Results 81 to 90 of about 1,050,423 (388)

Relationship between cognitive dysfunction and the promoter methylation of PER1 and CRY1 in patients with cerebral small vessel disease

Frontiers in Aging Neuroscience, 2023
Background and purposeThe prevalence of cerebral small vessel disease (CSVD) is increasing due to the accelerating global aging process, resulting in a substantial burden on all countries, as cognitive dysfunction associated with CSVD is also on the rise.
Yiwen Xu, Yugang Wang, Yi Jiang, Mengqian Liu, Wen Zhong, Zhonglin Ge, Zhichao Sun, Xiaozhu Shen   +7 more
doaj   +1 more source

Methylation status of Vitamin D receptor gene promoter in benign and malignant adrenal tumors [PDF]

, 2015
We previously showed a decreased expression of vitamin D receptor (VDR) mRNA/protein in a small group of adrenocortical carcinoma (ACC) tissues, suggesting the loss of a protective role of VDR against malignant cell growth in this cancer type ...
Cappellesso, Rocco, Fallo, Francesco, Fassina, Ambrogio, Guzzardo, Vincenza, Pilon, Catia, Rebellato, Andrea, Sasano, Hironobu, Urbanet, Riccardo   +7 more
core   +4 more sources

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Unidirectional alteration of methylation and hydroxymethylation at the promoters and differential gene expression in oral squamous cell carcinoma

Frontiers in Genetics, 2023
Background: Oral squamous cell carcinoma (OSCC) is one of the most common types of cancer worldwide. Although overall losses of 5-methylcytosine (5mC) and 5-hydroxymethylcytosine (5hmC) have been previously observed, a genome-wide, single-base-resolution,
Weizhi Zhao, Weizhi Zhao, Lin Zhu, Lin Zhu, Qian Gong, Qian Gong, Suzhen Ma, Suzhen Ma, Haofeng Xiong, Tong Su, Zhengqing Wan, Zhengqing Wan, Danling Wang, Danling Wang, Danling Wang   +14 more
doaj   +1 more source

Domain Model Explains Propagation Dynamics and Stability of Histone H3K27 and H3K36 Methylation Landscapes [PDF]

, 2020
Chromatin states must be maintained during cell proliferation to uphold cellular identity and genome integrity. Inheritance of histone modifications is central in this process. However, the histone modification landscape is challenged by incorporation of
Alabert, Allshire, Berry, Blackledge, Blasi, Coleman, Cooper, Ernst, Ferrari, Fröhlich, Hass, Healy, Hindmarsh, Hojfeldt, Huang, Højfeldt, Jani, Jasencakova, Jung, Justin, King, Langmead, Laprell, Laugesen, Lee, Loos, Loyola, Lu, MacLean, Maier, Margueron, Marks, McCabe, Mohammad, Noberini, Oksuz, Petryk, Poepsel, Reinberg, Reveron-Gomez, Sanulli, Scharf, Schmitges, Schuettengruber, Schwarz, Stafford, Stapor, Streubel, Tatton-Brown, van Mierlo, Voigt, Wasserman, Xu, Xu, Yu, Yu, Yuan, Zang, Zheng   +58 more
core   +3 more sources

The nicotinamide hypothesis revisited—plant defense signaling integrating PARP, nicotinamide, nicotinic acid, epigenetics, and glutathione

FEBS Letters, EarlyView.
Nicotinamide (NIC) and nicotinic acid (NIA) are proposed as stress signaling compounds in plants. Oxidative stress may lead to single strand breaks (SSB) in DNA, which activate poly(ADP‐ribose) polymerase (PARP). NIC and NIA are then formed from NAD. NIC and NIA can promote epigenetic changes leading to the expression of defense genes specific for the ...
Torkel Berglund, Anna B. Ohlsson
wiley   +1 more source

Epigenome‐wide association study of prostate cancer in African American men identified differentially methylated genes

Cancer Medicine
Introduction Men with African ancestry have the highest incidence and mortality rates of prostate cancer (PCa) worldwide. Methods This study aimed to identify differentially methylated genes between tumor vs. adjacent normal and aggressive vs.
Anders Berglund, Kosj Yamoah, Steven A. Eschrich, Rana Falahat, James J. Mulé, Sungjune Kim, Jaime Matta, Julie Dutil, Gilberto Ruiz‐Deya, Carmen Ortiz Sanchez, Liang Wang, Hyun Park, Hirendra N. Banerjee, Tamara Lotan, Kathryn Hughes Barry, Ryan M. Putney, Seung Joon Kim, Clement Gwede, Jacob K. Kresovich, Youngchul Kim, Hui‐Yi Lin, Jasreman Dhillon, Ratna Chakrabarti, Jong Y. Park   +23 more
doaj   +1 more source

Sulforaphane Suppressed Stemness Characters of Lung Adenocarcinoma Stem Cells by Down-regulating Methylation of miR-200c Promoter

Zhongliu Fangzhi Yanjiu, 2021
Objective To investigate the effect of sulforaphane (SFN) on the proliferation and self-renewal of lung cancer stem cells and its regulatory mechanism.
LIANG Guangxia, QIN Xituan, XIE Wei, XIE Youke   +3 more
doaj   +1 more source

VEZF1 elements mediate protection from DNA methylation [PDF]

, 2010
There is growing consensus that genome organization and long-range gene regulation involves partitioning of the genome into domains of distinct epigenetic chromatin states.
AC Bell, Adam G. West, AG West, AG West, AG West, Alan Hair, CD Lewis, CL Li, D Macleod, F Antequera, F Recillas-Targa, Gary Felsenfeld, H Gowher, Humaira Gowher, IG Lin, J Aitsebaomo, J Stalder, JA Wallace, Jacqueline Dickson, JH Chung, JH Chung, JP Issa, KS Wendt, L Valenzuela, Lisa Stubbs, M Brandeis, M Gaszner, M Marin, M Oki, MC Barton, Miklos Gaszner, MJ Pikaart, MM Suzuki, MN Prioleau, MN Prioleau, MS Turker, N Koyano-Nakagawa, PA Jones, PB Talbert, PD Jackson, PE Szabo, R Buckle, R Jaenisch, R Kellum, R Straussman, Ruslan Strogantsev, S Fan, S Huang, S Huang, S Yao, SP Clark, T Hashimshony, V Mutskov, VJ Mutskov, VK Rakyan   +54 more
core   +5 more sources

From lactation to malignancy: A comparison between healthy and cancerous breast gland at single‐cell resolution reveals new issues for tumorigenesis

FEBS Letters, EarlyView.
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona, Carlo M. Bergamini, Carlo Ferrari, Stefano Volinia, Nicoletta Bianchi   +4 more
wiley   +1 more source