Results 181 to 190 of about 64,774 (259)

Ketogenic diet for infantile epileptic spasms

Epilepsia Open, EarlyView.
Abstract Approximately half of all cases of Infantile Epileptic Spasms Syndrome (IESS) do not respond to vigabatrin and hormonal therapies. There is no clear consensus as to the second‐line therapy for IESS. Ketogenic diet (KD) has emerged as an effective treatment for certain drug‐resistant epilepsies and in many cases of IESS.
Morris H. Scantlebury, Anamika Choudhary, Andy Cheuk‐Him Ng, Cezar Gavrilovici   +3 more
wiley   +1 more source

Vaginal host–microbe signatures linked to placental outcomes in mares

Equine Veterinary Journal, EarlyView.
Abstract Background Ascending placentitis is a leading cause of late‐term pregnancy loss in mares. Although pathogens are presumed to ascend from the caudal reproductive tract, the association between the vaginal microbiome and placentitis has not been systematically examined.
Machteld van Heule, Babiche Heil, Jamie K. Norris, Kristene Gedye, Xiaoxiao Lin, Ward De Spiegelaere, Peter Daels, Pouya Dini   +7 more
wiley   +1 more source

Dual inhibition of PRMT1 and SUV39H1 suppresses breast cancer progression and enhances immunotherapy response. [PDF]

Int J Biol Sci
Wang G, Song J, Duan X, Zhou K, Zhang J, Zhang H, Yu Y.   +6 more
europepmc   +1 more source

Phytochemical profiling and bioactivity evaluation of Anthocephalus cadamba flower extracts through in vitro, and in silico studies

Food Biomacromolecules, EarlyView.
Abstract Anthocephalus cadamba (Kadamba) is a medicinally important tropical plant with well‐documented antioxidant, anti‐inflammatory, and antimicrobial properties. However, comparative evaluation of solvent extraction efficiency combined with computational validation of bioactive compounds remains limited.
Manisha Panchal, Diksha Sharma, Sunita Khatak, Raushan Kumar Jha, Surbhi Panwar, Ashwani Kumar   +5 more
wiley   +1 more source

Expression profiles of histone H4K20 methylation and its associated enzymes in mouse cardiac disease and human heart failure. [PDF]

Epigenetics
Hickenlooper S, Brady C, Bia R, Visker JR, Wang L, Valdez S, Gwynn C, Roland MN, Kyriakopoulos CP, Sideris K, Drakos SG, Szulik MW, Franklin S.   +12 more
europepmc   +1 more source

Broad Epigenetic Shifts in the Aging Drosophila Retina Contribute to Its Altered Diurnal Rhythmic Transcriptome. [PDF]

Aging Cell
McGovern SE, Meng G, Marlin MN, Pruitt SA, Weake VM.   +4 more
europepmc   +1 more source

Improving genetic diagnosis of hereditary tumor syndromes: From expanded gene panels to functional genomics

International Journal of Cancer, EarlyView.
Abstract Genetic tumor risk syndromes (genturis) contribute substantially to the overall cancer burden and provide opportunities for early detection, prevention, and individualized treatment. Yet, many affected individuals remain undiagnosed due to restrictive testing criteria and challenges in variant interpretation.
Mayra Sauer, Morghan C. Lucas, Vitus Prokosch, Thomas Keßler, Thomas Risch, Andreas Laner, Jan Henkel, Anna Benet‐Pagès, Ariane Hallermayr, Verena Steinke‐Lange, Elke Holinski‐Feder, Barbara Klink   +11 more
wiley   +1 more source

Epigenetic regulation in prokaryotes: transcriptional and phenotypic outcomes of DNA methyltransferase activity. [PDF]

FEMS Microbiol Rev
Sharaf S, Cappelletti M, Oggioni MR, Hijazi K.   +3 more
europepmc   +1 more source

Epigenetic Dysregulation of Somatostatin Receptors (SSTR) 1–5 and Therapeutic Implications in Neuroendocrine and Non‐Neuroendocrine Malignancies

International Journal of Cancer, EarlyView.
ABSTRACT Somatostatin receptors (SSTR) mediate the antiproliferative, antisecretory, and proapoptotic effects of somatostatin and its synthetic analogs. Their surface expression on neuroendocrine tumor (NET) cells is required for somatostatin analog therapy and radiopharmaceutical therapy (RPT).
Neeraj Kumari, Pablo Hoffmann, Laura Reichl, Maximilian Schmutz, Nina Fischer, Thi Tuong Vi Dang, Fulvia Ferrazzi, Pascal Johann, Michaela Kuhlen, Constantin Lapa, Rainer Claus   +10 more
wiley   +1 more source