Engineering Bisubstrates to Target m6Am RNA Methyltransferases: Synthesis and Computational Studies
Chemistry – A European Journal, EarlyView.Use of the convertible nucleoside approach to synthesize m6Am RNA methyltransferase bisubstrates. This methodology allows for the introduction of modifications on the SAM analog moiety and the RNA substrate part, including the introduction of a cap analog by click chemistry.
Yoann Colas +3 more
wiley +1 more source
Metabolic Control of Epigenetics and Its Role in CD8+ T Cell Differentiation and Function [PDF]
, 2019 Glauben, Rainer +3 more
core +1 more source
DNA methyltransferases and epigenetic regulation in bacteria.
FEMS Microbiology Reviews, 2016 Satish Adhikari, Patrick D. Curtis
semanticscholar +1 more source
(-)-Epicatechin Promotes Epigenetic and Metabolic Changes in an Obesity Model. [PDF]
BiomoleculesPérez-Durán J +6 more
europepmc +1 more source
CYP2C19 Genotype is Associated with Citalopram Treatment Outcomes in a Real‐World Setting
Clinical Pharmacology &Therapeutics, EarlyView.CYP2C19 metabolizes various selective serotonin reuptake inhibitors (SSRIs) and genetic CYP2C19 variants are associated with SSRI tolerability and response. Yet, whether CYP2C19 variability also impacts citalopram response remained unclear. We here evaluated associations between CYP2C19 genotypes and citalopram prescription data of 11,079 patients from
Yoomi Park +2 more
wiley +1 more source
Biochemistry and regulation of the protein arginine methyltransferases (PRMTs).
Archives of Biochemistry and Biophysics, 2016 Y. Morales +3 more
semanticscholar +1 more source
Mechanistic Insights into SAM-Dependent Methyltransferases: A Review of Computational Approaches. [PDF]
Int J Mol SciJędrzejewski M +2 more
europepmc +1 more source
Bridging maternal effects and epitranscriptomics: A novel perspective in developmental biology
Developmental Dynamics, EarlyView.Abstract Maternal effects, encompassing both genetic (maternally expressed gene products) and non‐genetic (maternal state) influences, are powerful determinants of offspring phenotype, yet their RNA‐level mechanisms remain incompletely resolved. In parallel, epitranscriptomics, an emerging field centered on chemical modifications to RNA, has revealed ...
Ehsan Pashay Ahi
wiley +1 more source
Hijacked in cancer: the KMT2 (MLL) family of methyltransferases
Nature Reviews. Cancer, 2015 R. Rao, Y. Dou
semanticscholar +1 more source
Epigenetic crosstalk between uric acid and vascular health: a role for extracellular vesicles. [PDF]
Clin EpigeneticsSchiano C, Napoli C.
europepmc +1 more source