Results 21 to 30 of about 641,368 (381)

Whole-Genome Methylation Study of Congenital Lung Malformations in Children

Frontiers in Oncology, 2021
Background and ObjectivesThe treatment of asymptomatic patients with congenital pulmonary malformations (CPMs) remains controversial, partially because the relationship between congenital lung malformations and malignancy is still undefined.
Sara Patrizi, Federica Pederiva, Adamo Pio d’Adamo, Adamo Pio d’Adamo   +3 more
doaj   +1 more source

DNA methylation heterogeneity induced by collaborations between enhancers [PDF]

Journal of Computational Biology, 2020, 2020
During mammalian embryo development, reprogramming of DNA methylation plays important roles in the erasure of parental epigenetic memory and the establishment of na\"{i}ve pluripogent cells. Multiple enzymes that regulate the processes of methylation and demethylation work together to shape the pattern of genome-scale DNA methylation and guid the ...
arxiv   +1 more source

Methyl eucomate [PDF]

Acta Crystallographica Section E Structure Reports Online, 2008
THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND [SYSTEMATIC NAME: methyl 3-carboxy-3-hydr-oxy-3-(4-hydroxy-benz-yl)propanoate], C(12)H(14)O(6), is stabilized by inter-molecular O-H⋯O and C-H⋯O hydrogen bonds. The mol-ecules are arranged in layers, parallel to (001), which are inter-connected by the O-H⋯O hydrogen bonds.
Linglin Li, Guang-Xiong Zhou, Ren-Wang Jiang   +2 more
openaire   +3 more sources

Imprinted Genes Impact Upon Beta Cell Function in the Current (and Potentially Next) Generation

Frontiers in Endocrinology, 2021
Beta cell failure lies at the centre of the aetiology and pathogenesis of type 2 diabetes and the epigenetic control of the expression of critical beta cell genes appears to play a major role in this decline.
Chelsie Villanueva-Hayes, Steven J. Millership   +1 more
doaj   +1 more source

Decreased MEF2A Expression Regulated by Its Enhancer Methylation Inhibits Autophagy and May Play an Important Role in the Progression of Alzheimer’s Disease

Frontiers in Neuroscience, 2021
Alzheimer’s disease (AD) is a neurodegenerative disease characterized by amyloid plaques and neurofibrillary tangles which significantly affects people’s life quality. Recently, AD has been found to be closely related to autophagy.
Hui Li, Feng Wang, Xuqi Guo, Yugang Jiang   +3 more
doaj   +1 more source

DNA methylation age of human tissues and cell types

Genome Biology, 2013
It is not yet known whether DNA methylation levels can be used to accurately predict age across a broad spectrum of human tissues and cell types, nor whether the resulting age prediction is a biologically meaningful measure.
S. Horvath
semanticscholar   +1 more source

Polyphenol-Rich Aronia melanocarpa Juice Consumption Affects LINE-1 DNA Methylation in Peripheral Blood Leukocytes in Dyslipidemic Women

Frontiers in Nutrition, 2021
Cardiovascular disease (CVD) is associated with alterations in DNA methylation and polyunsaturated fatty acid (PUFA) profile, both modulated by dietary polyphenols.
Ljiljana Stojković, Manja Zec, Manja Zec, Maja Zivkovic, Maja Bundalo, Maja Bundalo, Maja Bošković, Marija Glibetić, Aleksandra Stankovic   +8 more
doaj   +1 more source

Bismark: a flexible aligner and methylation caller for Bisulfite-Seq applications

Bioinform., 2011
Summary: A combination of bisulfite treatment of DNA and high-throughput sequencing (BS-Seq) can capture a snapshot of a cell's epigenomic state by revealing its genome-wide cytosine methylation at single base resolution.
Felix Krueger, Simon R. Andrews
semanticscholar   +1 more source

Sarcoma classification by DNA methylation profiling

Nature Communications, 2021
Sarcomas are malignant soft tissue and bone tumours affecting adults, adolescents and children. They represent a morphologically heterogeneous class of tumours and some entities lack defining histopathological features.
C. Koelsche, D. Schrimpf, D. Stichel, M. Sill, F. Sahm, D. Reuss, Mirjam Blattner, Barbara C. Worst, C. Heilig, K. Beck, P. Horák, S. Kreutzfeldt, Elke Paff, S. Stark, P. Johann, F. Selt, J. Ecker, D. Sturm, K. Pajtler, A. Reinhardt, A. Wefers, P. Sievers, A. Ebrahimi, A. Suwala, F. Fernández-Klett, B. Casalini, A. Korshunov, V. Hovestadt, F. Kommoss, M. Kriegsmann, M. Schick, M. Bewerunge-Hudler, T. Milde, O. Witt, A. Kulozik, M. Kool, L. Romero-Pérez, T. G. Grünewald, T. Kirchner, W. Wick, M. Plattén, A. Unterberg, M. Uhl, A. Abdollahi, J. Debus, B. Lehner, C. Thomas, M. Hasselblatt, W. Paulus, C. Hartmann, O. Staszewski, M. Prinz, J. Hench, S. Frank, Y. Versleijen-Jonkers, M. Weidema, T. Mentzel, K. Griewank, E. de Álava, Juan Díaz Martín, M. I. Gastearena, K. Chang, S. Low, Adrián Cuevas-Bourdier, M. Mittelbronn, M. Mynarek, S. Rutkowski, U. Schüller, V. Mautner, J. Schittenhelm, J. Serrano, M. Snuderl, R. Büttner, T. Klingebiel, R. Buslei, M. Gessler, P. Wesseling, W. Dinjens, S. Brandner, Z. Jaunmuktane, Iben Lyskjær, P. Schirmacher, A. Stenzinger, B. Brors, H. Glimm, C. Heining, Ò. M. Tirado, Miguel Sáinz-Jaspeado, J. Mora, J. Alonso, X. G. del Muro, S. Moran, M. Esteller, J. Benhamida, M. Ladanyi, E. Wardelmann, C. Antonescu, A. Flanagan, U. Dirksen, P. Hohenberger, D. Baumhoer, W. Hartmann, C. Vokuhl, U. Flucke, I. Petersen, G. Mechtersheimer, D. Capper, David T. W. Jones, S. Fröhling, S. Pfister, A. von Deimling   +110 more
semanticscholar   +1 more source

The Epigenetics of Glioma Stem Cells: A Brief Overview

Frontiers in Oncology, 2020
Glioma stem cells (GSCs) are crucial in the formation, perpetuation and recurrence of glioblastomas (GBs) due to their self-renewal and proliferation properties.
Luis M. Valor, Irati Hervás-Corpión
doaj   +1 more source