Results 81 to 90 of about 17,936 (269)

MHC Intratumoral Heterogeneity May Predict Cancer Progression and Response to Immunotherapy

Frontiers in Immunology, 2018
An individual tumor can present intratumoral phenotypic heterogeneity, containing tumor cells with different phenotypes that do not present irreversible genetic alterations.
Irene Romero, Cristina Garrido, Ignacio Algarra, Virginia Chamorro, Antonia Collado, Federico Garrido, Federico Garrido, Angel M. Garcia-Lora   +7 more
doaj   +1 more source

Snake venom toxins: Potential anticancer therapeutics

Journal of Applied Toxicology, Volume 44, Issue 5, Page 666-685, May 2024.
Abstract Snake venom contains a cocktail of compounds dominated by proteins and peptides, which make up the toxin. The toxin components of snake venom attack several targets in the human body including the neuromuscular system, kidney and blood coagulation system and cause pathologies. As such, the venom toxins can be managed and used for the treatment
Benedict C. Offor, Lizelle A. Piater
wiley   +1 more source

Photoelectrochemical Detection of Dengue-Related Oligonucleotide Sequence Using Anthocyanin as an Intercalating Agent and Electrochromic Material [PDF]

, 2010
World Health Organization (WHO) presupposes a confirmation of dengue virus infection diagnosis with two criteria, i.e. clinical and laboratory criteria.
Ibrahim, A. S. (Anwar), Kusmardi, K. (Kusmardi), Tedjo, A. (Aryo)   +2 more
core  

Nutritional Sources and Anticancer Potential of Phenethyl Isothiocyanate: Molecular Mechanisms and Therapeutic Insights

Molecular Nutrition &Food Research, Volume 68, Issue 8, April 2024.
Phenethyl Isothiocyanate (PEITC) exhibits its anticancer potential by modulating key signaling pathways, enforcing cell cycle arrest, promoting apoptosis, and enhancing drug efficacy by overcoming multidrug resistance and influencing drug metabolism enzymes.
Shahira M. Ezzat, Rana M. Merghany, Passent M. Abdel Baki, Nariman Ali Abdelrahim, Sohaila M. Osman, Mohamed A. Salem, Sheila I. Peña‐Corona, Hernán Cortés, Lashyn Kiyekbayeva, Gerardo Leyva‐Gómez, Javad Sharifi‐Rad, Daniela Calina   +11 more
wiley   +1 more source

Inhibition of liver methionine adenosyltransferase gene expression by 3-methylcolanthrene: protective effect of S-adenosylmethionine [PDF]

, 2001
Methionine adenosyltransferase (MAT) is an essential enzyme that catalyzes the synthesis of S-adenosylmethionine (AdoMet), the most important biological methyl donor. Liver MAT I/III is the product of the MAT1A gene.
Avila, M.A. (Matías Antonio), Carretero, M.V. (M. Victoria), Corrales, F.J. (Fernando José), Latasa, M.U. (María Ujué), Mato, J.M. (José María), Ruiz Garcia-Trevijano, E. (Elena), Wagner, C. (Conrad)   +6 more
core  

IL-23 suppresses innate immune response independently of IL-17A during carcinogenesis and metastasis [PDF]

, 2010
IL-23 is an important molecular driver of Th17 cells and has strong tumor-promoting proinflammatory activity postulated to occur via adaptive immunity.
A. Moller, Awasthi, B. von Scheidt, Cella, D. M. Andrews, G. R. Hill, Haak, Hu, Kaiga, Koebel, Kortylewski, Langowski, Lyakh, M. J. Smyth, M. Oft, M. W. L. Teng, Martin-Orozco, McKenzie, Moore, N. McLaughlin, O'Connor, Oppenheim, Overwijk, Parham, Presky, S. F. Ngiow, Shan, Smyth, Smyth, Street, Tesmer, Trinchieri, Wu, Y. Iwakura, Yen, Yuan, Zhou   +36 more
core   +1 more source

Pharmacokinetics of mirodenafil, a new erectogenic, and its metabolite, SK3541, in rats: involvement of CYP1A1/2, 2B1/2, 2D subfamily, and 3A1/2 for the metabolism of both mirodenafil and SK3541

Journal of Pharmacy & Pharmaceutical Sciences, 2010
Purpose. This study was performed to find which types of hepatic CYP isoforms are responsible for the metabolism of mirodenafil (a new erectogenic) and one of its metabolite, SK3541, using various hepatic CYP inducers and inhibitors in rats.
Young Hee Choi, Young Sun Lee, Myung Gull Lee, Tae Kon Kim, Bong-Yong Lee   +4 more
doaj   +1 more source

Modulation of CYP1A1 by PKC Inhibitors and TPA Pre-Treatments in MH1C1 Rat Hepatoma Cells Exposed to 3 -Methylcholanthrene [PDF]

, 2009
Cytochrome P4501A1 (CYP1A1), an enzyme known to metabolize polycyclic aromatic hydrocarbons, is regulated by the aryl hydrocarbon receptor (AhR). The involvement of protein kinase C (PKC) in the regulation of AhR signal transduction pathway, has been ...
Bassi, A., Bassi, A., Catalano, M., Catalano, M., De Pascale, C., De Pascale, C., Domenicotti, C., Domenicotti, C., Ledda, S., Ledda, S., Marengo, B., Marengo, B., Nitti, M., Nitti, M., Penco, S., Penco, S., Sanguineti, R., Sanguineti, R., Scanarotti, C., Scanarotti, C., Siri, M., Siri, M.   +21 more
core   +1 more source

Modulation of ethoxyresorufin-o-deethylase, benzoxyresorufin-o-dealkylase and pentoxyresorufin-o-dealkylase expression by African walnut seeds lipid extract in 3-methylcholanthrene induced breast cancer in Wistar rats [PDF]

, 2022
Esosa Samuel Uhunmwangho, Onoriode Oyiborhoro, Olafusi Celestina Oluwaseun   +2 more
openalex   +1 more source

Clonal evolution and progression of 20-methylcholanthrene-induced squamous cell carcinoma of mouse epidermis as revealed by DNA instability and other malignancy markers

European Journal of Histochemistry, 2009
We examined the clonal evolution of skin malignant lesions by repeated topical applications of 20- methylcholanthrene (20-MC) to the skin, which induces hyperplastic epidermis, papillomatous lesion and invasive carcinoma in mice.
K Hirai, M Kumakiri, K Ueda, Y Imamura, S Noriki, Y Nishi, H Kato, M Fukuda   +7 more
doaj   +1 more source