Results 51 to 60 of about 12,260 (143)

Occurrence of the enzymes effecting the conversion of acetyl CoA to squalene in homogenates of hog aorta

Journal of Lipid Research, 1973
Homogenates and subcellular fractions of the intima–media of hog aorta have been prepared and examined for the presence of the enzymes catalyzing the conversion of acetyl CoA to squalene.
Linda L. Slakey, Gene C. Ness, Nilofer Qureshi, John W. Porter   +3 more
doaj   +1 more source

Discovery of a metabolic alternative to the classical mevalonate pathway

eLife, 2013
Eukarya, Archaea, and some Bacteria encode all or part of the essential mevalonate (MVA) metabolic pathway clinically modulated using statins. Curiously, two components of the MVA pathway are often absent from archaeal genomes.
Nikki Dellas, Suzanne T Thomas, Gerard Manning, Joseph P Noel   +3 more
doaj   +1 more source

Efficacy of Anakinra Treatment in two Moroccan Patients With Mevalonate Kinase Deficiency. [PDF]

Glob Pediatr Health, 2023
Souali M, Sakhi A, Bousfiha AA, Bouayed K.   +3 more
europepmc   +1 more source

Statins regulate kinase signaling by causing changes in phosphorylation, rather than through changes in gene expression or direct inhibition: evidence in colorectal cancer

Frontiers in Pharmacology
IntroductionStatins, widely used for hypercholesterolemia, have shown anticancer properties including induction of apoptosis and ferroptosis, modulation of autophagy, and reprogramming of the tumor microenvironment, making them potential candidates for ...
Francisco Alejandro Lagunas-Rangel, Francisco Alejandro Lagunas-Rangel, Jörgen Jonsson, Ludmila Jackevica, Robert Fredriksson, Maija Dambrova, Maija Dambrova, Helgi B. Schiöth, Helgi B. Schiöth   +8 more
doaj   +1 more source

Two Siblings With Recurrent Fevers: The Path to Mevalonate Kinase Deficiency Diagnosis. [PDF]

Cureus, 2023
Pereira-Nunes J, Ferreras C, Grangeia A, Aguiar F, Rodrigues M, Brito I.   +5 more
europepmc   +1 more source

Case Report: Early-onset mevalonic aciduria in neonates with inflammatory marker elevated

Frontiers in Immunology
PurposeThe aim of this study was to present a case of early-onset mevalonic aciduria (MA) in a neonate and summarize the relevant phenotypic and genotypic spectra of MA.Methods and resultsWe describe a neonate who presented with elevated inflammatory ...
Shanshan Xue, Shanshan Xue, Wujuan Shi, Wujuan Shi, Xiaobo He, Xiaobo He, Lihong Hao, Lihong Hao   +7 more
doaj   +1 more source

Mevalonate kinase gene polymorphisms in ankylosing spondylitis patients: A cross-sectional study. [PDF]

Arch Rheumatol, 2023
Yıldız F, Dinkçi S, Erken E.
europepmc   +1 more source

The efficacy and safety of allogeneic stem cell transplantation in Mevalonate Kinase Deficiency. [PDF]

Pediatr Rheumatol Online J, 2022
Jeyaratnam J, Faraci M, Gennery AR, Drabko K, Algeri M, Morimoto A, Sirait T, Lankester AC, Albert M, Neven B, Frenkel J, EBMT Inborn Errors Working Party.   +11 more
europepmc   +1 more source

Mixed porokeratosis with a novel mevalonate kinase gene mutation: A case report. [PDF]

World J Clin Cases, 2022
Xu HJ, Wen GD.
europepmc   +1 more source

Mechanistic insight into the role of mevalonate kinase by a natural fatty acid-mediated killing of Leishmania donovani. [PDF]

Sci Rep, 2022
Prasad SR, Kumar P, Mandal S, Mohan A, Chaurasia R, Shrivastava A, Nikhil P, Aishwarya D, Ramalingam P, Gajbhiye R, Singh S, Dasgupta A, Chourasia M, Ravichandiran V, Das P, Mandal D.   +15 more
europepmc   +1 more source