Possible role of GADD45γ methylation in diffuse large B-cell Lymphoma: Does it affect the progression and tissue involvement? [PDF]
Objective: Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin lymphoma among adults and is characterized by heterogeneous clinical, immunophenotypic, and genetic features.
Barış, İkbal Cansu+10 more
core +2 more sources
From trans-methylation to cytosine methylation: Evolution of the methylation hypothesis of schizophrenia [PDF]
The role of methylation in the history of psychiatry has traversed a storied path. The original trans-methylation hypothesis was proposed at a time when chlorpromazine had been synthesized but not yet marketed as an antipsychotic (Thorazine).
Erbo Dong+4 more
openaire +3 more sources
Diagnosis and Management of Beckwith-Wiedemann Syndrome
Beckwith-Wiedemann syndrome (BWS) is a human genomic imprinting disorder that presents with a wide spectrum of clinical features including overgrowth, abdominal wall defects, macroglossia, neonatal hypoglycemia, and predisposition to embryonal tumors. It
Kathleen H. Wang+5 more
doaj +1 more source
BackgroundITGA3 is a member of the integrin family, a cell surface adhesion molecule that can interact with extracellular matrix (ECM) proteins. The purpose of this study was to explore the significance of ITGA3 expression in the prognosis and clinical ...
Yue Li+10 more
doaj +1 more source
DNA methylation at the DAT promoter and risk for psychopathology. Intergenerational transmission between school-age youths and their parents in a community sample [PDF]
Background: The effect of gene polymorphisms and promoter methylation, associated with maladaptive developmental outcomes, vary depending on environmental factors (e.g., parental psychopathology).
Claudio D’Addario+9 more
core +2 more sources
Residential Proximity to Major Roadways at Birth, DNA Methylation at Birth and Midchildhood, and Childhood Cognitive Test Scores: Project Viva(Massachusetts, USA). [PDF]
BackgroundEpigenetic variability is hypothesized as a regulatory pathway through which prenatal exposures may influence child development and health.ObjectiveWe sought to examine the associations of residential proximity to roadways at birth and ...
Agha, Golareh+20 more
core +1 more source
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylation
N6-methyladenosine (m6A) is the most prevalent and reversible internal modification in mammalian messenger and non-coding RNAs. We report here that human METTL14 catalyzes m6A RNA methylation.
Jianzhao Liu+12 more
semanticscholar +1 more source
Fresh Insights Into SLC25A26: Potential New Therapeutic Target for Cancers: A Review
SLC25A26 is the only known human mitochondrial S-adenosylmethionine carrier encoding gene. Recent studies have shown that SLC25A26 is abnormally expressed in some cancers, such as cervical cancer, low-grade glioma, non-small cell lung cancer, and liver ...
Yangheng Xu+7 more
doaj +1 more source
Methylation Status of Imprinted Genes and Repetitive Elements in Sperm DNA from Infertile Males [PDF]
Stochastic, environmentally and/or genetically induced disturbances in the genome-wide epigenetic reprogramming processes during male germ-cell development may contribute to male infertility.
El Hajj, N.+7 more
core +1 more source
The Recognition of Protein Methylation Sites Based on CNN and Bi-LSTM Models
Methylation is a protein Post-Translational Modification (PTM) that regulates cell function ,which can provide guidance and help for research in the fields of gene regulation and disease prediction.
MA Chizhuo+3 more
doaj +1 more source