Results 51 to 60 of about 334 (89)

Glutathione-PEGylated liposomal methylprednisolone in comparison to free methylprednisolone: slow release characteristics and prolonged lymphocyte depression in a first-in-human study. [PDF]

Br J Clin Pharmacol, 2018
Kanhai KMS, Zuiker RGJA, Stavrakaki I, Gladdines W, Gaillard PJ, Klaassen ES, Groeneveld GJ.   +6 more
europepmc   +1 more source

Are We Considering All the Potential Drug-Drug Interactions in Women's Reproductive Health? A Predictive Model Approach. [PDF]

Pharmaceutics
Garcia-Acero P, Henarejos-Castillo I, Sanz FJ, Sebastian-Leon P, Parraga-Leo A, Garcia-Velasco JA, Diaz-Gimeno P.   +6 more
europepmc   +1 more source

Targeted nanoliposomes for precision rheumatoid arthritis therapy: a review on mechanisms and in vivo potential. [PDF]

Drug Deliv
Girase R, Gujarathi NA, Sukhia A, Kota SSN, Patil TS, Aher AA, Agrawal YO, Ojha S, Sharma C, Goyal SN.   +9 more
europepmc   +1 more source

Corticosteroids for treating sepsis in children and adults. [PDF]

Cochrane Database Syst Rev
Annane D, Briegel J, Granton D, Bellissant E, Bollaert PE, Keh D, Kupfer Y, Pirracchio R, Rochwerg B.   +8 more
europepmc   +1 more source

Revolutionizing rheumatoid arthritis therapy: the potential of lipid nanocarriers. [PDF]

RSC Adv
Alarcon JF, Karusan NR, Presciutti C, Miras J, Magana JR, Guerra-Rebollo M, Borrós S, Ahmad N, Fornaguera C.   +8 more
europepmc   +1 more source

Histoplasmosis in Immunocompromised and Immunocompetent Patients in Guadeloupe. [PDF]

J Fungi (Basel)
Lahuna C, Dequidt T, Postel-Vinay P, Peugny S, Haboub M, Markowicz S, Nicolas M.   +6 more
europepmc   +1 more source

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Hydrolysis of methylprednisolone hemisuccinate to methylprednisolone by a nonspecific carboxylesterase

Pharmacological Research Communications, 1980
Summary Enzymatic hydrolysis of methylprednisolone hemisuccinate with a non-specific carboxylesterase from hog liver was examined. The carboxyl-exterase was found to be useful in hydrolyzing methylprednisolone hemisuccinate to methylprednisolone.
T, Oshima, E, Nakajima, K, Hattori
exaly   +3 more sources

Kinetics of methylprednisolone and its hemisuccinate ester

Clinical Pharmacology and Therapeutics, 1985
Methylprednisolone in the form of its hemisuccinate ester was injected intravenously in doses of 10 mg/kg and 63.1 mg. Plasma levels of methylprednisolone and of the ester were measured and their kinetics were calculated. Results indicate dose dependency in the kinetics of both. About 10% of the dose was excreted unchanged as hemisuccinate in the urine,
Hartmut Derendorf, P Rohdewald, H Möllmann   +2 more
exaly   +3 more sources

Initial Rate Studies of Hydrolysis and Acyl Migration in Methylprednisolone 21-Hemisuccinate and 17-Hemisuccinate

Journal of Pharmaceutical Sciences, 1981
The degradation of methylprednisolone 21-succinate in aqueous solution was examined as a function of pH at 25 degrees by monitoring the initial rates of product formation. In addition to hydrolysis, acyl migration fro the 21-hydroxyl group was found to be an important reaction.
B D Anderson
exaly   +3 more sources