Results 51 to 60 of about 1,920 (175)

PharmVar GeneFocus: CYP2A6

Clinical Pharmacology &Therapeutics, Volume 116, Issue 4, Page 948-962, October 2024.
The Pharmacogene Variation Consortium (PharmVar) provides nomenclature for the human CYP2A gene locus containing the highly polymorphic CYP2A6 gene. CYP2A6 plays a role in the metabolism of nicotine and various drugs. Thus, genetic variation can substantially contribute to the function of this enzyme and associated efficacy and safety.
Alec W.R. Langlois, Meghan J. Chenoweth, David Twesigomwe, Giada Scantamburlo, Michelle Whirl‐Carrillo, Katrin Sangkuhl, Teri E. Klein, Charity Nofziger, Rachel F. Tyndale, Andrea Gaedigk   +9 more
wiley   +1 more source

Evaluation of cytotoxic effect of siphonochilone from African ginger: an in vitro analysis

Environmental Toxicology, Volume 39, Issue 9, Page 4333-4346, September 2024.
Abstract Plants provide a wide array of compounds that can be explored for potential anticancer properties. Siphonochilone, a furanoterpene that represents one of the main components of the African plant Siphonochilus aethiopicus, shows numerous health benefits. However, to date, its antiproliferative properties have not been tested.
Alba Ortigosa‐Palomo, David Fuentes‐Ríos, Francisco Quiñonero, Consolación Melguizo, Raul Ortiz, Juan M. López‐Romero, Jose Prados   +6 more
wiley   +1 more source

Phototherapy for the treatment of cutaneous graft‐versus‐host disease: A systematic review

Photodermatology, Photoimmunology &Photomedicine, Volume 40, Issue 5, September 2024.
Abstract Background Cutaneous graft‐versus‐host disease (GVHD) is a common complication of allogeneic hematopoietic stem cell transplantation. Phototherapy has been used to treat cutaneous GVHD, but data on its safety and efficacy are sparse. Aim Review the current medical literature regarding the efficacy, dosing, and safety of various types of ...
Tahel Fachler‐Sharp, Inbar Kobal, Sivan Sheffer‐Levi, Adiel Cohen, Ayal Hassidim, Vered Molho‐Pessach, Rony Shreberk‐Hassidim   +6 more
wiley   +1 more source

Deuterated Alkyl Sulfonium Salt Reagents; Importance of H/D Exchange Methods in Drug Discovery

ChemMedChem, Volume 19, Issue 16, August 19, 2024.
Recently, deuterated drugs have been highlighted as a new modality, and H/D exchange reactions are powerful and straightforward synthetic tools. We have successfully established a novel concept to diversify deuterium drug discovery using dn‐alkylation reagents (dn‐alkyl diphenylsulfonium salts) with excellent D contents and perfect site selectivity ...
Riku Ogasahara, Kazuho Ban, Miyu Mae, Shuji Akai, Yoshinari Sawama   +4 more
wiley   +1 more source

Primary cutaneous plasmacytosis successfully treated with topical corticosteroids and psoralen plus ultraviolet A: A case report

Clinical Case Reports, Volume 12, Issue 3, March 2024.
Key clinical message We present a case of primary cutaneous plasmacytosis without systemic involvement. The patient received topical corticosteroids and psoralen plus ultraviolet A therapy, showing significant improvement. Continuous monitoring is underway despite the rarity of systemic manifestations.
Thanyathorn Nuchanatanon, Settanan Plangsiri, Teerapong Rattananukrom   +2 more
wiley   +1 more source

Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, in Japanese patients with moderate to severe plaque, erythrodermic, or generalized pustular psoriasis: Efficacy and safety results from an open‐label, phase 3 trial

The Journal of Dermatology, Volume 51, Issue 3, Page 365-379, March 2024.
Abstract Deucravacitinib, an oral, selective, allosteric tyrosine kinase 2 inhibitor, is approved in Japan for adult patients with plaque (PP), generalized pustular (GPP), and erythrodermic (EP) psoriasis who have had an inadequate response to conventional systemic therapies.
Shinichi Imafuku, Yukari Okubo, Yayoi Tada, Mamitaro Ohtsuki, Elizabeth Colston, Andrew Napoli, Yanqiu Shao, Subhashis Banerjee, Akimichi Morita   +8 more
wiley   +1 more source

Phenolic Compounds of Fresh Roots and Rhizomes of Garden Angelica Angelica Archangelica L.

International Journal of Secondary Metabolite, 2014
Because in the process of drying and storage of plant materials is a change of genuine compounds, we studied the content of phenolic compounds in freshly drawn angelica roots and rhizomes of the drug Angelica archangelica L. samples had been taken on the
R. M. BASHIROVA, А. G. MUSTAFIN1, E. G. GALKIN, F. F. ABDULLAEV   +3 more
doaj   +2 more sources

Time‐dependent change of T cell receptor clonality: From large plaque parapsoriasis to early mycosis fungoides

Skin Research and Technology, Volume 30, Issue 8, August 2024.
Munenari Itoh, Akihiko Asahina, Yoshimasa Nobeyama   +2 more
wiley   +1 more source

Malignant Melanoma in Patients Treated for Psoriasis with Methoxsalen (Psoralen) and Ultraviolet A Radiation (PUVA) [PDF]

, 1997
Robert S. Stern, Khanh T. Nichols, Liisa Väkevä   +2 more
openalex   +1 more source

Phenolic Compounds of Fresh Roots and Rhizomes of Garden Angelica Angelica Archangelica L.

International Journal of Secondary Metabolite, 2016
Because in the process of drying and storage of plant materials is a change of genuine compounds, we studied the content of phenolic compounds in freshly drawn angelica roots and rhizomes of the drug Angelica archangelica L. samples had been taken on the
R. M. BASHIROVA, А. G. MUSTAFIN1, E. G. GALKIN, F. F. ABDULLAEV   +3 more
doaj