Psoralen and ultraviolet A irradiation (PUVA) as therapy for steroid-resistant cutaneous acute graft-versus-host disease [PDF]
, 2002 Psoralen plus ultraviolet A irradiation (PUVA) has immunomodulatory effects and is used to treat a variety of immune-mediated dermatologic diseases. We administered PUVA to 103 patients for treatment of steroid-resistant acute graft-versus-host disease ...
Anasetti, Claudio +13 more
core +1 more source
Heterogeneous lupus‐specific lesions and treatment outcome, in a single patient, over a period of time [PDF]
, 2019 The report highlights the importance of strict clinico-histological correlations when skin biopsies are performed in diagnostic doubt in systemic lupus erythematosus.
Agostini, Patrick +5 more
core +2 more sources
Journal of drug targeting (Print), 2016 The present investigation aimed for the development and characterization of ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery and effective treatment against vitiligo.
B. Garg +4 more
semanticscholar +1 more source
The Novel CYP2A6 Inhibitor, DLCI-1, Decreases Nicotine Self-Administration in Mice. [PDF]
, 2020 During tobacco and e-cigarette use, nicotine is mainly metabolized in the human liver by cytochrome P450 2A6 (CYP2A6). Given that a slower CYP2A6 metabolism has been associated with less vulnerability to develop nicotine dependence, the current studies ...
Chen, Yen-Chu +8 more
core
Incidence and Risk Factors Associated with a Second Squamous Cell Carcinoma or Basal Cell Carcinoma in Psoralen + Ultraviolet A Light-treated Psoriasis Patients [PDF]
, 2002 Psoralen + ultraviolet A-treated psoriasis patients are at increased risk for squamous cell carcinomas and basal cell carcinomas; however, the incidence and risk factors associated with second squamous cell carcinomas and basal cell carcinomas in this ...
Katz, Kenneth A. +2 more
core +1 more source
Molecular Mechanisms Associated with Nicotine Pharmacology and Dependence. [PDF]
, 2020 Tobacco dependence is a leading cause of preventable disease and death worldwide. Nicotine, the main psychoactive component in tobacco cigarettes, has also been garnering increased popularity in its vaporized form, as derived from e-cigarette devices ...
A Ashoor +146 more
core +1 more source
Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]
, 2009 In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho +3 more
core +1 more source
Clinical Pharmacology &Therapeutics, Volume 116, Issue 4, Page 948-962, October 2024.The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the human CYP2A gene locus containing the highly polymorphic CYP2A6 gene. CYP2A6 plays a role in the metabolism of nicotine and various drugs. Thus, genetic variation can substantially contribute to the function of this enzyme and associated efficacy and safety.
Alec W.R. Langlois +9 more
wiley +1 more source
Methoxsalen loaded chitosan coated microemulsion for effective treatment of psoriasis [PDF]
, 2011 Methoxsalen has been used for the treatment of psoriasis. In order to develop alternative formulations for the topical administration of methoxsalen, chitosan coated microemulsion were evaluated as delivery vehicle.
Behera, Jitendra +4 more
core +1 more source
Natural Coumarins: QSTR Approaches Regarding Their Genotoxicity [PDF]
, 2015 The 18th International Electronic Conference on Synthetic Organic Chemistry session Computational ChemistryCoumarins are a group of phytochemicals with multiple applications in different fields, such as food and medicine. Many of their benefits are based
Abreu, Orlando +5 more
core +1 more source