Results 221 to 230 of about 64,774 (259)
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Cobalamin-Dependent Methyltransferases
Accounts of Chemical Research, 2001Cobalamin cofactors play critical roles in radical-catalyzed rearrangements and in methyl transfers. This Account focuses on the role of methylcobalamin and its structural homologues, the methylcorrinoids, as intermediaries in methyl transfer reactions, and particularly on the reaction catalyzed by cobalamin-dependent methionine synthase.
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Elongation factor methyltransferase 3 – A novel eukaryotic lysine methyltransferase
Biochemical and Biophysical Research Communications, 2014Here we describe the discovery of Saccharomycescerevisiae protein YJR129Cp as a new eukaryotic seven-beta-strand lysine methyltransferase. An immunoblotting screen of 21 putative methyltransferases showed a loss in the methylation of elongation factor 2 (EF2) on knockout of YJR129C.
Lelin, Zhang +4 more
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Lysine Methyltransferases and Their Inhibitors
2019Since 2000, the histone methyltransferases that catalyze the methylation of a number of histone and nonhistone substrates have been discovered.
Stazi, Giulia +2 more
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DNA modification by methyltransferases
Current Opinion in Structural Biology, 1995Enzymatic methylation of DNA plays important roles in both prokaryotes and eukaryotes. Structural study of the HhaI DNA methyltransferase has provided considerable insight into the chemistry of C5-cytosine methylation. The DNA-protein complex reveals a substrate cytosine flipped out of the double helix during the reaction, and a novel two-loop DNA ...
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The Actin Histidine methyltransferase SETD3 is a CHD1 lysine di-methyltransferase
Cancer LettersProtein methylation is a widespread posttranslational modification that primarily targets lysine, arginine, and histidine residues. Aberrant protein methylation has been implicated in tumorigenesis, although the specific role of SETD3, a histidine methyltransferase, in cancer remains poorly understood.
Weilin Peng +12 more
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REGULATION OF PHENYLETHANOLAMINE N-METHYLTRANSFERASE
Biochemical Pharmacology, 1973Publisher Summary This chapter discusses regulation of phenylethanolamine N-methyltransferase (PNMT). PNMT is localized almost exclusively to the adrenal medulla, although traces of activity have been reported in heart, brain, in extra-adrenal chromaffin tissue and in sympathetic ganglia.
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Methyltransferase pharmacogenetics
Journal of Basic and Clinical Physiology and Pharmacology, 1989openaire +2 more sources
DNA Methyltransferases: From Evolution to Clinical Applications
International Journal of Molecular Sciences, 2022JOSÉ Díaz-Chávez +2 more
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