Results 171 to 180 of about 124,916 (340)

Dual Aptamers‐Based SETDB1 PROTACs as Effective Anti‐Tumor Strategies for Breast Cancer

Advanced Science, EarlyView.
This study establishes dual‐aptamer PROTACs targeting SETDB1 using a SETDB1‐specific aptamer conjugated to AS1411. The designed PROTACs penetrate cells, recruit MDM2 to degrade SETDB1, and inhibit cancer cell proliferation and migration. Remarkably, they also overcome tamoxifen resistance and enhance CD8+ T cell cytotoxicity, suppressing tumor growth ...
Yanxuan Guo, Yingge Lv, Shuyu Huang, Chang Liu, Yan Ouyang, Bei Lan, Chenghao Xuan   +6 more
wiley   +1 more source

Defining substrate specificities of human RNA capping methyltransferases through quantitative assessment of independent yet cooperative activities. [PDF]

Protein Sci
Taherian F, Mabanglo MF, Hajian T, Tucker S, Kalinic E, Perveen S, Aman A, Vedadi M.   +7 more
europepmc   +1 more source

Arsenic Methyltransferase and Methylation of Inorganic Arsenic [PDF]

, 2020
Nirmal Roy, Anthony Murphy, Max Costa
openalex   +1 more source

A Statistical Mechanics Model to Decode Tissue Crosstalk During Graft Formation

Advanced Science, EarlyView.
We introduce a statistical mechanics framework to decode the genomic crosstalk governing plant grafting. By integrating evolutionary game theory with transcriptomics, we reconstruct idopNetworks (informative, dynamic, omnidirectional, and personalized networks) that map scion–rootstock interactions.
Ang Dong, Yihan Meng, Stephen Shing‐Toung Yau, Shing‐Tung Yau, Rongling Wu   +4 more
wiley   +1 more source

The effects of genetically determined plasma methyltransferases on digestive system cancers: a comprehensive bidirectional two-sample Mendelian randomization analysis. [PDF]

Discov Oncol
Zhang C, Li X, Dong Z, Weng Y, Yu W, Cai X.   +5 more
europepmc   +1 more source

Multiple Isoforms of DNA Methyltransferase Are Encoded by the Vertebrate Cytosine DNA Methyltransferase Gene

, 1998
Jing Deng, Moshe Szyf
openalex   +1 more source

The histone H3 lysine 9 methyltransferase G9a/GLP complex activity is required for long-term consolidation of spatial memory in mice

, 2021
Kyrian Nicolay-Kritter, Jordan Lassalle, Jean‐Louis Guillou, Nicole Mons   +3 more
openalex   +2 more sources

New Insights Into Changes in the DNA Methylation Pattern of the SHOX Gene in Patients With Léri‐Weill Dyschondrosteosis

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT SHOX gene haploinsufficiency is associated with Léri‐Weill dyschondrosteosis (LWD) or idiopathic short stature (ISS) and could be caused by the structural and point mutations in the coding region and by the deletions in SHOX gene regulatory sequences. The role of the duplications in regulatory sequences is ambivalent.
Valeriia Kopytko, Katerina Hirschfeldova, Pavlina Capkova, Roman Solc   +3 more
wiley   +1 more source

Methanogenic activities signatures in broilers fed black soldier fly (<i>Hermetia illucens</i>) larvae-based diets. [PDF]

Biochem Biophys Rep
Ibiwoye DO, Oladejo OA, Akinsola OA, Adekiya AO, Alabi OM, Ayansina AD, Dahunsi SO.   +6 more
europepmc   +1 more source

An epigenetic approach for the determinism of the "mantled" somaclonal variation in oil palm [PDF]

, 2008
Rival, Alain
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