prospective, multicentre, open-label, randomised controlled trial studying the addition of ECP to standard care in the treatment of bilateral lung transplant patients with CLAD (E-CLAD UK) [PDF]

BMJ Open Respiratory Research
Background Long-term survival after lung transplantation is limited compared with other organ transplants. The main cause is development of progressive immune-mediated damage to the lung allograft.
Martin Carby, Jasvir Parmar, Andrew Bryant, Thomas Chadwick, Luke Vale, Catherine Exley, Andrew J Fisher, Helen Hancock, Richard Thompson, Joanne Lally, Andrew R Gennery, Michelle Bardgett, Siân Russell, Michael White, James MS Wason, Nicola Goudie, Anneka Kershaw, Julia Phillipson, Alex Bevin-Nicholls, Hesther Smith, Laura Frisby, Rebecca Errington, Karthik Santhanakrishnan   +22 more
doaj   +2 more sources