Results 41 to 50 of about 154,259 (119)
Lysine Methyltransferase SMYD1 Regulates Myogenesis via skNAC Methylation
Cells, 2023 The SMYD family is a unique class of lysine methyltransferases (KMTases) whose catalytic SET domain is split by a MYND domain. Among these, Smyd1 was identified as a heart- and skeletal muscle-specific KMTase and is essential for cardiogenesis and ...
Li Zhu +6 more
doaj +1 more source
BTDNet: a Multi-Modal Approach for Brain Tumor Radiogenomic Classification [PDF]
arXiv, 2023 Brain tumors pose significant health challenges worldwide, with glioblastoma being one of the most aggressive forms. Accurate determination of the O6-methylguanine-DNA methyltransferase (MGMT) promoter methylation status is crucial for personalized treatment strategies. However, traditional methods are labor-intensive and time-consuming.
arxiv
Targeting epigenetic processes in photodynamic therapy-induced anticancer immunity
Frontiers in Oncology, 2015 Photodynamic therapy (PDT) of cancer is an approved therapeutic procedure that generates oxidative stress leading to cell death of tumour and stromal cells.
Malgorzata eWachowska +2 more
doaj +1 more source
Adaptive Fine-tuning based Transfer Learning for the Identification of MGMT Promoter Methylation Status [PDF]
arXiv, 2023 Glioblastoma Multiforme (GBM) is an aggressive form of malignant brain tumor with a generally poor prognosis. Treatment usually includes a mix of surgical resection, radiation therapy, and akylating chemotherapy but, even with these intensive treatments, the 2-year survival rate is still very low.
arxiv
Frontiers in Microbiology, 2018 The cell surface of the oral pathogen Tannerella forsythia is heavily glycosylated with a unique, complex decasaccharide that is O-glycosidically linked to the bacterium’s abundant surface (S-) layer, as well as other proteins.
Markus B. Tomek +14 more
doaj +1 more source
How large should the QM region be in QM/MM calculations? The case of catechol O-methyltransferase [PDF]
, 2015 Hybrid quantum mechanical-molecular mechanical (QM/MM) simulations are widely used in studies of enzymatic catalysis. Until recently, it has been cost prohibitive to determine the asymptotic limit of key energetic and structural properties with respect to increasingly large QM regions.
arxiv +1 more source
mSphere, 2016 Penicillium chrysogenum is the sole industrial producer of the β-lactam antibiotic penicillin, which is the most commonly used drug for treating bacterial infections. In P.
Kordula Becker +4 more
doaj +1 more source
Frontiers in Plant Science, 2023 A genome-wide association study (GWAS), which uses information on single nucleotide polymorphisms (SNPs) from many accessions, has become a powerful approach to gene identification.
Kai Uchida +10 more
doaj +1 more source
Open-radiomics: A Collection of Standardized Datasets and a Technical Protocol for Reproducible Radiomics Machine Learning Pipelines [PDF]
arXiv, 2022 Background: As an important branch of machine learning pipelines in medical imaging, radiomics faces two major challenges namely reproducibility and accessibility. In this work, we introduce open-radiomics, a set of radiomics datasets along with a comprehensive radiomics pipeline based on our proposed technical protocol to improve the reproducibility ...
arxiv
Subtelomeric Chromatin in the Fission Yeast S. pombe
Microorganisms, 2021 Telomeres play important roles in safeguarding the genome. The specialized repressive chromatin that assembles at telomeres and subtelomeric domains is key to this protective role.
Rajesh K. Yadav +4 more
doaj +1 more source