Results 31 to 40 of about 292,501 (293)

Identification and gene expression analysis of cytosine-5 DNA methyltransferase and demethylase genes in Amaranthus cruentus L. under heavy metal stress

Frontiers in Plant Science, 2023
Amaranth has become increasingly popular due to its highly nutritious grains and ability to tolerate environmental stress. The mechanism underlying defense and adaptation to environmental stress is a complicated process involving DNA methylation and ...
Veronika Lancíková, Jana Kačírová, Andrea Hricová   +2 more
doaj   +1 more source

Abnormality of m6A mRNA Methylation Is Involved in Alzheimer’s Disease

Frontiers in Neuroscience, 2020
Alzheimer’s disease (AD), the most common form of dementia, is highly prevalent in older adults. The main clinical feature is the progressive decline of memory function, which eventually leads to the decline of cognitive function.
Min Han, Zhen Liu, Yingying Xu, Xiangtian Liu, Dewei Wang, Fan Li, Yun Wang, Jianzhong Bi   +7 more
doaj   +1 more source

Downregulation of METTL7B Inhibits Proliferation of Human Clear Cell Renal Cancer Cells In Vivo and In Vitro

Frontiers in Oncology, 2021
Clear cell renal cell carcinoma (ccRCC) is the most aggressive urologic tumor, and its incidence and diagonosis have been continuously increasing. Identifying novel molecular biomarker for inhibiting the progression of ccRCC will facilitate developing ...
Wei Li, Shi Xu, Naixiong Peng, Zejian Zhang, Hua He, Ruoyu Chen, Dong Chen, Jiqing Fan, Xisheng Wang   +8 more
doaj   +1 more source

SUMO1 modification of methyltransferase-like 3 promotes tumor progression via regulating Snail mRNA homeostasis in hepatocellular carcinoma

Theranostics, 2020
Rationale: Hepatocellular carcinoma (HCC) is one of the leading causes of mortality worldwide. Methyltransferase-like 3 (Mettl3), an RNA N6-methyladenosine (m6A) methyltransferase, has been shown to act as an oncogene in several human cancers.
Hongfa Xu, Hao Wang, Wei Zhao, Sirui Fu, Yong Li, W. Ni, YongJie Xin, Wei Li, Chenzi Yang, Yanyan Bai, Meixiao Zhan, Ligong Lu   +11 more
semanticscholar   +1 more source

Clinical and Biological Significances of a Methyltransferase-Related Signature in Diffuse Glioma

Frontiers in Oncology, 2020
Methylation of DNA, RNA or protein is a reversible modification. The proteins and genes that regulate this modification can be a candidate target for tumor therapy. However, the characteristics of methyltransferase related genes in glioma remain obscure.
Ying Zhang, Ying Zhang, Yuqing Liu, Yuqing Liu, Hanjie Liu, Hanjie Liu, Zheng Zhao, Zheng Zhao, Fan Wu, Fan Wu, Fan Zeng, Fan Zeng   +11 more
doaj   +1 more source

N6 -Methyladenosine Modification in Chronic Stress Response Due to Social Hierarchy Positioning of Mice

Frontiers in Cell and Developmental Biology, 2021
Appropriately responding to stressful events is essential for maintaining health and well-being of any organism. Concerning social stress, the response is not always as straightforward as reacting to physical stressors, e.g., extreme heat, and thus has ...
Malena dos Santos Guilherme, Theodora Tsoutsouli, Hristo Todorov, Sina Teifel, Vu Thu Thuy Nguyen, Susanne Gerber, Kristina Endres   +6 more
doaj   +1 more source

The rRNA m6A methyltransferase METTL5 is involved in pluripotency and developmental programs

Genes & Development, 2020
In this study, Ignatova et al. performed a systematic screen to uncover new RNA methyltransferases, and demonstrate that the methyltransferase-like 5 (METTL5) protein catalyzes m6A in 18S rRNA at position A1832.
V. Ignatova, P. Stolz, Steffen Kaiser, Tobias H Gustafsson, Palma Rico Lastres, A. Sanz-Moreno, Yi-Li Cho, O. Amarie, Antonio Aguilar-Pimentel, Tanja Klein-Rodewald, J. Calzada-Wack, L. Becker, S. Marschall, M. Kraiger, L. Garrett, C. Seisenberger, S. Hölter, Kayla M Borland, E. van de Logt, P. Jansen, Marijke P. A. Baltissen, Magdalena Valenta, M. Vermeulen, W. Wurst, V. Gailus-Durner, H. Fuchs, M. Hrabě de Angelis, O. Rando, Stefanie M. Kellner, Sebastian Bultmann, R. Schneider   +30 more
semanticscholar   +1 more source

Identification and Characterization of Zika Virus NS5 Methyltransferase Inhibitors

Frontiers in Cellular and Infection Microbiology, 2021
The recurring outbreak of Zika virus (ZIKV) worldwide makes an emergent demand for novel, safe and efficacious anti-ZIKV agents. ZIKV non-structural protein 5 (NS5) methyltransferase (MTase), which is essential for viral replication, is regarded as a ...
Weibao Song, Hongjuan Zhang, Yu Zhang, Ying Chen, Yuan Lin, Yanxing Han, Jiandong Jiang   +6 more
doaj   +1 more source

Altered Expression of the m6A Methyltransferase METTL3 in Alzheimer’s Disease

eNeuro, 2020
Cognitive impairment in Alzheimer’s disease (AD) is associated with dysregulation of the RNA and protein expression profiles in the brain. Recent studies have highlighted the importance of RNA post-transcriptional regulation (epitranscriptomics) in ...
He Huang 黄 河, Judith Camats-Perna, R. Medeiros, Victor Anggono, Jocelyn Widagdo   +4 more
semanticscholar   +1 more source

An emerging maestro of immune regulation: how DOT1L orchestrates the harmonies of the immune system

Frontiers in Immunology
The immune system comprises a complex yet tightly regulated network of cells and molecules that play a critical role in protecting the body from infection and disease.
Liam Kealy, Jessica Runting, Daniel Thiele, Sebastian Scheer, Sebastian Scheer   +4 more
doaj   +1 more source