Results 31 to 40 of about 1,050,423 (388)
SUVH1, a Su(var)3-9 family member, promotes the expression of genes targeted by DNA methylation. [PDF]
, 2015 Transposable elements are found throughout the genomes of all organisms. Repressive marks such as DNA methylation and histone H3 lysine 9 (H3K9) methylation silence these elements and maintain genome integrity.
Chen, Xuemei +6 more
core +2 more sources
DNA methylation-based classification of central nervous system tumours
Nature, 2018 Accurate pathological diagnosis is crucial for optimal management of patients with cancer. For the approximately 100 known tumour types of the central nervous system, standardization of the diagnostic process has been shown to be particularly challenging—
D. Capper +142 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2021 Autism spectrum disorder (ASD) is a complex disorder that is underpinned by numerous dysregulated biological pathways, including pathways that affect mitochondrial function. Epigenetic mechanisms contribute to this dysregulation and DNA methylation is an
Sophia Bam +3 more
doaj +1 more source
Immortalization of T-cells is accompanied by gradual changes in CpG methylation resulting in a profile resembling a subset of T-cell leukemias [PDF]
, 2014 We have previously described gene expression changes during spontaneous immortalization of T-cells, thereby identifying cellular processes important for cell growth crisis escape and unlimited proliferation. Here, we analyze the same model to investigate
Borssén, Magnus +10 more
core +1 more source
Acta Crystallographica Section E Structure Reports Online, 2009 THE CRYSTAL STRUCTURE OF THE TITLE COMPOUND (SYSTEMATIC NAME: methyl 3,4,5-trihydroxy-benzoate), C(8)H(8)O(5), is composed of essentially planar mol-ecules [maximum departures from the mean carbon and oxygen skeleton plane of 0.0348 (10) Å]. The H atoms of the three hydroxyl groups, which function as hydrogen-bond donors and acceptors simultaneously ...
Silvina Pagola, Deborah Bebout
openaire +3 more sources
Frontiers in Oncology, 2020 Background: Clear cell renal cell carcinoma (ccRCC) is characteristics of resistance to chemotherapy and radiotherapy. The prognosis of ccRCC was dismay with immense diversity. Iron metabolism disturbance is a common phenomenon in ccRCC.
Yanhua Mou +9 more
doaj +1 more source
Current Advances in N6-Methyladenosine Methylation Modification During Bladder Cancer
Frontiers in Genetics, 2022 N6-methyladenosine (m6A) is a dynamic, reversible post-transcriptional modification, and the most common internal modification of eukaryotic messenger RNA (mRNA).
Qiang Liu
doaj +1 more source
Plants regenerated from tissue culture contain stable epigenome changes in rice. [PDF]
, 2013 Most transgenic crops are produced through tissue culture. The impact of utilizing such methods on the plant epigenome is poorly understood. Here we generated whole-genome, single-nucleotide resolution maps of DNA methylation in several regenerated rice ...
Bellizzi, Maria +8 more
core +2 more sources
Maternal corticotropin-releasing hormone is associated with LEP DNA methylation at birth and in childhood: an epigenome-wide study in Project Viva [PDF]
, 2018 BackgroundCorticotropin-releasing hormone (CRH) plays a central role in regulating the secretion of cortisol which controls a wide range of biological processes. Fetuses overexposed to cortisol have increased risks of disease in later life.
A Cardenas +72 more
core +1 more source
Cells, 2018 Skeletogenesis, remodeling, and maintenance in adult tissues are regulated by sequential activation of genes coding for specific transcription factors.
Arkaitz Mucientes +6 more
doaj +1 more source