Results 101 to 110 of about 1,050,423 (388)

Ageing And Cancer As Diseases Of Epigenesis [PDF]

, 2009
Cancer and ageing are often said to be diseases of development. During the past fifty years, the genetic components of cancer and ageing have been intensely investigated since development, itself, was seen to be an epiphenomenon of the genome.
Gilbert, Scott F.
core   +2 more sources

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

Correlation between MGMT methylation and the efficacy of bevacizumab in high-grade glioma

Frontiers in Oncology
PurposeThe aim of this study is to investigate whether the therapeutic efficacy of bevacizumab (BEV) in the treatment of high-grade glioma (HGG) is associated with the methylation status of O6-methylguanine-DNA methyltransferase (MGMT) on the basis of ...
Chengrui Yan, Xuexue Bai, Chao Wu, Wenbin Ma, Ming Feng   +4 more
doaj   +1 more source

Early-Onset Schizophrenia: A Special Phenotype of the Disease Characterized by Increased MTHFR Polymorphisms and Aggravating Symptoms

Neuropsychiatric Disease and Treatment, 2021
Lin Wan, Jing Wei Department of Psychological Medicine, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, People’s Republic of ChinaCorrespondence: Jing WeiDepartment of Psychological ...
Wan L, Wei J
doaj  

Differentially methylated CpG sites associated with the high-risk group of prostate cancer

Journal of Integrative Bioinformatics, 2020
Prostate cancer (PC) is one of the most common and socially significant oncological diseases among men. Bioinformatic analysis of omics data allows identifying molecular genetic changes associated with the disease development, as well as markers of ...
Kobelyatskaya Anastasiya, Pudova Elena, Fedorova Maria, Nyushko Kirill, Alekseev Boris, Kaprin Andrey, Trofimov Dmitry, Sukhikh Gennady, Snezhkina Anastasia, Krasnov George, Razin Sergey, Kudryavtseva Anna   +11 more
doaj   +1 more source

The Studies of Prognostic Factors and the Genetic Polymorphism of Methylenetetrahydrofolate Reductase C667T in Thymic Epithelial Tumors

Frontiers in Oncology, 2022
ObjectiveTo describe the clinical features of a cohort of patients with thymic epithelial tumors (TETs) and to analyze their prognostic factors. In particular, we investigated the correlation between the genetic polymorphism of methylenetetrahydrofolate ...
Miaolong Yan, Miaolong Yan, Jiayuan Wu, Min Xue, Min Xue, Juanfen Mo, Li Zheng, Jun Zhang, Zhenzhen Gao, Yi Bao, Yi Bao   +10 more
doaj   +1 more source

Examination of Methylation Sites for Forensic Age Determination from Semen [PDF]

, 2018
Methylation Sensitive High-Resolution Melt (MS-HRM) is based on quantitating the melt curve from an experimental sample against a standard of known methylation levels.
Renwick, Christian, Seashols-Williams, Sarah J.   +1 more
core   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Detection of WNT7A Methylation in Peripheral Blood of NSCLC Patients and Its Diagnostic Value

Zhongliu Fangzhi Yanjiu, 2019
Objective To explore the relation between WNT7A methylation and clinical factors of NSCLC patients. Methods We selected 120 NSCLC patients as NSCLC group and 120 healthy people as control group.
XU Yao, ZHANG Chang, PENG Li, ZHANG Junxia   +3 more
doaj   +1 more source

CpG Island Methylation of Suppressor of Cytokine Signaling-1 Gene Induced by HCV Is Associated With HCV-Related Hepatocellular Carcinoma

Frontiers in Microbiology, 2022
Suppressor of cytokine signaling 1 (SOCS-1) is implicated in both virus infection and carcinogenesis. This study investigated the role of HCV infection on SOCS-1 in normal and HCV-infected tissues and revealed a possible mechanism underlying HCV-induced ...
Miao Liu, Lingyao Du, Xing Cheng, Man Yuan, Jin Shang, Jin Shang, Ying Shi, Hailing Yang, Hailing Yang, Hong Tang   +9 more
doaj   +1 more source