Results 101 to 110 of about 917,353 (421)

Sulforaphane Suppressed Stemness Characters of Lung Adenocarcinoma Stem Cells by Down-regulating Methylation of miR-200c Promoter

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the effect of sulforaphane (SFN) on the proliferation and self-renewal of lung cancer stem cells and its regulatory mechanism.
LIANG Guangxia, QIN Xituan, XIE Wei, XIE Youke   +3 more
doaj   +1 more source

The Role of Cytosine Methylation on Charge Transport through a DNA Strand [PDF]

J Chem Phys. 2015 Sep 7;143(9):094306, 2017
Cytosine methylation has been found to play a crucial role in various biological processes, including a number of human diseases. The detection of this small modification remains challenging. In this work, we computationally explore the possibility of detecting methylated DNA strands through direct electrical conductance measurements.
arxiv   +1 more source

Intragenic DNA methylation: implications of this epigenetic mechanism for cancer research [PDF]

, 2011
Epigenetics is the study of all mechanisms that regulate gene transcription and genome stability that are maintained throughout the cell division, but do not include the DNA sequence itself.
A Hellman, A Zemach, AK Maunakea, AP Bird, C Tufarelli, D Aran, D Takai, D Zilberman, E Hodges, E Segal, EN Gal-Yam, H Cedar, H Han, HH Ng, J M Flanagan, JA Yoder, JD Lieb, JF Smith, JK Choi, JK Choi, JM Flanagan, JM Flanagan, JT Huff, K Appleton, K Flower, KR Blahnik, L Nanty, L Wild, M Lorincz, M Weber, MA Hahn, MA Hahn, MG Guenther, MJ Carrozza, MM Suzuki, MP Ball, N Shenker, PA Jones, R Appanah, RD Hawkins, S Feng, S Fu, TA Rauch, TE Fandy, V Rishi, VM Komashko, VM Komashko, WA Schulz, X Zhang, Y Li, YJ Shann   +50 more
core   +1 more source

Unlocking the potential of tumor‐derived DNA in urine for cancer detection: methodological challenges and opportunities

Molecular Oncology, EarlyView.
Urine is a rich source of biomarkers for cancer detection. Tumor‐derived material is released into the bloodstream and transported to the urine. Urine can easily be collected from individuals, allowing non‐invasive cancer detection. This review discusses the rationale behind urine‐based cancer detection and its potential for cancer diagnostics ...
Birgit M. M. Wever, Renske D. M. Steenbergen   +1 more
wiley   +1 more source

Hypermethylation of the TPEF/HPP1 Gene in Primary, Metastatic Colorectal Cancers

Neoplasia: An International Journal for Oncology Research, 2005
The role of promoter methylation in the process of cancer cell metastasis has not yet been studied. Recently, methylation of the TPEF (transmembrane protein containing epidermal growth factor, follistatin domain) gene was reported in human colon, gastric,
Matthias P.A. Ebert, Suzanne H. Mooney, Lori Tonnes-Priddy, Joe Lograsso, Juliane Hoffmann, Jie Chent, Christoph Rocken, Hans-Ulrich Schulz, Peter Malfertheiner, Catherine Lofton-Day   +9 more
doaj   +1 more source

UV photodissociation of methyl bromide and methyl bromide cation studied by velocity map imaging [PDF]

Journal of Chemical Physics 130 (2009) 034304, 2009
We employ the velocity map imaging technique to measure kinetic energy and angular distributions of state selected CH3 (v2=0,1,2,3) and Br (2P3/2,2P1/2) photofragments produced by methyl bromide photolysis at 215.9 nm. These results show unambiguously that the Br and Br* forming channels result in different vibrational excitation of the umbrella mode ...
arxiv   +1 more source

Clinical applications of next‐generation sequencing‐based ctDNA analyses in breast cancer: defining treatment targets and dynamic changes during disease progression

Molecular Oncology, EarlyView.
Circulating tumor DNA (ctDNA) offers a possibility for different applications in early and late stage breast cancer management. In early breast cancer tumor informed approaches are increasingly used for detecting molecular residual disease (MRD) and early recurrence. In advanced stage, ctDNA provides a possibility for monitoring disease progression and
Eva Valentina Klocker, Samantha Hasenleithner, Rupert Bartsch, Simon P. Gampenrieder, Daniel Egle, Christian F. Singer, Gabriel Rinnerthaler, Michael Hubalek, Katja Schmitz, Zsuzsanna Bago‐Horvath, Andreas Petzer, Sonja Heibl, Ellen Heitzer, Marija Balic, Michael Gnant   +14 more
wiley   +1 more source

The role of m6A RNA methylation in human cancer

Molecular Cancer, 2019
N6-methyladenosine (m6A) is identified as the most common, abundant and conserved internal transcriptional modification, especially within eukaryotic messenger RNAs (mRNAs).
Xiaoyu Chen, Jing Zhang, Jinshui Zhu
semanticscholar   +1 more source

Integrative analysis of circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients: a comprehensive approach

Molecular Oncology, EarlyView.
This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou, Argyro Roumeliotou, Evangelia Pantazaka, Athanasios‐Nasir Shaukat, Athina Christopoulou, Angelos Koutras, Foteinos‐Ioannis Dimitrakopoulos, Vassilis Georgoulias, Anastasia Xagara, Evangelia Chantzara, Fillipos Koinis, Athanasios Kotsakis, Constantinos Stathopoulos, Galatea Kallergi   +13 more
wiley   +1 more source

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Science, 2017
Positives and negatives of methylated CpG When the DNA bases cytosine and guanine are next to each other, a methyl group is generally added to the pyrimidine, generating a mCpG dinucleotide.
Yimeng Yin, E. Morgunova, A. Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, P. Das, Teemu Kivioja, Kashyap Dave, F. Zhong, K. Nitta, Minna Taipale, A. Popov, P. Ginno, Silvia Domcke, Jian Yan, D. Schübeler, C. Vinson, J. Taipale   +18 more
semanticscholar   +1 more source