Results 21 to 30 of about 1,069,555 (390)

Plants regenerated from tissue culture contain stable epigenome changes in rice. [PDF]

, 2013
Most transgenic crops are produced through tissue culture. The impact of utilizing such methods on the plant epigenome is poorly understood. Here we generated whole-genome, single-nucleotide resolution maps of DNA methylation in several regenerated rice ...
Bellizzi, Maria, Ding, Bo, Feng, Suhua, Jacobsen, Steven E, Meyers, Blake C, Pellegrini, Matteo, Simon, Stacey A, Stroud, Hume, Wang, Guo-Liang   +8 more
core   +2 more sources

The Landscape of Iron Metabolism-Related and Methylated Genes in the Prognosis Prediction of Clear Cell Renal Cell Carcinoma

Frontiers in Oncology, 2020
Background: Clear cell renal cell carcinoma (ccRCC) is characteristics of resistance to chemotherapy and radiotherapy. The prognosis of ccRCC was dismay with immense diversity. Iron metabolism disturbance is a common phenomenon in ccRCC.
Yanhua Mou, Yanhua Mou, Yao Zhang, Jinchun Wu, Busheng Hu, Chunfang Zhang, Chaojun Duan, Chaojun Duan, Bin Li, Bin Li   +9 more
doaj   +1 more source

Current Advances in N6-Methyladenosine Methylation Modification During Bladder Cancer

Frontiers in Genetics, 2022
N6-methyladenosine (m6A) is a dynamic, reversible post-transcriptional modification, and the most common internal modification of eukaryotic messenger RNA (mRNA).
Qiang Liu
doaj   +1 more source

In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children. [PDF]

, 2019
BackgroundMaternal smoking during pregnancy is a risk factor for chronic disease later in life and has been associated with variability of DNA methylation at specific cytosine-phosphate-guanine (CpG) loci.
Barker, Beach, Beamer, Best, Cardenas, Chhabra, Cunningham, DiFranza, Galanter, Gibbs, Gilliland, Gilliland, Gilliland, Hanieh, Harb, Hu, Jaakkola, Jauniaux, Joubert, Joubert, Küpers, Lara, Morales, Oh, Perreira, Pickett, Rahmani, Reese, Reese, Rehan, Richiardi, Richmond, Richmond, Sharma, Shorey-Kendrick, Stick, Stocks, Tong, Upton, van der Laan, Vanderweele, VanderWeele, Waterland, Wongtrakool, Wu, Zeilinger, Zhang, Zhong   +47 more
core   +1 more source

Differential Expression of HOX Genes in Mesenchymal Stem Cells from Osteoarthritic Patients Is Independent of Their Promoter Methylation

Cells, 2018
Skeletogenesis, remodeling, and maintenance in adult tissues are regulated by sequential activation of genes coding for specific transcription factors.
Arkaitz Mucientes, Eva Herranz, Enrique Moro, Cristina Lajas, Gloria Candelas, Benjamín Fernández-Gutiérrez, José Ramón Lamas   +6 more
doaj   +1 more source

Research Progress on Epigenetics of Diabetic Cardiomyopathy in Type 2 Diabetes

Frontiers in Cell and Developmental Biology, 2021
Diabetic cardiomyopathy (DCM) is characterized by diastolic relaxation abnormalities in its initial stages and by clinical heart failure (HF) without dyslipidemia, hypertension, and coronary artery disease in its last stages.
Jianxin Deng, Yunxiu Liao, Jianpin Liu, Wenjuan Liu, Dewen Yan   +4 more
doaj   +1 more source

DNA methylation GrimAge strongly predicts lifespan and healthspan

Aging, 2019
It was unknown whether plasma protein levels can be estimated based on DNA methylation (DNAm) levels, and if so, how the resulting surrogates can be consolidated into a powerful predictor of lifespan.
A. Lu, Austin Quach, James G. Wilson, A. Reiner, A. Aviv, K. Raj, L. Hou, A. Baccarelli, Yun Li, J. Stewart, E. Whitsel, T. Assimes, L. Ferrucci, S. Horvath   +13 more
semanticscholar   +1 more source

Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]

, 2018
BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas, A Crudo, A Gavrila, Andrea A. Baccarelli, Andres Cardenas, Augusto A. Litonjua, C Lesseur, C Newton-Cheh, CA Sandman, CA Sandman, CE Boeke, CS Mantzoros, CV Breton, DA Kertes, Dawn L. DeMeo, DM O’Connor, E Baibazarova, E Marinoni, E Oken, E Oken, E Salvi, Emily Oken, ER Gibney, FI Milagro, Fu-Ying Tian, H Masuzaki, I Melzner, IC McMillen, Janet W. Rich-Edwards, JD Swinny, JJ Bonfiglio, JM Sheen, JT Smith, JW Rich-Edwards, K Barber, K Boekelheide, L Bouchard, LE Reinius, M Graff, M Urbanek, Mao-Meng Tiao, Marie-France Hivert, Matthew W. Gillman, MC García-Cardona, MC Sugden, MH Fasting, MW Gillman, MW Logue, N Alexander, N Sonenberg, ND Saenen, NJ Westphal, PD Wadhwa, PJ Trainer, R Kadakia, RL Emanuel, RS Ahima, RX Ren, S Pauwels, S Ramchandani, SA Obermann-Borst, Sheryl L. Rifas-Shiman, SJ McClennen, SJ McClennen, SY Moon, TA Dardeno, TC Martin, TJ Peters, VG Moisiadis, Y Chen, YC Chen, YD Salinas, Zari Dastani   +72 more
core   +1 more source

Uniformity of Peptide Release Is Maintained by Methylation of Release Factors

Cell Reports, 2016
Termination of protein synthesis on the ribosome is catalyzed by release factors (RFs), which share a conserved glycine-glycine-glutamine (GGQ) motif.
William E. Pierson, Eric D. Hoffer, Hannah E. Keedy, Carrie L. Simms, Christine M. Dunham, Hani S. Zaher   +5 more
doaj   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources