Results 21 to 30 of about 123 (115)
An up‐To‐Date Review of Elesclomol and Its Nano‐Formulations in Cancer Therapy
Cancer Reports, Volume 8, Issue 4, April 2025.ABSTRACT Background Elesclomol (ES) is a promising anticancer compound that exerts its effects through multiple mechanisms. It acts as a copper (Cu(II)) ionophore, forming an ES–Cu complex within cancer cells and inducing a novel form of cell death called cuproptosis.
Qi Wang +3 more
wiley +1 more source
Synthesis of Substituted Acyclic and Cyclic N‐Alkylhydrazines by Enzymatic Reductive Hydrazinations
ChemBioChem, Volume 26, Issue 4, February 16, 2025.Imine reductases (IREDs) offer promising synthesis routes for chiral amines. We have demonstrated reductive amination of diverse carbonyls and dicarbonyls with hydrazines, catalyzed by Myxococcus stipitatus IRED. Incorporating a hydrogenase cofactor regeneration system showcases the scalability and atom‐efficiency of H2‐driven double reductive ...
Niels Borlinghaus +3 more
wiley +1 more source
ChemistrySelect, Volume 10, Issue 2, January 15, 2025.This study represents a simple and straightforward synthetic approach to the formation of new cyclic 1,2,4‐triazolidine‐3‐thione compounds. The reaction of 2‐methylthiosemicarbazide with ketones leads to 2‐methylthiosemicarbazone cyclization, yielding 1,2,4‐triazolidine‐3‐thiones. Selected compounds were tested for cytotoxicity, antimicrobial activity,
Simona Gričar +5 more
wiley +1 more source
Two‐Step Synthesis of Enantiomerically Pure Morphans from (R)‐Carvone
ChemMedChem, Volume 19, Issue 24, December 16, 2024.A two‐step procedure transformed the natural product (R)‐carvone into enantiomerically pure morphans allowing selective modifications at 2‐, 4‐ and 6/7‐position. Whereas affinity towards opioid receptors could not be detected, nanomolar σ1 affinity was found for indolomorphans and quinolinomorphans.
Giuliana Costanzo +5 more
wiley +1 more source
Archiv der Pharmazie, Volume 357, Issue 10, October 2024.Novel phthalazine‐1,4‐dione acetylcholinesterase (AChE) inhibitors with exceptional activity against Alzheimer's disease were synthesized and evaluated. Three compounds, 8m, 8n, and 8p, demonstrated remarkable AChE inhibition similar to donepezil. Molecular docking and dynamic simulations confirmed stability and therapeutic potential as a significant ...
Demokrat Nuha +4 more
wiley +1 more source
The Hydrazine Moiety in the Synthesis of Modified Nucleosides and Nucleotides
ChemMedChem, Volume 19, Issue 16, August 19, 2024.Nucleoside derivatives synthesized from hydrazine‐ribose units have been in development for a long time, but surprisingly no inventory has been carried out to date about their synthesis and biological properties. With the aim of filling this gap, this review provides an examination of the chemical synthesis, and potential biological activity of these ...
Anaïs Guillou +4 more
wiley +1 more source
Tailoring of the polarization‐resolved second harmonic generation in two‐dimensional semiconductors
Nanophotonics, Volume 13, Issue 18, Page 3181-3206, August 2024.Abstract Second harmonic generation is a non‐linear optical phenomenon in which coherent radiation with frequency ω interacts with a non‐centrosymmetric material and produces coherent radiation at frequency 2ω. Owing to the exciting physical phenomena that take place during the non‐linear optical excitation at the nanoscale, there is currently ...
Sotiris Psilodimitrakopoulos +4 more
wiley +1 more source
Protein NMR Spectroscopy at 150 kHz Magic-Angle Spinning Continues To Improve Resolution and Mass Sensitivity. [PDF]
Chembiochem, 2020 Schledorn M +12 more
europepmc +1 more source
The Discovery of Highly Potent THP Derivatives as OCTN2 Inhibitors: From Structure-Based Virtual Screening to In Vivo Biological Activity. [PDF]
Int J Mol Sci, 2020 Di Cristo F +8 more
europepmc +1 more source
Insights into Lipid-Based Delivery Nanosystems of Protein-Tyrosine Kinase Inhibitors for Cancer Therapy. [PDF]
Pharmaceutics, 2022 Jampilek J, Kralova K.
europepmc +1 more source