Results 91 to 100 of about 6,012,683 (290)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

FEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka, Yuxi Liu, Stefano Maggi, Debnath Ghosal, Jue Wang, Prashant P. Damke, Stephen D. Carter, Wei Zhao, Sukhithasri Vijayrajratnam, Joseph P. Vogel, Carrie L. Shaffer, Grant J. Jensen   +11 more
wiley   +1 more source

Some Extensions of Fixed Point Results over Quasi-JS-Spaces

Journal of Function Spaces, 2016
We introduce the notion of quasi-JS-metric space. After defining the basic topological properties of quasi-JS-metric space, we investigate fixed point of certain mapping in the frame of complete quasi-JS-metric space.
Maha Noorwali, Hamed H. Alsulami, Erdal Karapınar   +2 more
doaj   +1 more source

METRIC PROJECTIONS IN LINEAR METRIC SPACES

Demonstratio Mathematica, 1990
Summary: Various properties of the metric projection are known in normed linear spaces. \textit{G. Pantelidis} [Math. Ann. 184, 30--48 (1969; Zbl 0175.42001)] discussed some of these properties in linear metric spaces. In this paper we also discuss some necessary and sufficient conditions for the metric projections to be continuous and Lipschitzian in ...
openaire   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Topographic Gromov-Hausdorff quantum Hypertopology for Quantum Proper Metric Spaces

, 2014
We construct a topology on the class of pointed proper quantum metric spaces which generalizes the topology of the Gromov-Hausdorff distance on proper metric spaces, and the topology of the dual propinquity on Leibniz quantum compact metric spaces.
Latremoliere, Frederic
core  

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Fixed Point Theorems in Complex Valued B-Metric Spaces

Cauchy: Jurnal Matematika Murni dan Aplikasi, 2017
A complex-valued b-metric space is a generalization of a b-metric space in which its b-metric space has complex value. It can also be considered as a generalization of a complex-valued metric space. Hence, fixed point theorems that have been studied in b-
Dahliatul Hasanah
doaj   +1 more source

An Inequality in Metric Spaces [PDF]

, 2004
In this note we establish a general inequality valid in metric spaces that is related to the polygonal inequality and admits also a natural geometrical interpretation.
Dragomir, Sever S, Goşa, Anca C
core  

On partial metric spaces and partial cone metric spaces

Hacettepe Journal of Mathematics and Statistics, 2017
It this article we shall show that partial metric spaces and partial cone metric spaces are quasi-uniformizable and hence quasi-metrizable. Finally, an application to the Banach’s fixed point theorem will be presented in this context.
openaire   +3 more sources