Results 31 to 40 of about 881,260 (340)

Race-specific alterations in DNA methylation among middle-aged African Americans and Whites with metabolic syndrome

Epigenetics, 2020
Metabolic syndrome (MetS) is a cluster of cardiometabolic risk factors for all-cause mortality, cardiovascular disease, and cancer. Identifying epigenetic alterations associated with MetS in African Americans (AAs) and Whites may provide insight into ...
Kumaraswamy Naidu Chitrala, Dena G. Hernandez, Michael A. Nalls, Nicolle A. Mode, Alan B. Zonderman, Ngozi Ezike, Michele K. Evans   +6 more
doaj   +1 more source

Mechanisms of impaired expression of p53-responsive microRNA genes in diffuse B-large cell lymphoma

Успехи молекулярной онкологии, 2023
Introduction. A more in-depth description of molecular events that disrupt the functioning of the p53 signaling pathway is important for understanding the mechanisms of formation and progression of diffuse B-large cell lymphoma (DCCL), as well as its ...
E. N. Voropaeva, T. I. Pospelova, M. I. Churkina, A. A. Gurazheva, O. V. Berezina, V. N. Maksimov   +5 more
doaj   +1 more source

In utero tobacco smoke exposure, DNA methylation, and asthma in Latino children. [PDF]

, 2019
BackgroundMaternal smoking during pregnancy is a risk factor for chronic disease later in life and has been associated with variability of DNA methylation at specific cytosine-phosphate-guanine (CpG) loci.
Barker, Beach, Beamer, Best, Cardenas, Chhabra, Cunningham, DiFranza, Galanter, Gibbs, Gilliland, Gilliland, Gilliland, Hanieh, Harb, Hu, Jaakkola, Jauniaux, Joubert, Joubert, Küpers, Lara, Morales, Oh, Perreira, Pickett, Rahmani, Reese, Reese, Rehan, Richiardi, Richmond, Richmond, Sharma, Shorey-Kendrick, Stick, Stocks, Tong, Upton, van der Laan, Vanderweele, VanderWeele, Waterland, Wongtrakool, Wu, Zeilinger, Zhang, Zhong   +47 more
core   +1 more source

Promoter aberrant methylation status of ADRA1A is associated with hepatocellular carcinoma

Epigenetics, 2020
The aim of our study was to explore the relationship between the methylation status of the alpha-1A adrenergic receptor (ADRA1A) gene and hepatocellular carcinoma (HCC).
Guoqiao Chen, Xiaoxiao Fan, Yirun Li, Lifeng He, Shanjuan Wang, Yili Dai, Cui Bin, Daizhan Zhou, Hui Lin   +8 more
doaj   +1 more source

DNA methylation and DNA methyltransferases [PDF]

, 2017
The prevailing views as to the form, function, and regulation of genomic methylation patterns have their origin many years in the past, at a time when the structure of the mammalian genome was only dimly perceived, when the number of protein-encoding ...
Bestor, Timothy H, Boulard, Mathieu, Edwards, John R, Yarychkivska, Olya   +3 more
core   +3 more sources

Plant-RRBS, a bisulfite and next-generation sequencing-based methylome profiling method enriching for coverage of cytosine positions [PDF]

, 2017
Background: Cytosine methylation in plant genomes is important for the regulation of gene transcription and transposon activity. Genome-wide methylomes are studied upon mutation of the DNA methyltransferases, adaptation to environmental stresses or ...
A Akalin, A Meissner, A Verkest, AJ Bewick, AR Elhamamsy, AR Quinlan, B Langmead, Bram Slabbinck, C Becker, CA Ibarra, Cindy Martens, D Meng, D Pignatta, EJ Finnegan, F Johannes, Frederik Coppens, G Gremme, H Parkinson, H Saze, H Schöb, H Stroud, H Zhang, H-Q Wang, HJ Xie, International Rice Genome Sequencing Project, J Du, J Yu, JI Gent, K Manning, K Okonechnikov, M Block De, M Block De, M Choi, M Hauben, M Schmidt, Magdalena Woloszynska, Marc De Block, Martin Schmidt, MD Schultz, MG Murray, Michiel Van Bel, Mieke Van Lijsebettens, P Cubas, PF Gugger, PS Schnable, R Lister, RJ Schmitz, SE Jacobsen, SJ Cokus, T-F Hsieh, The Arabidopsis Genome Initiative, TJ Treangen, TP Gurp van, W Guo, X Cao, X Chen, X Li, X Wang, X Zhang, ZD Smith, ZL Liu   +60 more
core   +3 more sources

DNA Methylation Dictates Histone H3K4 Methylation [PDF]

Molecular and Cellular Biology, 2007
Histone lysine methylation and DNA methylation contribute to transcriptional regulation. We have previously shown that acetylated histones are associated with unmethylated DNA and are nearly absent from the methylated DNA regions by using patch-methylated stable episomes in human cells.
Cindy Yen, Okitsu, Chih-Lin, Hsieh
openaire   +2 more sources

The Influence of Methylating Mutations on Acute Myeloid Leukemia: Preliminary Analysis on 56 Patients

Diagnostics, 2020
Acute myeloid leukemia (AML) is a hematologic malignancy characterized by abnormal proliferation and a lack of differentiation of myeloid blasts. Considering the dismal prognosis this disease presents, several efforts have been made to better classify it
Sergiu Pasca, Cristina Turcas, Ancuta Jurj, Patric Teodorescu, Sabina Iluta, Ionut Hotea, Anca Bojan, Cristina Selicean, Bogdan Fetica, Bobe Petrushev, Vlad Moisoiu, Alina-Andreea Zimta, Valentina Sas, Catalin Constantinescu, Mihnea Zdrenghea, Delia Dima, Ciprian Tomuleasa   +16 more
doaj   +1 more source

DNA methylation at the DAT promoter and risk for psychopathology. Intergenerational transmission between school-age youths and their parents in a community sample [PDF]

, 2018
Background: The effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology).
Claudio D’Addario, Claudio D’Addario, Eleonora Marzilli, Esterina Pascale, Giulia Ballarotto, Luca Cerniglia, Renata Tambelli, Silvia Cimino, Walter Adriani, Walter Adriani   +9 more
core   +2 more sources

Fresh Insights Into SLC25A26: Potential New Therapeutic Target for Cancers: A Review

Oncology Reviews
SLC25A26 is the only known human mitochondrial S-adenosylmethionine carrier encoding gene. Recent studies have shown that SLC25A26 is abnormally expressed in some cancers, such as cervical cancer, low-grade glioma, non-small cell lung cancer, and liver ...
Yangheng Xu, Zhisheng Hong, Sheng Yu, Ronghan Huang, Kunqi Li, Ming Li, Sisi Xie, Lvyun Zhu   +7 more
doaj   +1 more source