Results 201 to 210 of about 64,067 (262)

Methyltransferases: Functions and Applications

open access: yesChemBioChem, 2022
AbstractIn this review the current state‐of‐the‐art of S‐adenosylmethionine (SAM)‐dependent methyltransferases and SAM are evaluated. Their structural classification and diversity is introduced and key mechanistic aspects presented which are then detailed further. Then, catalytic SAM as a target for drugs, and approaches to utilise SAM as a cofactor in
Eman M M Abdelraheem   +2 more
exaly   +5 more sources

Light‐Activation of DNA‐Methyltransferases [PDF]

open access: yesAngewandte Chemie - International Edition, 2021
Abstract5‐Methylcytosine (5mC), the central epigenetic mark of mammalian DNA, plays fundamental roles in chromatin regulation. 5mC is written onto genomes by DNA methyltransferases (DNMT), and perturbation of this process is an early event in carcinogenesis.
Benjamin Buchmüller   +2 more
exaly   +7 more sources

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