Results 41 to 50 of about 292,501 (293)

The N-Terminal α-Helix of Potato Virus X-Encoded RNA-Dependent RNA Polymerase Is Required for Membrane Association and Multimerization

Viruses, 2022
Positive-sense single-stranded RNA viruses replicate in virus-induced membranous organelles for maximum efficiency and immune escaping. The replication of potato virus X (PVX) takes place on the endoplasmic reticulum (ER); however, how PVX-encoded RNA ...
Xue Jiang, Yameng Luan, Mengzhu Chai, Yingshuai Yang, Yuting Wang, Wenjia Deng, Yonggang Li, Xiaofei Cheng, Xiaoyun Wu   +8 more
doaj   +1 more source

Methyltransferase like 3 promotes colorectal cancer proliferation by stabilizing CCNE1 mRNA in an m6A‐dependent manner

Journal of Cellular and Molecular Medicine, 2020
m6A modification is the most prevalent RNA modification in eukaryotes. As the critical N6‐methyladenosine (m6A) methyltransferase, the roles of methyltransferase like 3 (METTL3) in colorectal cancer (CRC) are controversial. Here, we confirmed that METTL3,
Wei Zhu, Y. Si, Jun Xu, Yu Lin, Jing-zi Wang, Mengda Cao, Shanwen Sun, Q. Ding, Lingjun Zhu, Ji-Fu Wei   +9 more
semanticscholar   +1 more source

Genomewide Analysis of Mode of Action of the S-Adenosylmethionine Analogue Sinefungin in Leishmania infantum

mSystems, 2019
To further our understanding of one-carbon metabolism in the protozoan parasite Leishmania, we conducted genomic screens to study how the parasite responded to sinefungin (SNF) selection.
Arijit Bhattacharya, Mansi Sharma, Charles Packianathan, Barry P. Rosen, Philippe Leprohon, Marc Ouellette   +5 more
doaj   +1 more source

The Promise for Histone Methyltransferase Inhibitors for Epigenetic Therapy in Clinical Oncology: A Narrative Review

Advances in Therapy, 2020
Epigenetic processes are essential for normal development and the maintenance of tissue-specific gene expression in mammals. Changes in gene expression and malignant cellular transformation can result from disruption of epigenetic mechanisms, and global ...
H. Rugo, I. Jacobs, Shikhar Sharma, F. Scappaticci, T. Paul, K. Jensen-Pergakes, G. Malouf   +6 more
semanticscholar   +1 more source

Angucyclinones rescue PhLOPSA antibiotic activity by inhibiting Cfr-dependent antibiotic resistance

mBio, 2023
Methylation of the ribosome is a prevalent strategy conferring resistance to antibiotics that inhibit protein synthesis. Methylation is catalyzed by several distinct enzymes, many encoded on mobile genetic elements widespread in bacteria. One enzyme that
Adam J. Schaenzer, Annia Rodriguez Hernandez, Kaitlyn Tsai, Christian Hobson, Danica Galonić Fujimori, Gerard D. Wright   +5 more
doaj   +1 more source

Global Survey and Genome Exploration of Bacteriophages Infecting the Lactic Acid Bacterium Streptococcus thermophilus

Frontiers in Microbiology, 2017
Despite the persistent and costly problem caused by (bacterio)phage predation of Streptococcus thermophilus in dairy plants, DNA sequence information relating to these phages remains limited.
Brian McDonnell, Jennifer Mahony, Jennifer Mahony, Laurens Hanemaaijer, Horst Neve, Jean-Paul Noben, Gabriele A. Lugli, Marco Ventura, Thijs R. Kouwen, Douwe van Sinderen, Douwe van Sinderen   +10 more
doaj   +1 more source

Trichoderma harzianum Volatile Organic Compounds Regulated by the THCTF1 Transcription Factor Are Involved in Antifungal Activity and Beneficial Plant Responses

Journal of Fungi, 2023
The transcription factor THCTF1 from Trichoderma harzianum, previously linked to the production of 6-pentyl-2H-pyran-2-one (6-PP) derivatives and antifungal activity against Fusarium oxysporum, has been related in this study to conidiation, production of
María Belén Rubio, Maurilia Maria Monti, Liberata Gualtieri, Michelina Ruocco, Rosa Hermosa, Enrique Monte   +5 more
doaj   +1 more source

SUMOylation of the m6A-RNA methyltransferase METTL3 modulates its function

Nucleic Acids Research, 2018
The methyltransferase like 3 (METTL3) is a key component of the large N6-adenosine-methyltransferase complex in mammalian responsible for N6-methyladenosine (m6A) modification in diverse RNAs including mRNA, tRNA, rRNA, small nuclear RNA, microRNA ...
Yuzhang Du, Guofang Hou, Hailong Zhang, Jinzhuo Dou, Jianfeng He, Yanming Guo, Lian Li, Ran Chen, Yanli Wang, R. Deng, Jian Huang, B. Jiang, Ming Xu, Jinke Cheng, Guoqiang Chen, Xian Zhao, Jianxiu Yu   +16 more
semanticscholar   +1 more source

Evidence of Adaptive Evolution in Wolbachia-Regulated Gene DNMT2 and Its Role in the Dipteran Immune Response and Pathogen Blocking

Viruses, 2021
Eukaryotic nucleic acid methyltransferase (MTase) proteins are essential mediators of epigenetic and epitranscriptomic regulation. DNMT2 belongs to a large, conserved family of DNA MTases found in many organisms, including holometabolous insects such as ...
Tamanash Bhattacharya, Danny W. Rice, John M. Crawford, Richard W. Hardy, Irene L. G. Newton   +4 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source