Results 31 to 40 of about 154,259 (119)
Targets of histone H3 lysine 9 methyltransferases
Frontiers in Cell and Developmental Biology, 2022 Histone H3 lysine 9 di- and trimethylation are well-established marks of constitutively silenced heterochromatin domains found at repetitive DNA elements including pericentromeres, telomeres, and transposons. Loss of heterochromatin at these sites causes
Aidan J. Levinsky +7 more
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Strategic Intelligence on Emerging Technologies: Scientometric Overlay Mapping [PDF]
, 2013 This paper examines the use of scientometric overlay mapping as a tool of 'strategic intelligence' to aid the governance of emerging technologies. We develop an integrative synthesis of different overlay mapping techniques and associated perspectives on technological emergence across the geographical, social, and cognitive spaces.
arxiv +1 more source
SUV39 SET domains mediate crosstalk of heterochromatic histone marks
eLife, 2021 The SUV39 class of methyltransferase enzymes deposits histone H3 lysine 9 di- and trimethylation (H3K9me2/3), the hallmark of constitutive heterochromatin.
Alessandro Stirpe +7 more
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Viruses, 2023 The human respiratory syncytial virus (RSV) is a negative-sense, single-stranded RNA virus. It is the major cause of severe acute lower respiratory tract infection in infants, the elderly population, and immunocompromised individuals.
Priscila Sutto-Ortiz +3 more
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Biology, 2023 Impaired adipocyte function contributes to systemic metabolic dysregulation, and altered fat mass or function increases the risk of Type 2 diabetes. EHMTs 1 and 2 (euchromatic histone lysine methyltransferases 1 and 2), also known as the G9a-like protein
Ashley A. Able +2 more
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Comparison of Machine Learning Classifiers to Predict Patient Survival and Genetics of GBM: Towards a Standardized Model for Clinical Implementation [PDF]
arXiv, 2021 Radiomic models have been shown to outperform clinical data for outcome prediction in glioblastoma (GBM). However, clinical implementation is limited by lack of parameters standardization. We aimed to compare nine machine learning classifiers, with different optimization parameters, to predict overall survival (OS), isocitrate dehydrogenase (IDH ...
arxiv
16S rRNA Methyltransferase RmtC in Salmonella enterica Serovar Virchow
Emerging Infectious Diseases, 2010 We screened Salmonella and Escherichia coli isolates, collected 2004–2008 in the United Kingdom, for 16S rRNA methyltransferases. rmtC was identified in S. enterica serovar Virchow isolates from clinical samples and food.
Katie L. Hopkins +3 more
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Molecules, 2023 In this work, the catalytic mechanism of loganic acid methyltransferase was characterized at the molecular level. This enzyme is responsible for the biosynthesis of loganin, which is a precursor for a wide range of biologically active compounds.
Mateusz Jędrzejewski +2 more
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Artificial Intelligence Solution for Effective Treatment Planning for Glioblastoma Patients [PDF]
arXiv, 2022 Glioblastomas are the most common malignant brain tumors in adults. Approximately 200000 people die each year from Glioblastoma in the world. Glioblastoma patients have a median survival of 12 months with optimal therapy and about 4 months without treatment.
arxiv
Frontiers in Genetics, 2020 RNA methylation accounts for over 60% of all RNA modifications, and N6-methyladenosine (m6A) is the most common modification on mRNA and lncRNA of human beings. It has been found that m6A modification occurs in microRNA, circRNA, rRNA, and tRNA, etc. The
Jiaju Xu +17 more
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