Transcutol® p containing slns for improving 8-methoxypsoralen skin delivery [PDF]
, 2020 Topical psoralens plus ultraviolet A radiation (PUVA) therapy consists in the topical application of 8-methoxypsoralen (8-MOP) followed by the skin irradiation with ultraviolet A radiation.
Cardia M. C. +8 more
core +1 more source
Pharmacological properties of bergapten: mechanistic and therapeutic aspects [PDF]
, 2022 Bergapten (BP) or 5-methoxypsoralen (5-MOP) is a furocoumarin compound mainly found in bergamot essential oil but also in other citrus essential oils and grapefruit juice.
Bagiu, Iulia Cristina +21 more
core +1 more source
Deuterated Alkyl Sulfonium Salt Reagents; Importance of H/D Exchange Methods in Drug Discovery
ChemMedChem, Volume 19, Issue 16, August 19, 2024.Recently, deuterated drugs have been highlighted as a new modality, and H/D exchange reactions are powerful and straightforward synthetic tools. We have successfully established a novel concept to diversify deuterium drug discovery using dn‐alkylation reagents (dn‐alkyl diphenylsulfonium salts) with excellent D contents and perfect site selectivity ...
Riku Ogasahara +4 more
wiley +1 more source
Novel Inactivation of the Causative Fungus of White Nose Syndrome with Methoxsalen and Ultraviolet A Light [PDF]
, 2018 White Nose Syndrome (WNS) is a newly recognized disease responsible for the rapid mass destruction of the North American bat populations. This study addressed the novel inactivation of fungal spores from Pseudogymnoascus destructans, the causative agent ...
Cohen MD, Alan +2 more
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The Effect of Psoralens on Hepatic and Cutaneous Drug Metabolizing Enzymes and Cytochrome P-450 [PDF]
, 1982 Psoralens are tricyclic furocoumarins with potent photosensitizing properties in the skin and are now widely used in the treatment of several dermatologic diseases.
Bickers, David R. +3 more
core +1 more source
Clinical Case Reports, Volume 12, Issue 3, March 2024.Key clinical message We present a case of primary cutaneous plasmacytosis without systemic involvement. The patient received topical corticosteroids and psoralen plus ultraviolet A therapy, showing significant improvement. Continuous monitoring is underway despite the rarity of systemic manifestations.
Thanyathorn Nuchanatanon +2 more
wiley +1 more source
Psoralen and ultraviolet A irradiation (PUVA) as therapy for steroid-resistant cutaneous acute graft-versus-host disease [PDF]
, 2002 Psoralen plus ultraviolet A irradiation (PUVA) has immunomodulatory effects and is used to treat a variety of immune-mediated dermatologic diseases. We administered PUVA to 103 patients for treatment of steroid-resistant acute graft-versus-host disease ...
Anasetti, Claudio +13 more
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The Journal of Dermatology, Volume 51, Issue 3, Page 365-379, March 2024.Abstract Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in Japan for adult patients with plaque (PP), generalized pustular (GPP), and erythrodermic (EP) psoriasis who have had an inadequate response to conventional systemic therapies.
Shinichi Imafuku +8 more
wiley +1 more source
DETERMINATION OF RESIDUAL DIMETHYL SULFATE IN METHOXSALEN DRUG SUBSTANCE BY PRE-COLUMN DERIVATIZATION WITH STATIC HEADSPACE GAS CHROMATOGRAPHY [PDF]
, 2018 Objective: Dimethyl sulfate has been highlighted as potential genotoxic and carcinogenic impurity. A sensitive Headspace gas chromatography (HS-GC) method with pre-column derivatization was developed and validated for the determination of dimethyl ...
Anerao, Ajit +2 more
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The Evaluation of CP-001 (a Standardized Herbal Mixture of Houttuynia cordata [PDF]
, 2013 In the present study, the effect of CP-001, a standardized herbal mixture of Houttuynia cordata, Rehmannia glutinosa, Betula platyphylla, and Rubus coreanus, on cytochrome P450 (CYP) enzyme-mediated drug metabolism was investigated in vitro to evaluate ...
Hye Hyun Yoo +3 more
core +2 more sources