Results 51 to 60 of about 881,260 (340)

Methylation characteristics and clinical significance of glutathione peroxidase 3 in malignant pleomorphic adenoma

Kouqiang hemian waike zazhi
[Objective:] To observe the methylation and protein levels of glutathione peroxidase 3 (GPX3) in malignant pleomorphic adenoma (MPA) tissue and its clinical significance.
LIU Xiao, SUN Jiangwei, ZHOU Jing
doaj   +1 more source

Methyl-CpG-binding domain sequencing reveals a prognostic methylation signature in neuroblastoma [PDF]

, 2015
Accurate assessment of neuroblastoma outcome prediction remains challenging. Therefore, this study aims at establishing novel prognostic tumor DNA methylation biomarkers.
, Berbegall, Ana P., Bienertova-Vasku, Julie, Bown, Nick, Cannoodt, Robrecht, Clément, Nathalie, Combaret, Valérie, De Preter, Katleen, De Wilde, Bram, Decock, Anneleen, Haber, Michelle, Hoyoux, Claire, Laureys, Geneviève, Murray, Jayne, Noguera, Rosa, Ongenaert, Maté, Pierron, Gaelle, Schleiermacher, Gudrun, Schulte, Johannes H., Speleman, Frank, Stallings, Ray L., Tweddle, Deborah A., Van Roy, Nadine, Vandesompele, Jo, Verniers, Kimberly   +24 more
core   +2 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

m6 RNA methylation: an emerging common target in the immune response to cancer and severe acute respiratory syndrome-coronavirus-2 infection

Exploration of Medicine, 2023
m6A RNA methylation, a predominant type of RNA modification, is involved in regulating mRNA splicing, stability, and translation as well as the interaction between nucleoproteins and noncoding RNAs.
Hiromichi Sato, Tomoaki Hara, Chihiro Otsuka, Yasuko Arao, Yoshiko Tsuji, Yumiko Hamano, Mirei Ogita, Eric di Luccio, Takaaki Hirotsu, Andrea Vecchione, Hideshi Ishii   +10 more
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Prmt1-mediated histone H4R3me2a methylation regulates the proliferation, migration and invasion of laryngeal cancer cells by affecting the expression level of NCOA5

Frontiers in Oncology
BackgroundLaryngeal cancer is a common head and neck cancer, and its occurrence and development are closely related to a variety of epigenetic modifications.
Linlu Li, Jiao Cui, Xiaoyu Li, Yuting Zhu, Hongfei Wu, Lanzhu Zhou   +5 more
doaj   +1 more source

Complementarity between miRNA expression analysis and DNA methylation analysis in hrHPV-positive cervical scrapes for the detection of cervical disease

Epigenetics, 2019
Cervical screening by high-risk HPV (hrHPV) testing requires additional risk stratification (triage), as most infections are transient and only a subset of hrHPV-positive women harbours clinically relevant disease.
Iris Babion, Lise M.A. De Strooper, Roosmarijn Luttmer, Maaike C.G. Bleeker, Chris J.L.M. Meijer, Daniëlle A.M. Heideman, Saskia M. Wilting, Renske D.M. Steenbergen   +7 more
doaj   +1 more source

SETD3 is an actin histidine methyltransferase that prevents primary dystocia. [PDF]

, 2019
For more than 50 years, the methylation of mammalian actin at histidine 73 has been known to occur1. Despite the pervasiveness of His73 methylation, which we find is conserved in several model animals and plants, its function remains unclear and the ...
Carette, Jan E, Casey, Kerriann M, Cheng, Xiaodong, Cowan, Tina, Dai, Shaobo, Diep, Jonathan, Elias, Joshua E, Gozani, Or, Horton, John R, Li, Tie-Mei, Liu, Chao, Liu, Shuo, Mak, Justin, Nagamine, Claude M, Ooi, Yaw Shin, Ruppel, Katherine M, Song, Dan, Spudich, James A, Trivedi, Darshan V, Vilches-Moure, José G, Wilkinson, Alex W, Zhang, Xing   +21 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Exploring HLA-C methylation patterns and nutritional status in Kichwa mothers and infants from Tena, Ecuador

Frontiers in Medicine
Environment and lifestyle can affect the epigenome passed down from generation to generation. A mother’s nutrition can impact the methylation levels of her offspring’s epigenome, but it’s unclear which genes may be affected by malnutrition during ...
Erick Velastegui, Erick Velastegui, Isaac B. Falconí, Isaac B. Falconí, Valeria I. Garcia, Valeria I. Garcia, Gabriela Munizaga, Carmen Matias de la Cruz, Yaritza Segura, Kerly Alcivar, Luz Valencia, Edwin Vera, Mindy S. Muñoz, Wim Vanden Berghe, Sarah Lebeer, Andrea Orellana-Manzano   +15 more
doaj   +1 more source