Results 81 to 90 of about 641,368 (381)
Molecular Oncology, EarlyView.This study simultaneously investigated circulating tumor cells (CTCs) and exosomes from small‐cell lung cancer (SCLC) patients. The elevated expression of JUNB and CXCR4 in CTCs was a poor prognostic factor for SCLC patients, whereas exosomal overexpression of these biomarkers revealed a high discrimination ability of patients from healthy individuals,
Dimitrios Papakonstantinou +13 more
wiley +1 more source
The ALMA-PILS survey: first detection of methyl isocyanide (CH$_3$NC) in a solar-type protostar [PDF]
A&A 617, A95 (2018), 2018 Methyl isocyanide (CH$_3$NC) is the isocyanide with the largest number of atoms confirmed in the interstellar medium (ISM), but it is not an abundant molecule, having only been detected towards a handful of objects. Conversely, its isomer, methyl cyanide (CH$_3$CN), is one of the most abundant complex organic molecules detected in the ISM, with ...
arxiv +1 more source
Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer
Molecular Oncology, EarlyView.We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas +15 more
wiley +1 more source
Saudi Journal of Medicine and Medical Sciences, 2020 Background: Spleen tyrosine kinase (SYK) is an important enzyme in the proliferation and differentiation of all hematopoietic tissues. Its role as a cancer driver is well documented in liquid tumors; however, cumulative evidence has suggested an opposite
Akram I Alwithenani +1 more
doaj +1 more source
An interplay between BRD4 and G9a regulates skeletal myogenesis
Frontiers in Cell and Developmental Biology, 2022 Histone acetylation and methylation are epigenetic modifications that are dynamically regulated by chromatin modifiers to precisely regulate gene expression.
Naidi Yang +8 more
doaj +1 more source
Constraints of the formation and abundances of methyl carbamate, a glycine isomer, in hot corinos [PDF]
, 2020 Methyl carbamate CH$_3$OC(O)NH$_2$ is an isomer of glycine. Quantum chemical analyses show that methyl carbamate is more stable isomer than glycine. Because of this, there could be a higher chance for methyl carbamte to exist in the interstellar medium as compared to glycine.
arxiv +1 more source
Classification of acute myeloid leukemia based on multi‐omics and prognosis prediction value
Molecular Oncology, EarlyView.The Unsupervised AML Multi‐Omics Classification System (UAMOCS) integrates genomic, methylation, and transcriptomic data to categorize AML patients into three subtypes (UAMOCS1‐3). This classification reveals clinical relevance, highlighting immune and chromosomal characteristics, prognosis, and therapeutic vulnerabilities.
Yang Song +13 more
wiley +1 more source
Frontiers in Genetics, 2020 Objectives: The occurrence of hepatocellular carcinoma (HCC) is a complex process involving genetic mutations, epigenetic variation, and abnormal gene expression.
Ziyu Liu +6 more
doaj +1 more source
Frontiers in Oncology, 2022 DNA methylation is the most recognized epigenetic mark that leads to a massive distortion in cancer cells. It has been observed that a large number of DNA aberrant methylation events occur simultaneously in a group of genes, thus providing a growth ...
Federico Pio Fabrizio +15 more
doaj +1 more source
Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source