Allylnitrile metabolism by CYP2E1 and other CYPs leads to distinct lethal and vestibulotoxic effects in the mouse [PDF]
, 2008 This study addressed the hypothesis that the vestibular or lethal toxicities of allylnitrile depend on CYP2E1-mediated bioactivation. Wild-type (129S1) and CYP2E1-null male mice were exposed to allylnitrile at doses of 0, 0.5, 0.75, or 1.0 mmol/kg (po ...
Bayona i Termens, Josep Maria +6 more
core +4 more sources
Cytochrome P450 CYP1B1 interacts with 8-methoxypsoralen (8-MOP) and influences psoralen-Ultraviolet A (PUVA) sensitivity [PDF]
, 2013 Background: There are unpredictable inter-individual differences in sensitivity to psoralen-UVA (PUVA) photochemotherapy, used to treat skin diseases including psoriasis.
Deeni, Yusuf Y. +4 more
core +3 more sources
Scientific Reports, 2022 Psoralen derivatives are well known for their unique phototoxicity and also exhibits promising anti-breast cancer activity both in the presence and the absence of UVA irradiation.
Chiphada Aekrungrueangkit +7 more
doaj +1 more source
Early and Late Side Effects Associated with Photo(chemo)therapy [PDF]
, 2010 Phototherapy (PUVA ve UVB) is a widely used and effective treatment method for a variety of dermatological diseases. Adverse effects associated with phototherapy can be classified as acute and chronic side effects.
Günseli Öztürk
core +1 more source
Heterogeneous lupus‐specific lesions and treatment outcome, in a single patient, over a period of time [PDF]
, 2019 The report highlights the importance of strict clinico-histological correlations when skin biopsies are performed in diagnostic doubt in systemic lupus erythematosus.
Agostini, Patrick +5 more
core +2 more sources
The Adverse Effects of Methoxsalen on The Oogenesis of Balb/C Mice [PDF]
Cell Journal, 2013 Objective: Methoxsalen is a natural photoactive compound which is found in many seed plants. A number of epidermal proliferative disorders can be treated by methoxsalen along with long wave ultraviolet A (UVA).Materials and Methods: In an experimental ...
Abbas Shockravi +4 more
doaj
A Case of Psoriasis Complicated by Breast Cancer after Systemic Treatments Including Biologics [PDF]
, 2018 Psoriasis is a common chronic inflammatory skin disorder that is characterized by scaly, erythematous, sharply demarcated plaques. The treatment for psoriasis has dramatically changed over the last 10 years with the introduction of biologics.
Iwatsuki, Keiji +5 more
core +1 more source
International Journal of Molecular Sciences, 2019 This study evaluated whether bergapten and methoxsalen could prevent diabetes-induced osteoporosis and its underlying mechanism. For 10 weeks, bergapten or methoxsalen (0.02%, w/w) was applied to diabetic mice that were provided with a high-fat diet and ...
J. Ham +3 more
semanticscholar +1 more source
A Perspective on the Use of NB-UVB Phototherapy vs. PUVA Photochemotherapy [PDF]
, 2018 Narrowband UVB (NB-UVB) phototherapy and psoralen-UVA (PUVA) photochemotherapy are widely used phototherapeutic modalities for a range of skin diseases.
Ahmad +119 more
core +3 more sources
The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice. [PDF]
, 2020 During tobacco and e-cigarette use, nicotine is mainly metabolized in the human liver by cytochrome P450 2A6 (CYP2A6). Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studies ...
Chen, Yen-Chu +8 more
core