Results 11 to 20 of about 123 (115)
Angewandte Chemie, Volume 137, Issue 43, October 20, 2025.Herein we provide an overview of photochromic and photophysical properties of a broad variety of arylazo‐1,3,5‐trimethylpyrazole photoswitches, including the influence of 23 different para‐substituents. Measured half‐lives correlated in a Hammet plot are rationalized by density functional theory calculations, revealing the underlying thermal ...
Katharina Schlögl +6 more
wiley +2 more sources
A Fluorogenic Hydrazino‐Pictet–Spengler Reaction in Live Cells
Angewandte Chemie, Volume 137, Issue 40, September 26, 2025.A fluorogenic hydrazino‐Pictet–Spengler (HIPS) ligation reaction is used to label lipid‐derived aldehydes under wash‐free conditions in live cells. This innovative technique enables wash‐free imaging within biological systems, offering invaluable insights into the extent and localization of oxidative stress.
Kaleena Basran, Nathan W. Luedtke
wiley +2 more sources
Synthetic Strategies to Access Fluorinated Azoles
European Journal of Organic Chemistry, Volume 28, Issue 47, December 15, 2025.This review highlights recent synthetic strategies for introducing fluorine groups (mono‐, di‐, and trifluoromethylation) into 11 major azole classes, identifying research gaps to inform future innovations in materials science, medicinal chemistry, and biomedical research.
Mohammed K. Abd El‐Gaber +4 more
wiley +1 more source
Drug Discovery Applications of Nitroso (Hetero)Arene Derivatives
ChemPlusChem, Volume 90, Issue 12, December 10, 2025.Nitroso (hetero)aromatic compounds are bioactive molecules with antiviral, anticancer, neuroprotective, and antimicrobial properties. This review highlights their mechanisms of action—oxidative stress, DNA damage, and enzyme inhibition—alongside synthesis, structure–activity relationships, and toxicity challenges, offering insight into their ...
Silvia Roscales, Aurelio G. Csáky
wiley +1 more source
Sequential Optimization Approach Toward an Azapeptide‐Based SARS‐CoV‐2 Main Protease Inhibitor
Archiv der Pharmazie, Volume 358, Issue 12, December 2025.A series of small‐molecule azapeptides with various cysteine‐reactive electrophilic groups was designed, synthesized, and investigated for Mpro inhibition. Particularly suitable warheads were identified, and their linkage to a structurally expanded peptidomimetic scaffold afforded the potent lead compound 12, with kinac/Ki = 78,900 M–1s–1 and an ...
Rabea Voget +9 more
wiley +1 more source
Applied Organometallic Chemistry, Volume 39, Issue 11, November 2025.Monometallic and heterobimetallic Ru‐PdL complexes were synthesized and fully characterized. Their electrochemical properties were investigated by cyclic voltammetry. The Ru‐PdL complexes catalyzed the hydroarylation of NBD and the ROMP of Ph‐NBE. One complex catalyzed both reactions via tandem catalysis in one pot, converting NBD to poly (Ph‐NBE ...
Thais R. Cruz +6 more
wiley +1 more source
Asian Journal of Organic Chemistry, Volume 14, Issue 5, May 2025.The cascade Michael/intramolecular transamidation reactions of 3‐phenacylidene‐2‐indolinone derivatives bearing a trifluoromethyl group as a novel Michael acceptor with hydrazines yielded the corresponding pyrazolidin‐3‐one derivatives in good to high yields with excellent diastereoselectivity.
Ryo Tsuyusaki +4 more
wiley +1 more source
Archiv der Pharmazie, Volume 358, Issue 5, May 2025.The pyrazolo[4,3‐c][1,2]benzothiazine 5,5‐dioxide class was investigated with the aim of enlarging the array of Staphylococcus aureus NorA efflux pump inhibitors. The ethidium bromide efflux assay was used as a first indication of NorA inhibition; then, the ability of compounds to synergize with ciprofloxacin (CPX) against both wild‐type and resistant ...
Giada Cernicchi +14 more
wiley +1 more source
Small Science, Volume 5, Issue 5, May 2025.Utilizing the organic cation MHy with 2s2 lone‐pair electrons, the chiral‐polar lead‐free perovskite MHy3Bi2I9 is constructed in the famous A3Bi2I9 system. The symmetry breaking ascribes to the asymmetric transmission from MHy to the Bi2I9 inorganic skeleton through hydrogen bonding.
Ruiqing Li +8 more
wiley +1 more source
ChemCatChem, Volume 17, Issue 8, April 15, 2025.Transfer hydrogenation serves as an alternative platform to promote facile organic transformation in a selective and clean manner, due to its atomic economy, high efficiency, and sustainability. Hydrazine hydrate is one of the common reducing agents used in the selective transfer hydrogenation/reduction methodologies.
Michael G. Kallitsakis +2 more
wiley +1 more source