Results 51 to 60 of about 2,832 (233)

Nanosized ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery against vitiligo: formulation optimization, in vitro evaluation and preclinical assessment

Journal of drug targeting (Print), 2016
The present investigation aimed for the development and characterization of ethosomes-based hydrogel formulations of methoxsalen for enhanced topical delivery and effective treatment against vitiligo.
B. Garg, N. Garg, S. Beg, Bhupinder Singh, O. Katare   +4 more
semanticscholar   +1 more source

Investigation of chemical constituents of Eranthis longistipitata (Ranunculaceae): coumarins and furochromones [PDF]

, 2021
Aqueous‐ethanol extracts (70%) from the leaves of Eranthis longistipitata Regel. (Ranunculaceae Juss.)—collected from natural populations of Kyrgyzstan—were studied by liquid chromatography with high‐resolution mass spectrometry (LC‐HRMS).
Chernonosov, Alexander A., Erst, Andrey S., Kostikova, Vera A., Kulikovskiy, Maxim S., Maltseva, Svetlana Yu., Petrova, Natalia V., Wang, Wei   +6 more
core   +2 more sources

Studies on Regioselective Binding Mode of Steroid Molecules in Homology Modeled Cytochrome P450-2C11 [PDF]

, 2009
In this study, we investigated the regioselective binding mode of steroid molecules and structure requirements for steroid molecules for 16[alpha]-hydroxylation by Cytochrome P450-2C11.
Eiichi Akaho, Hamed I. Ali, Hukihisa Fujita, Morio Yamada   +3 more
core   +1 more source

Extraction, Isolation, and Purification of Furanocoumarins from Invasive Heracleum sosnowskyi

Separations
Heracleum sosnowskyi Manden. (Sosnowsky’s hogweed), originally introduced to Central and Eastern Europe as a fodder crop, has become a highly invasive species due to its ecological adaptability, high reproductive capacity, and efficient seed dispersal ...
Vida Vickackaite, Karina Pilaityte, Vilius Poskus   +2 more
doaj   +1 more source

PharmVar GeneFocus: CYP2A6

Clinical Pharmacology &Therapeutics, Volume 116, Issue 4, Page 948-962, October 2024.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the human CYP2A gene locus containing the highly polymorphic CYP2A6 gene. CYP2A6 plays a role in the metabolism of nicotine and various drugs. Thus, genetic variation can substantially contribute to the function of this enzyme and associated efficacy and safety.
Alec W.R. Langlois, Meghan J. Chenoweth, David Twesigomwe, Giada Scantamburlo, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Charity Nofziger, Rachel F. Tyndale, Andrea Gaedigk   +9 more
wiley   +1 more source

Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis

Environmental Toxicology, Volume 39, Issue 9, Page 4333-4346, September 2024.
Abstract Plants provide a wide array of compounds that can be explored for potential anticancer properties. Siphonochilone, a furanoterpene that represents one of the main components of the African plant Siphonochilus aethiopicus, shows numerous health benefits. However, to date, its antiproliferative properties have not been tested.
Alba Ortigosa‐Palomo, David Fuentes‐Ríos, Francisco Quiñonero, Consolación Melguizo, Raul Ortiz, Juan M. López‐Romero, Jose Prados   +6 more
wiley   +1 more source

Natural Coumarins: QSTR Approaches Regarding Their Genotoxicity [PDF]

, 2015
The 18th International Electronic Conference on Synthetic Organic Chemistry session Computational ChemistryCoumarins are a group of phytochemicals with multiple applications in different fields, such as food and medicine. Many of their benefits are based
Abreu, Orlando, Guardado Yordi, Estela, Matos, Maria João Correia Pinto Carvalho de, Molina, Enrique, Santana Penín, María Lourdes, Uriarte Villares, Eugenio   +5 more
core   +1 more source

Phototherapy for the treatment of cutaneous graft‐versus‐host disease: A systematic review

Photodermatology, Photoimmunology &Photomedicine, Volume 40, Issue 5, September 2024.
Abstract Background Cutaneous graft‐versus‐host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation. Phototherapy has been used to treat cutaneous GVHD, but data on its safety and efficacy are sparse. Aim Review the current medical literature regarding the efficacy, dosing, and safety of various types of ...
Tahel Fachler‐Sharp, Inbar Kobal, Sivan Sheffer‐Levi, Adiel Cohen, Ayal Hassidim, Vered Molho‐Pessach, Rony Shreberk‐Hassidim   +6 more
wiley   +1 more source

Deuterated Alkyl Sulfonium Salt Reagents; Importance of H/D Exchange Methods in Drug Discovery

ChemMedChem, Volume 19, Issue 16, August 19, 2024.
Recently, deuterated drugs have been highlighted as a new modality, and H/D exchange reactions are powerful and straightforward synthetic tools. We have successfully established a novel concept to diversify deuterium drug discovery using dn‐alkylation reagents (dn‐alkyl diphenylsulfonium salts) with excellent D contents and perfect site selectivity ...
Riku Ogasahara, Kazuho Ban, Miyu Mae, Shuji Akai, Yoshinari Sawama   +4 more
wiley   +1 more source

Methoxsalen loaded chitosan coated microemulsion for effective treatment of psoriasis [PDF]

, 2011
Methoxsalen has been used for the treatment of psoriasis. In order to develop alternative formulations for the topical administration of methoxsalen, chitosan coated microemulsion were evaluated as delivery vehicle.
Behera, Jitendra, Chadoker, Anoop, Keservani, Raj K., Tripathi, Meenendra, Yadav, Arvind   +4 more
core   +1 more source