Results 1 to 10 of about 2,112 (168)

A randomized phase II study of SM‐88 plus methoxsalen, phenytoin, and sirolimus in patients with metastatic pancreatic cancer treated in the second line and beyond [PDF]

Cancer Medicine, 2022
Background This trial explores SM‐88 used with methoxsalen, phenytoin, and sirolimus (MPS) in pretreated metastatic pancreatic ductal adenocarcinoma (mPDAC) Methods Forty‐nine patients were randomized to daily 460 or 920 mg oral SM‐88 with MPS (SM‐88 ...
Marcus S. Noel, Semmie Kim, Marion L. Hartley, Steve Wong, Vincent J. Picozzi, Harry Staszewski, Dae Won Kim, Jan M. Van Tornout, Philip Agop Philip, Vincent Chung, Allyson J. Ocean, Andrea Wang‐Gillam   +11 more
doaj   +6 more sources

Clinical and dermoscopic assessment of the efficacy of topical trichloroacetic acid 70% versus methoxsalen 0.2% paint in stable acral vitiligo [PDF]

Scientific Reports
Loss and absence of melanocytes due to a number of factors is responsible for vitiligo; known to be the commonest disorder of pigmentation. The aim of the study was to assess clinically and dermoscopically the efficacy of topical trichloroacetic acid 70%
Ahmed R. Elshahed, Amr M. Ammar, Abdallah M. Ali, Mohamed L. Elsaie   +3 more
doaj   +3 more sources

Novel inactivation of the causative fungal pathogen of white-nose syndrome with methoxsalen plus ultraviolet A or B radiation. [PDF]

PLoS ONE, 2020
White-nose syndrome is a fungal disease responsible for the rapid decline of North American bat populations. This study addressed a novel method for inactivating Pseudogymnoascus destructans, the causative agent of WNS, using ultraviolet A (UVA) or B ...
Colin J Hartman, Joseph C Mester, Patrick M Hare, Alan I Cohen   +3 more
doaj   +5 more sources

Protective Effects of Methoxsalen Supplementation on Chronic Alcohol-induced Osteopenia and Steatosis in Rats [PDF]

Molecules, 2020
Osteopenia or osteoporosis occurs frequently in alcoholics and patients with alcoholic fatty liver disease. Methoxsalen (MTS), 8-methoxypsoralen, improved osteoporosis in ovariectomized and diabetic mouse models; however, its effects on alcohol-induced ...
Ju Ri Ham, Ra-Yeong Choi, Hae-In Lee, Mi-Kyung Lee   +3 more
doaj   +2 more sources

Exploring the mechanism of Liuwei Dihuang formula for promoting melanin synthesis in juvenile zebrafish based on network pharmacology and molecular docking [PDF]

Heliyon, 2023
Background: Vitiligo stands as a challenging skin disorder with limited treatment options available. LiuWei DiHuang formula (LDF), a renowned Traditional Chinese medicine, has exhibited promising results in treating vitiligo over an extended period ...
Dandan Wang, Yan Yang, Gulijiayina Hengerjia, Yan Deng   +3 more
doaj   +2 more sources

Stability-indicating RP-HPLC method for simultaneous determination of methoxsalen and p-aminobenzoic acid in binary combination

Bulletin of the Chemical Society of Ethiopia, 2015
An accurate, simple and specific reverse phase LC procedure is established and validated for simultaneous estimation of methoxsalen and p-aminobenzoic acid in pharmaceutical formulated products and human serum.
P. John, W. Azeem, M. Ashfaq, I. U. Khan, S. N. Razzaq, S. Ud-Din Khan   +5 more
doaj   +3 more sources

Group I pharmaceuticals of IARC and associated cancer risks: systematic review and meta-analysis [PDF]

Scientific Reports
We aimed to summarize the cancer risk among patients with indication of group I pharmaceuticals as stated in monographs presented by the International Agency for Research on Cancer working groups.
Woojin Lim, Sungji Moon, Na Rae Lee, Ho Gyun Shin, Su-Yeon Yu, Jung Eun Lee, Inah Kim, Kwang-Pil Ko, Sue K. Park   +8 more
doaj   +2 more sources

Extracorporeal photopheresis (ECP) in the treatment of chronic lung allograft dysfunction (CLAD): a prospective, multicentre, open-label, randomised controlled trial studying the addition of ECP to standard care in the treatment of bilateral lung transplant patients with CLAD (E-CLAD UK) [PDF]

BMJ Open Respiratory Research
Background Long-term survival after lung transplantation is limited compared with other organ transplants. The main cause is development of progressive immune-mediated damage to the lung allograft.
Martin Carby, Jasvir Parmar, Andrew Bryant, Thomas Chadwick, Luke Vale, Catherine Exley, Andrew J Fisher, Helen Hancock, Richard Thompson, Joanne Lally, Andrew R Gennery, Michelle Bardgett, Siân Russell, Michael White, James MS Wason, Nicola Goudie, Anneka Kershaw, Julia Phillipson, Alex Bevin-Nicholls, Hesther Smith, Laura Frisby, Rebecca Errington, Karthik Santhanakrishnan   +22 more
doaj   +2 more sources

Methoxsalen-induced macular toxicity

Indian Journal of Ophthalmology, 2017
Psoralen compounds such as methoxsalen are photosensitizer agents used in conjunction with ultraviolet A (UVA) radiation exposure as photochemotherapy (Psoralens and ultraviolet-A therapy [PUVA therapy]) for certain epidermal skin disorders such as ...
Aditya Maitray, Pukhraj Rishi
doaj   +2 more sources

The adverse effects of the methoxsalen and ultraviolent A radiation on spermatogenesis in mice [PDF]

Iranian Journal of Reproductive Medicine, 2015
Background: Different investigation showed that 5-methoxypsoralen and 8- methoxypsoralen reduce birth rates in the rats. Objective: In this study we worked out the effect of methoxsalen together with ultraviolent A (UVA) radiation on mature Balb/C mice ...
Mona Farhadi, Homa Mohseni Kouchesfahani, Abass Shockravi, MosaeebForoozanfar, Kazem Parivar   +4 more
doaj   +1 more source