Results 1 to 10 of about 1,920 (175)

Methoxsalen and Bergapten Prevent Diabetes-Induced Osteoporosis by the Suppression of Osteoclastogenic Gene Expression in Mice

International Journal of Molecular Sciences, 2019
This study evaluated whether bergapten and methoxsalen could prevent diabetes-induced osteoporosis and its underlying mechanism. For 10 weeks, bergapten or methoxsalen (0.02%, w/w) was applied to diabetic mice that were provided with a high-fat diet and ...
J. Ham, Ra-Yeong Choi, Hae-in Lee, Mi-Kyung Lee   +3 more
semanticscholar   +1 more source

Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment

Journal of drug targeting (Print), 2016
The present investigation aimed for the development and characterization of ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery and effective treatment against vitiligo.
B. Garg, N. Garg, S. Beg, Bhupinder Singh, O. Katare   +4 more
semanticscholar   +1 more source

Extraction, Isolation, and Purification of Furanocoumarins from Invasive Heracleum sosnowskyi

Separations
Heracleum sosnowskyi Manden. (Sosnowsky’s hogweed), originally introduced to Central and Eastern Europe as a fodder crop, has become a highly invasive species due to its ecological adaptability, high reproductive capacity, and efficient seed dispersal ...
Vida Vickackaite, Karina Pilaityte, Vilius Poskus   +2 more
doaj   +1 more source

Melanocyte transplantation to skin prepared by controlled PUVA-induced sunburn-like blistering for vitiligo treatment – A pilot clinical trial

Journal of the Formosan Medical Association
Vitiligo is a common acquired disease of pigment loss. In lesions recalcitrant to non-invasive treatment, transplantation of cultured autologous melanocytes is an emerging choice.
Po-Hua Chen, Sabrina Mai-Yi Fan, Bin-Ru She, Yi-Ping Wu, Hsiang-Chun Hsu, Ying-Jung Yang, Jun-Jae Huang, Shu-Fen Yeh, Yi-Chen Chen, Pei-Ju Lin, Wann-Hsin Chen, Hsien-Ching Chiu, Hsin-Su Yu, Chih-Ching Liao, Sung-Jan Lin   +14 more
doaj   +1 more source

8-methoxsalen photochemistry enhances tumor cell immunogenicity by inducing ferroptosis in B16 cells

Zhongguo shuxue zazhi
[Objective] To study the efficacy of photosensitizer 8- methoxsalen (8-MOP) combined with ultraviolet radiation A (UVA) in inducing ferroptosis in mouse melanoma B16 cells, and to assess the resultant changes in immunogenicity, and their impact on ...
ZHONG Yan, LIN Yuwei, CHEN Wei, TIAN Li, LI Ling, LIU Zhong   +5 more
doaj   +1 more source

Topical Psoralen and Sunlight in Treatment of Palmoplantar Psoriasis in Iraqi Patients

Diyala Journal of Medicine, 2019
Back ground: Topical psoralens plus sunlight is a common practice among Dermatologists in the world for treatment of various skin diseases like Vitiligo and Psoriasis.  objective:  To test the effectiveness and safety profile of topical psoralen plus
Mohammed Ahmed Mahdi
doaj   +2 more sources

DETERMINATION OF RESIDUAL DIMETHYL SULFATE IN METHOXSALEN DRUG SUBSTANCE BY PRE-COLUMN DERIVATIZATION WITH STATIC HEADSPACE GAS CHROMATOGRAPHY

International Journal of Pharmacy and Pharmaceutical Sciences, 2018
Objective: Dimethyl sulfate has been highlighted as potential genotoxic and carcinogenic impurity. A sensitive Headspace gas chromatography (HS-GC) method with pre-column derivatization was developed and validated for the determination of dimethyl ...
A. Anerao, B. Patil, N. Pradhan
semanticscholar   +1 more source

The potential of xanthotoxin in the treatment of cognitive disorders: current insights and future perspectives

Future Journal of Pharmaceutical Sciences
Background The prevalence of cognitive diseases, including Alzheimer’s disease and other forms of dementia, poses a significant global health challenge due to the limited availability of effective therapeutic options.
Uma Agarwal, Arzoo Pannu, Rajiv Kumar Tonk, Puja Jaiswal, Kajal Jain   +4 more
doaj   +1 more source

Efficacy of Methoxsalen Sterile Solution in Conjunction with the Therakos® Cellex® Photopheresis System in Pediatric Patients with Steroid-Refractory Acute GvHD: Interim Analysis

Blood, 2019
Background: Steroid-refractory acute graft-versus-host disease (SR-aGvHD) is a major cause of morbidity and mortality after allogeneic hematopoietic stem cell transplant in pediatric patients.
C. Kitko, S. Gaspari, Henri Boodée
semanticscholar   +1 more source

Design, synthesis of new 4,5-dibenzylidene-9,10-diphenyl-1,2,7,8,9,10 hexahydroacridine-3,6-dione derivatives using extract of Vitexnegundo: Cytotoxic activity & molecular docking study

Chemical Physics Impact
Among phytochemical and pharmaceutical investigations, the green production of silver nanoparticles has emerged as the crown jewel of this investigation.
Perumal Gobinath, Ponnusamy Packialakshmi, Govindasamy Thilagavathi, Natarajan Elangovan, Renjith Thomas, Radhakrishnan Surendrakumar   +5 more
doaj   +1 more source